Polotsky, Vsevolod - Johns Hopkins University

个人简介

Dr. Vsevolod Y. (Seva) Polotsky is a professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include critical care medicine and pulmonary medicine. Dr. Polotsky earned his M.D. from Pavlov State Medical University. He completed residencies at Pavlov State Medical University and Norwalk Hospital. He performed a fellowship at the Weizmann Institute Weinberg Graduate School and a fellowship in medicine at Johns Hopkins. His research interests include hypoxia, obesity and metabolic syndrome. Dr. Polotsky is a member of several professional organizations, including the American Academy of Sleep Medicine and the American Thoracic Society.

研究领域

Hypoxia; Obesity; Metabolic Syndrome; Obstructive Sleep Apnea

近期论文

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Polak J, Shimoda LA, Drager LF, Undem C, McHugh H, Polotsky VY, Punjabi NM. Intermittent hypoxia impairs glucose metabolism in C57BL6/J mice: partial improvement with cessation of the exposure. Sleep. 2013 Oct 1;36(10):1483-1490. Drager LF, Yao Q, Hernandez KL, Shin M-K; Bevans-Fonti S, Gay J, Sussan TE, Jun JC, Myers AC, Olivecrona G, Schwartz AR, Halberg N, Scherer PE, Semenza GL, Powell DR, Polotsky VY. Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4. Am J Respir Crit Care Med. 2013 Jul 15;188(2):240-8. Aggarwal NR, D'Alessio FR, Eto Y, Chau E, Avalos C, Waickman AT, Garibaldi BT, Mock JR, Files DC, Sidhaye V, Polotsky VY, Powell J, Horton M, and King LS. Macrophage A2A adenosinergic receptor (ADORA2A) modulates oxygen-induced augmentation of murine lung injury. Am J Respir Cell Mol Biol. 2013 May;48(5):635-46. Yao Q, Shin M-K, Jun JC, Hernandez KL, Aggarwal NR, Mock JR, Gay J, Drager LF, Polotsky VY. The effect of chronic intermittent hypoxia on triglyceride uptake in different tissues. J Lipid Res. 2013 Apr;54(4):1058-65. Jun JC, Shin MK, Yao Q, Devera R, Bevans-Fonti S, and Polotsky VY. Thermoneutrality Modifies the Impact of Hypoxia on Lipid Metabolism. Am J Physiol Endocrinol Metab. 2013 Feb;304(4):E424-35. Shin M-K, Drager LF, Yao Q, Bevans-Fonti S, Yoo D-Y, Jun JC, Aja S, Bhanot S, and Polotsky VY. Metabolic consequences of high fat diet are attenuated by suppression of HIF-1a. PLoS One. 2012 Oct 1;7(10): e46562. Jun JC, Shin MK, Yao Q, Bevans-Fonti S, Poole J, Drager LF, and Polotsky VY. Acute hypoxia induces hypertriglyceridemia by decreasing plasma triglyceride clearance in mice. Am J Physiol Endocrinol Metab. 2012 Aug;303(3):E377-88. Polotsky M., El-Sayed A., Pichard LE, Harris CC, Smith PL, Schneider H., Kirkness JP, Polotsky VY, Schwartz AR. Effects of leptin and obesity on the upper airway. J Appl Physiol. 2012 May;112(10):1637-43. Reinke C, Bevans-Fonti S, Drager LF, Shin M-K and Polotsky VY. Effects of different hypoxic regimens on tissue oxygen profiles and metabolic outcomes. J Appl Physiol. 2011 Sep;111(3):881-90. Polotsky M., El-Sayed A., Smith PL, Schneider H., Kirkness JP, Polotsky VY, Schwartz AR. Effect of age and weight on upper airway function in a mouse model. J Appl Physiol. 2011 Sep;111(3):696-703. Drager LF, Li J, Reinke C, Bevans-Fonti S, Jun JC and Polotsky VY. Intermittent hypoxia exacerbates metabolic effects of diet-induced obesity. Obesity (Silver Spring). 2011 Nov; 19(11):2167-2174. Drager LF, Li J, Shin M-K, Reinke C, Aggarwal NR, Jun JC, Bevans-Fonti S, Cztalryd C, O'Byrne SM, Kroupa O, Olivecrona G, Blaner WS and Polotsky VY. Intermittent Hypoxia Inhibits Clearance of Triglyceride Rich Lipoproteins and Inactivates Adipose Lipoprotein Lipase in a Mouse Model of Sleep Apnea. Eur Heart J. 2012 Mar;33(6):783-90. Epub 2011 Apr 9. Jun JC, Drager LF, Najjar SS, Gottlieb SS, Brown CD, Smith PL, Schwartz AR, Polotsky VY. Effects of sleep apnea on nocturnal free fatty acids in subjects with heart failure. SLEEP 2011;34(9):1207-1213. Pallayova M, Steele KE, Magnuson TH, Schweitzer MA, Smith PL, Patil SP, Bevans-Fonti S, Polotsky VY, Schwartz AR. Sleep Apnea Determines Soluble TNF-a Receptor 2 Response to Massive Weight Loss. Obes Surg. 2011 Sep;21(9):1413-23. Yang R, Sikka G, Larson J, Watts VL, Niu X, Ellis C, Miller K, Camara A, Reinke C, Savransky V, Polotsky VY, O'Donnell CP, Berkowitz DE, and Barouch LA. Restoring Leptin Signaling Reduces Hyperlipidemia and Improves Vascular Stiffness Induced by Chronic Intermittent Hypoxia. Am. J. Physiol. Heart Circ. Physiol. 2011 Apr;300 (4): H1467-76. Reinke C, Bevans-Fonti S, Grigoryev DN, Drager LF, Myers AC, Wise RA, Schwartz AR, Mitzner W and Polotsky VY. Chronic Intermittent Hypoxia Induces Lung Growth in Adult Mice Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L266-73. Drager LF, Heno FL, Maki-Nunes, C, Trombetta, IC, Toschi-Dias, E, Alves, MJ, Fraga RF, Jun JJ, Negrão, CE, Krieger EM, Polotsky VY and Lorenzi-Filho, G. The Impact of Obstructive Sleep Apnea on Metabolic and Inflammatory Markers in Consecutive Patients with Metabolic Syndrome. PLoS One. 2010 Aug 11;5(8). pii: e12065. Polotsky VY, Savransky V, Bevans-Fonti S, Reinke C, Li J, Grigoryev DN, Shimoda LA. Intermittent and sustained hypoxia induce a similar gene expression profile in the human aortic endothelial cells. Physiol Genomics, May 1, 2010; 41(3): 306 - 314. Aggarwal NR, D'Alessio FR, Tsushima K, Files DC, Damarla M, Sidhaye VK, Fraig MM, Polotsky VY, King LS. Moderate oxygen augments lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2010 Mar;298(3):L371-81. Epub 2009 Dec 24. Jun J, Reinke C, Bedja D, Berkowitz D, Bevans-Fonti S, Li J, Barouch LA, Gabrielson K, and Polotsky VY. Effect of Intermittent Hypoxia on Atherosclerosis in Apolipoprotein E-deficient Mice. Atherosclerosis. 2010 Apr;209(2):381-386. Epub 2009 Oct 17. Savransky V, Reinke C, Jun J, Bevans-Fonti S, Nanayakkara A, Li J, Myers AC, Torbenson MS, and Polotsky VY. Chronic Intermittent Hypoxia and Acetaminophen Induce Synergistic Liver Injury. Exp Physiol. 2009; 94:228-39. Polotsky VY, Patil SP, Savransky V, Laffan A, Fonti S, Frame LA, Steele KE, Schweitzer MA, Clark JM, Torbenson MS, Schwartz AR. Obstructive Sleep Apnea, Insulin resistance and Steatohepatitis in Severe Obesity. Am. J. Respir. Crit. Care Med. 2009; 179: 228-234. Sussan TE, Jun J, Thimmulappa R, Bedja D, Antero M, Gabrielson KL, Polotsky VY, Biswal S. Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice. PLoS ONE. 2008;3(11):e3791. Epub 2008 Nov 21. Savransky V., Jun J., Li J., Nanayakkara A, Fonti S., Moser AB, Steele KE, Schweitzer MA, Patil SP, Bhanot S., Schwartz AR, and Polotsky VY. Dyslipidemia and Atherosclerosis Induced by Chronic Intermittent Hypoxia Are Attenuated by Deficiency of Stearoyl Coenzyme A Desaturase. Circ. Res. 2008 Nov 7;103(10):1173-80. Balbir A, Lande B, Fitzgerald RS, Polotsky V, Mitzner W, Shirahata M. Behavioral and respiratory characteristics during sleep in neonatal DBA/2J and A/J mice. Brain Res. 2008 Nov 19;1241:84-91.