Oh, Esther - Johns Hopkins University - Department of Medicine

个人简介

Dr. Esther Oh is an associate professor of medicine, pathology, and psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include geriatric medicine, geriatric psychiatry, and mood disorders. Dr. Oh also serves as the associate director of the Johns Hopkins Memory and Alzheimer’s Treatment Center. Dr. Oh earned her M.D. from Chicago Medical School/University of Health Science. She completed her residency in internal medicine at the University of Illinois at Chicago and performed a fellowship in geriatric medicine and gerontology at Johns Hopkins University School of Medicine. Her research interest is the development of biomarkers for different stages of dementia, as markers of early detection as well as for markers of treatment response. Dr. Oh is certified in geriatrics and internal medicine by the American Board of Internal Medicine. She is a member of the International College of Geriatric Psychoneuropharmacology and the Society of Neuroscience, among other organizations.

研究领域

Development of biomarkers for different stages of dementia, as markers of early detection as well as for markers of treatment response

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1. Tabuchi A, Sano K, Oh E, Tsuchiya T, Tsuda M. Modulation of AP-I Activity by Nitric Oxide (NO) in vitro: NO-Mediated Modulation of AP-I. FEBS Letters, 1994;351:123-127. 2. Ohtani K, Sakurai H, Oh E, Iwata E, Tsuchiya T, Tsuda M. Involvement of Protein Kinase C in Calcium Signaling Pathway to Activation of AP-I DNA-binding Activity Evoked via NMDA and Voltage-gated Calcium Channels. Journal of Neurochemistry, 1995;65(2):605-614. 3. Tabuchi A, Oh E, Taoka A, Sakurai H, Tsuchiya T, and Tsuda M. Rapid Attenuation of AP-I Transcriptional Factors Associated with Nitric Oxide (NO) Mediated Neuronal Cell Death. The Journal of Biological Chemistry, 1996;271:31061-31067. 4. Oh ES, Troncoso JC, Fangmark-Tucker SM. Maximizing the Potential of Plasma Amyloid-beta as a Diagnostic Biomarker for Alzheimers Disease. Neuromolecular Medicine, 2008;10(3):195-207. PMID 18543125, PMC 2558671. 5. Oh ES, Savonenko AV, King JF, Fangmark-Tucker SM, Rudow GL, Xu G, Borchelt DR, Troncoso JC, Amyloid Precursor Protein Increases Cortical Neuron Size in Transgenic Mice. Neurobiology of Aging, 2009; 30(8) 1238-44. PMID 18304698, PMC 2796369. 6. Rosenberg PB, Mielke MM, Appleby B, Oh E, Leoutsakous JM, Lyketsos CG. Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction. Int. Jr. of Geriatric Psychiatry, Epub (9/10). PMID:20845402 7. Oh ES, Mielke MM, Rosenberg PB, Jain A, Fedarko NS, Lyketsos CG, Mehta PD. Comparison of Conventional ELISA with Electrochemiluminescence Technology for Detection of Amyloid-beta (Aβ) in Plasma. J Alzheimers Dis, 2010; 21(3):769-73. PMID 20634583 PMC 255878 8. Liu Y, Lee MK, James MM, Price DL, Borchelt DR, Troncoso JC, Oh ES. Immunotherapy attenuates monoaminergic neurodegeneration in transgenic mice. J Alzheimers Dis, 2010. PMID: 20966549