个人简介

Dr. Naresh M. Punjabi is a professor of medicine at the Johns Hopkins University School of Medicine. He holds a joint appointment in epidemiology at the Johns Hopkins Bloomberg School of Public Health. His areas of clinical expertise include sleep disorders and sleep medicine. Dr. Punjabi earned his M.D. from the University of Chicago Pritzker School of Medicine. He completed his residency and performed a fellowship in pulmonary and critical care medicine at Johns Hopkins. His research interests include sleep apnea-related cardiovascular and metabolic outcomes; effects of sleep apnea on cardiovascular and metabolic outcomes; and epidemiology of sleep apnea. Dr. Punjabi serves on the Multidisciplinary Advisory Committee (MAC) for the Johns Hopkins Clinical Research Scholars Program. He is a member of the American Academy of Sleep Medicine, the American College of Chest Physicians and the American Thoracic Society.

研究领域

Sleep apnea-related cardiovascular and metabolic outcomes; Effects of sleep apnea on cardiovascular and metabolic

Dr. Punjabi’s current research focuses on the epidemiology of sleep apnea with a particular emphasis on associated sequelae, including insulin resistance, type 2 diabetes mellitus and cardiovascular disease. He has been one of the principal investigators for the multi-center Sleep Heart Health Study, an epidemiological study on the longitudinal effects of sleep apnea on hypertension, cardiovascular disease and mortality. His clinical research laboratory is examining the independent effects of intermittent hypoxia on various pathways to help elucidate the links between sleep apnea, insulin resistance and metabolic dysfunction.

近期论文

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Cade BE, Gottlieb DJ, Lauderdale DS, Bennett DA, Buchman AS, Buxbaum SG, De Jager PL, Evans DS, Fülöp T, Gharib SA, Johnson WC, Kim H, Larkin EK, Lee SK, Lim AS, Punjabi NM, Shin C, Stone KL, Tranah GJ, Weng J, Yaffe K, Zee PC, Patel SR, Zhu X, Redline S, Saxena R. "Common variants in DRD2 are associated with sleep duration: The CARe Consortium." Hum Mol Genet. 2015 Oct 13. pii: ddv434. Lutsey PL, Bengtson LG, Punjabi NM, Shahar E, Mosley TH, Gottesman RF, Wruck LM, MacLehose RF, Alonso A. "Obstructive sleep apnea and 15-year cognitive decline: the atherosclerosis risk in communities (ARIC) study." Sleep. 2015 Oct 5. pii: sp-00219-15. [Epub ahead of print] Chami HA, Gottlieb DJ, Redline S, Punjabi NM. "Association between glucose metabolism and sleep-disordered breathing during REM sleep." Am J Respir Crit Care Med. 2015 Nov 1;192(9):1118-26. doi: 10.1164/rccm.201501-0046OC. Kudchadkar SR, Yaster M, Punjabi AN, Quan SF, Goodwin JL, Easley RB, Punjabi NM. "Temporal characteristics of the sleep EEG power spectrum in critically ill children." J Clin Sleep Med. 2015 Jul 13. pii: jc-00131-15. [Epub ahead of print] Punjabi NM. "Rebuttal from Dr. Punjabi." Chest. 2015 Jul 16. doi: 10.1378/chest.15-1321. [Epub ahead of print] Seif F, Patel SR, Walia HK, Rueschman M, Bhatt DL, Blumenthal RS, Quan SF, Gottlieb DJ, Lewis EF, Patil SP, Punjabi NM, Babineau DC, Redline S, Mehra R. Obstructive sleep apnea and diurnal nondipping hemodynamic indices in patients at increased cardiovascular risk. J Hypertens. 2013 Dec 16. [Epub ahead of print] PMID: 24351803Tare A, Lane JM, Cade BE, Grant SF, Chen TH, Punjabi NM, Lauderdale DS, Zee PC, Gharib SA, Gottlieb DJ, Scheer FA, Redline S, Saxena R. Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes. Diabetologia. 2013 Nov 27. [Epub ahead of print] PMID: 24280871 Rao MN, Blackwell T, Redline S, Punjabi NM, Barrett-Connor E, Neylan TC, Stone KL; Association between sleep duration and 24-hour urine free cortisol in the MrOS Sleep Study. Osteoporotic Fractures in Men (MrOS) Study Group. PLoS One. 2013 Sep 27;8(9):e75205. doi: 10.1371/journal.pone.0075205. PMID: 24228086 [PubMed - in process] Polak J, Shimoda LA, Drager LF, Undem C, McHugh H, Polotsky VY, Punjabi NM. Intermittent hypoxia impairs glucose homeostasis in C57BL6/J mice: partial improvement with cessation of the exposure. Sleep. 2013 Oct 1;36(10):1483-90; 1490A-1490B. doi: 10.5665/sleep.3040. PMID: 24082307 [PubMed - in process] Lane JM, Tare A, Cade BE, Chen TH, Punjabi NM, Gottlieb DJ, Scheer FA, Redline S, Saxena R. Common Variants in CLOCK Are Not Associated with Measures of Sleep Duration in People of European Ancestry from the Sleep Heart Health Study. Biol Psychiatry. 2013 Dec 15;74(12):e33-5. doi: 10.1016/j.biopsych.2013.06.006. Epub 2013 Jul 17. No abstract available. PMID: 23871470 [PubMed - in process] Kudchadkar SR, Aljohani OA, Punjabi NM. Sleep of critically ill children in the pediatric intensive care unit: A systematic review. Sleep Med Rev. 2013 May 21. pii: S1087-0792(13)00025-7. doi: 10.1016/j.smrv.2013.02.002. [Epub ahead of print] PMID: 23702219 Powell R, Davidson D, Divers J, Manichaikul A, Carr JJ, Detrano R, Hoffman EA, Jiang R, Kronmal RA, Liu K, Punjabi NM, Shahar E, Watson KE, Rotter JI, Taylor KD, Rich SS, Barr RG. Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: a cross-sectional study. Thorax. 2013 Jul;68(7):634-42. doi: 10.1136/thoraxjnl-2012-202116. Epub 2013 Apr 12. PMID: 23585509 Ramanathan R, Kohli A, Ingaramo MC, Jain A, Leng SX, Punjabi NM, Walston JD, Fedarko NS. Serum chitotriosidase, a putative marker of chronically activated macrophages, increases with normal aging. J Gerontol A Biol Sci Med Sci. 2013 Oct;68(10):1303-9. doi: 10.1093/gerona/glt022. Epub 2013 Mar 22. PMID: 23525479 Punjabi NM, Aurora RN, Patil SP. Home sleep testing for obstructive sleep apnea: one night is enough! Chest. 2013 Feb 1;143(2):291-4. doi: 10.1378/chest.12-2699. No abstract available. PMID: 23381307 Langrock R, Swihart BJ, Caffo BS, Punjabi NM, Crainiceanu CM. Combining hidden Markov models for comparing the dynamics of multiple sleep electroencephalograms. Stat Med. 2013 Aug 30;32(19):3342-56. doi: 10.1002/sim.5747. Epub 2013 Jan 24. PMID: 23348835