个人简介

Dr. Alan Richard Schwartz is a professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include pulmonary disease and critical care medicine. Dr. Schwartz directs the Johns Hopkins Sleep Disorders Center at Bayview Campus, the Sleep Medicine Fellowship Program and the Center for Interdisciplinary Sleep Research and Education with its Sleep Core Research Laboratory and Scoring Hub (Johns Hopkins Bayview Medical campus). He earned his M.D. from Johns Hopkins, completed his residency in internal medicine at Mount Sinai Medical Center and performed a fellowship in pulmonary, critical care and sleep medicine at Johns Hopkins. Dr. Schwartz’s research interests include obesity and sleep apnea pathogenesis, nocturnal hypoxemia in COPD, and obesity and neural control in sleep-disordered breathing. He has served on the American Thoracic Society Program Committee and currently serves on the Planning Committee for the Sleep and Respiratory Neurobiology Assembly. He was recognized by the Department of Medicine with a Levine Excellence in Mentoring Award in 2011.

研究领域

Obesity and sleep apnea pathogenesis; Nocturnal hypoxemia in COPD; Obesity and neural control in sleep-disordered breathing

Dr. Schwartz has investigated mechanisms of sleep disordered breathing with a special emphasis on novel approaches to the diagnosis and management of this disorder. He has a longstanding record of piloting new methods to assess the severity of upper airway obstruction during sleep and treat sleep apnea. He also has extensive experience developing clinical and animal models of sleep-disordered breathing, focusing on both underlying pathogenic mechanisms and consequences of this disorder. Dr. Schwartz is an established investigator with a long track record in NIH- and industry-sponsored research studies. He has participated actively in the development of several novel diagnostic instruments and treatments for sleep apnea, including hypoglossal nerve stimulation and high-flow transtracheal and transnasal insufflation.

近期论文

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McGinley BM, Kirkness JP, Schneider H, Lenka A, Smith PL, Schwartz AR. "Utilizing inspiratory airflows during standard polysomnography to assess pharyngeal function in children during sleep." Pediatr Pulmonol. 2015 Oct 16. doi: 10.1002/ppul.23329. [Epub ahead of print] Pho H, Hernandez AB, Arias RS, Leitner EB, Van Kooten S, Kirkness JP, Schneider H, Smith PL, Polotsky VY, Schwartz AR. "The effect of leptin replacement on sleep disordered breathing in the leptin-deficient ob/ob mouse." J Appl Physiol (1985). 2015 Oct 15:jap.00494.2015. doi: 10.1152/japplphysiol.00494.2015. [Epub ahead of print] Pham LV, Schwartz AR. "The pathogenesis of obstructive sleep apnea." J Thorac Dis. 2015 Aug;7(8):1358-72. doi: 10.3978/j.issn.2072-1439.2015.07.28. Review. Schwartz AR, Levin FL, O'Neil JA Jr, Braithwaite RS. "Pilot of decision support to individualize colorectal cancer screening recommendations." Am J Manag Care. 2015 Jul 1;21(7):e439-46. Hadac JN, Leystra AA, Paul Olson TJ, Maher ME, Payne SN, Yueh AE, Schwartz AR, Albrecht DM, Clipson L, Pasch CA, Matkowskyj KA, Halberg RB, Deming DA. "Colon tumors with the simultaneous induction of driver mutations in APC, KRAS, and PIK3CA still progress through the adenoma-to-carcinoma sequence." Cancer Prev Res (Phila). 2015 Oct;8(10):952-61. doi: 10.1158/1940-6207.CAPR-15-0003. Epub 2015 Aug 14. Brigham EP, Patil SP, Jacobson LP, Margolick JB, Godfrey R, Johnson J, Johnson-Hill LM, Reynolds S, Schwartz AR, Smith PL, Brown TT. Association between systemic inflammation and obstructive sleep apnea in men with or at risk for HIV infection. Antivir Ther. 2014 Feb 12. doi: 10.3851/IMP2745. [Epub ahead of print] PMID: 24518040 Schwartz AR, Smith PL, Oliven A. Electrical stimulation of the hypoglossal nerve: a potential therapy. J Appl Physiol (1985). 2014 Feb;116(3):337-44. doi: 10.1152/japplphysiol.00423.2013. Epub 2013 Jun 27. PMID: 23813525 [PubMed - in process] Kezirian EJ, Goding GS Jr, Malhotra A, O'Donoghue FJ, Zammit G, Wheatley JR, Catcheside PG, Smith PL, Schwartz AR, Walsh JH, Maddison KJ, Claman DM, Huntley T, Park SY, Campbell MC, Palme CE, Iber C, Eastwood PR, Hillman DR, Barnes M. Hypoglossal nerve stimulation improves obstructive sleep apnea: 12-month outcomes. J Sleep Res. 2014 Feb;23(1):77-83. doi: 10.1111/jsr.12079. Epub 2013 Sep 4. PMID: 24033656 [PubMed - in process] Esquinas AM, Papadakos PJ, Schwartz AR. Sleep patterns during long-term mechanical ventilation in tracheostomized patients in the ICU: do they matter? Crit Care Med. 2014 Jan;42(1):e82-3. doi: 10.1097/CCM.0b013e3182a84ccd. No abstract available. PMID: 24346550 Hillman DR, Walsh JH, Maddison KJ, Platt PR, Schwartz AR, Eastwood PR. The effect of diaphragm contraction on upper airway collapsibility. J Appl Physiol (1985). 2013 Aug 1;115(3):337-45. doi: 10.1152/japplphysiol.01199.2012. Epub 2013 May 2. PMID: 23640590 Drager LF, Yao Q, Hernandez KL, Shin MK, Bevans-Fonti S, Gay J, Sussan TE, Jun JC, Myers AC, Olivecrona G, Schwartz AR, Halberg N, Scherer PE, Semenza GL, Powell DR, Polotsky VY. Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4. Am J Respir Crit Care Med. 2013 Jul 15;188(2):240-8. doi: 10.1164/rccm.201209-1688OC. PMID: 23328524 Wei T, Erlacher MA, Grossman P, Leitner EB, McGinley BM, Patil SP, Smith PL, Schneider H, Schwartz AR, Kirkness JP. Approach for streamlining measurement of complex physiological phenotypes of upper airway collapsibility. Comput Biol Med. 2013 Jun;43(5):600-6. doi: 10.1016/j.compbiomed.2012.12.006. Epub 2013 Mar 18. PMID: 23517555 Schwartz AR, Smith PL. Rebuttal from Alan R. Schwartz and Philip L. Smith. J Physiol. 2013 May 1;591(Pt 9):2235. doi: 10.1113/jphysiol.2013.252528. No abstract available. PMID: 23740881 Schwartz AR, Smith PL. CrossTalk proposal: the human upper airway does behave like a Starling resistor during sleep. J Physiol. 2013 May 1;591(Pt 9):2229-32. doi: 10.1113/jphysiol.2012.250654. No abstract available. PMID: 23740879 Dotan Y, Pillar G, Tov N, Oliven R, Steinfeld U, Gaitini L, Odeh M, Schwartz AR, Oliven A. Dissociation of electromyogram and mechanical response in sleep apnoea during propofol anaesthesia. Eur Respir J. 2013 Jan;41(1):74-84. doi: 10.1183/09031936.00159611. Epub 2012 May 3. PMID: 22556023 Rodríguez AM, Conde B, Schwartz AR. Monitoring noninvasive ventilation of home bilevel ventilators: are bench studies more necessary and familiar? Chest. 2012 Dec;142(6):1692-3; author reply 1693-4. doi: 10.1378/chest.12-1664. No abstract available. PMID: 23208356