个人简介

Dr. Paul B. Rothman is a professor of medicine at the Johns Hopkins University School of Medicine. He holds a secondary appointment in the Department of Molecular Biology and Genetics. A rheumatologist and molecular immunologist, Dr. Rothman serves as the Frances Watt Baker, M.D., and Lenox D. Baker Jr., M.D., Dean of the Medical Faculty. He is also vice president for medicine at Johns Hopkins University and chief executive officer of Johns Hopkins Medicine. Dr. Rothman earned his medical degree (Alpha Omega Alpha) at Yale University School of Medicine. He completed both an internal medicine residency and a rheumatology fellowship at New York Presbyterian Hospital, as well as a postdoctoral biochemistry fellowship at Columbia University College of Physicians and Surgeons. He also holds a Bachelor of Science in biology (Phi Beta Kappa) from the Massachusetts Institute of Technology. Dr. Rothman’s research focuses on the role of cytokines in the development of blood cells called leukocytes—the abnormal development of which can lead to leukemia—and in immune responses to asthma and allergies. Before joining the Johns Hopkins faculty in 2011, Dr. Rothman served as dean of the University of Iowa Carver College of Medicine and leader of the university’s clinical practice plan. Prior to that, he served as professor and head of Iowa’s Department of Internal Medicine, with secondary appointments in the Department of Microbiology and the Department of Physiology and Biophysics. On the faculty of the Columbia University College of Physicians and Surgeons from 1986 to 2004, Dr. Rothman was the founding chief of its Division of Pulmonary, Allergy and Critical Care Medicine. He later served as vice chair for research of the Department of Medicine. Dr. Rothman’s awards include a James S. McDonnell Foundation Career Development Award, a Pfizer Scholars Award, a Pew Scholars Award, a Leukemia Society of America Scholar Award and the Pharmacia Allergy Research Foundation International Award. He is an elected member of the American Association for the Advancement of Science, American College of Physicians, Council of the Association of American Physicians and American Society of Clinical Investigation. Dr. Rothman is a member of the Merck Board of Directors and receives compensation in the form of income and stock. Dr. Rothman has served as a member of the National Institutes of Health Immunologic Sciences Study Section, the Israel Cancer Research Fund International Scientific Advisory Board, the American Academy of Allergy, Asthma and Immunology Grant Review Committee and the American Thoracic Society Asthma Immunology and Inflammation Program Committee.

研究领域

Cytokines; Leukocytes; Immune responses to asthma and allergies

Dr. Rothman’s research on cytokines (immune system molecules) focuses on their role in the development of blood cells called leukocytes. Abnormal development of these blood cells can lead to leukemia. He also studies the role of cytokines in immune system responses to asthma and allergies.

近期论文

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Rothman PB. "Medicine in 2055." J Clin Invest. 2015 Sep 1;125(9):3316-20. doi: 10.1172/JCI83516. Epub 2015 Aug 4. No abstract available. Levine AS, Alpern RJ, Andrews NC, Antman K, Balser JR, Berg JM, Davis PB, Fitz JG, Golden RN, Goldman L, Jameson JL, Lee VS, Polonsky KS, Rappley MD, Reece EA, Rothman PB, Schwinn DA, Shapiro LJ, Spiegel AM. "Research in academic medical centers: two threats to sustainable support." Sci Transl Med. 2015 May 27;7(289):289fs22. doi: 10.1126/scitranslmed.aac5200. Li Y, Chen HL, Bannick N, Henry M, Holm AN, Metwali A, Urban JF Jr, Rothman PB, Weiner GJ, Blazar BR, Elliott DE, Ince MN. "Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice." J Immunol. 2015 Feb 1;194(3):1011-20. doi: 10.4049/jimmunol.1303099. Epub 2014 Dec 19. Pronovost PJ, Armstrong CM, Demski R, Callender T, Winner L, Miller MR, Austin JM, Berenholtz SM, Yang T, Peterson RR, Reitz JA, Bennett RG, Broccolino VA, Davis RO, Gragnolati BA, Green GE, Rothman PB. "Creating a high-reliability health care system: improving performance on core processes of care at Johns Hopkins Medicine." Acad Med. 2015 Feb;90(2):165-72. doi: 10.1097/ACM.0000000000000610. Sojka DK, Plougastel-Douglas B, Yang L, Pak-Wittel MA, Artyomov MN, Ivanova Y, Zhong C, Chase JM, Rothman PB, Yu J, Riley JK, Zhu J, Tian Z, Yokoyama WM. "Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells." Elife. 2014 Jan 1;3:e01659. doi: 10.7554/eLife.01659. Gorman JV, Starbeck-Miller G, Pham NL, Traver GL, Rothman PB, Harty JT, Colgan JD. "Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection." J Immunol. 2014 Apr 1;192(7):3133-42. doi: 10.4049/jimmunol.1302290. Epub 2014 Feb 24. Kobayashi T, Steinbach EC, Russo SM, Matsuoka K, Nochi T, Maharshak N, Borst LB, Hostager B, Garcia-Martinez JV, Rothman PB, Kashiwada M, Sheikh SZ, Murray PJ, Plevy SE. "NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis." J Immunol. 2014 Feb 15;192(4):1918-27. doi: 10.4049/jimmunol.1301819. Epub 2014 Jan 17. Firth MA, Madera S, Beaulieu AM, Gasteiger G, Castillo EF, Schluns KS, Kubo M, Rothman PB, Vivier E, Sun JC. "Nfil3-independent lineage maintenance and antiviral response of natural killer cells." J Exp Med. 2013 Dec 16;210(13):2981-90. doi: 10.1084/jem.20130417. Epub 2013 Nov 25. Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV. "TH17 cell differentiation is regulated by the circadian clock." Science. 2013 Nov 8;342(6159):727-30. doi: 10.1126/science.1243884. Capuano MM, Sorkin JD, Chang YP, Ling H, O'Connell JR, Rothman PB, Mitchell BD, Silver KD. "Polymorphisms in the SOCS7 gene and glucose homeostasis traits." BMC Res Notes. 2013 Jun 15;6:235. doi: 10.1186/1756-0500-6-235.