Pearse, David - Johns Hopkins University

个人简介

Dr. David Bennett Pearse is a professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include pulmonary disease and critical care medicine. Dr. Pearse serves as the medical director of Johns Hopkins Bayview Hospital Medical Intensive Care Unit (MICU). Dr. Pearse earned his M.D. from the University of Florida College of Medicine. He completed his residency at Johns Hopkins. He performed a fellowship in pulmonary medicine and a fellowship in critical care medicine at Johns Hopkins. His research interests include pulmonary endothelial barrier function, acute lung injury and pulmonary thromboembolism.

研究领域

Pulmonary endothelial barrier function; Acute lung injury; Pulmonary thromboembolism

近期论文

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Suresh K, Servinsky LE, Reyes J, Baksh S, Undem C, Caterina MJ, Pearse DB, Shimoda LA. "Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4." Am J Physiol Lung Cell Mol Physiol. 2015 Oct 9:ajplung.00275.2015. doi: 10.1152/ajplung.00275.2015. [Epub ahead of print] Terry PB, Pearse DB. "When right is redundant." Chest. 2015 Jun;147(6):e238. doi: 10.1378/chest.15-0204. No abstract available. Hikmat F, Pearse DB, Damarla M. "A presentation of massive hemoptysis in a patient with Churg-Strauss syndrome." Can Respir J. 2014 November/December;21(6):337-340. Epub 2014 Sep 25. Rentsendorj O, D'Alessio FR, Pearse DB. "Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages." J Leukoc Biol. 2014 Nov;96(5):907-15. doi: 10.1189/jlb.3A0314-152R. Epub 2014 Jul 25. Stephens RS, Servinsky LE, Rentsendorj O, Kolb TM, Pfeifer A, Pearse DB. "Protein kinase G increases antioxidant function in lung microvascular endothelial cells by inhibiting the c-Abl tyrosine kinase." Am J Physiol Cell Physiol. 2014 Mar 15;306(6):C559-69. doi: 10.1152/ajpcell.00375.2012. Epub 2014 Jan 8. Stephens RS, Servinsky LE, Rentsendorj O, Kolb TM, Pfeifer A, and Pearse DB. Protein kinase G increases antioxidant function in lung microvascular endothelial cells by inhibiting the c-Abl tyrosine kinase. Am J Physiol Cell Physiol. 2014; 306(6); C559-C569. PMID: 24401847 [PubMed - in process] Kolb TM, King LS, Pearse DB. A 32-year-old woman with dyspnea, lung cysts, and previous pneumothoraces. Chest. 2013 Dec 1;144(6):1964-8. doi: 10.1378/chest.13-0902. PMID: 24297131 [PubMed - in process] Anidi IU, Servinsky LE, Rentsendorj O, Stephens RS, Scott AL, Pearse DB. CD36 and Fyn kinase mediate malaria-induced lung endothelial barrier dysfunction in mice infected with Plasmodium berghei. PLoS One. 2013 Aug 15;8(8):e71010. doi: 10.1371/journal.pone.0071010. eCollection 2013. PMID: 23967147 [PubMed - in process] D'Alessio FR, Tsushima K, Aggarwal NR, Mock JR, Eto Y, Garibaldi BT, Files DC, Avalos CR, Rodriguez JV, Waickman AT, Reddy SP, Pearse DB, Sidhaye VK, Hassoun PM, Crow MT, King LS. Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase. J Immunol. 2012 Sep 1;189(5):2234-45. doi: 10.4049/jimmunol.1102606. Epub 2012 Jul 27. PMID: 22844117 Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM. The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med. 2012 Aug;18(8):1217-23. doi: 10.1038/nm.2843. Epub 2012 Jul 22. PMID: 22820644 Eberlein M, Reed RM, Permutt S, Chahla MF, Bolukbas S, Nathan SD, Iacono A, Pearse DB, Fessler HE, Shah AS, Orens JB, Brower RG. Parameters of donor-recipient size mismatch and survival after bilateral lung transplantation. J Heart Lung Transplant. 2012 Nov;31(11):1207-1213.e7. doi: 10.1016/j.healun.2011.07.015. Epub 2011 Oct 28. PMID: 22036314 Eberlein M, Permutt S, Chahla MF, Bolukbas S, Nathan SD, Shlobin OA, Shelhamer JH, Reed RM, Pearse DB, Orens JB, Brower RG. Lung size mismatch in bilateral lung transplantation is associated with allograft function and bronchiolitis obliterans syndrome. Chest. 2012 Feb;141(2):451-60. doi: 10.1378/chest.11-0767. Epub 2011 Jul 28. PMID: 21799025 Rentsendorj O, Damarla M, Aggarwal NR, Choi JY, Johnston L, D'Alessio FR, Crow MT, Pearse DB. Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2011 Aug;301(2):L161-70. doi: 10.1152/ajplung.00073.2011. Epub 2011 May 13. PMID: 21571906 Eberlein M, Permutt S, Brown RH, Brooker A, Chahla MF, Bolukbas S, Nathan SD, Pearse DB, Orens JB, Brower RG. Supranormal expiratory airflow after bilateral lung transplantation is associated with improved survival. Am J Respir Crit Care Med. 2011 Jan 1;183(1):79-87. doi: 10.1164/rccm.201004-0593OC. Epub 2010 Aug 6. PMID: 20693376