Manabe, Yuka - Johns Hopkins University

个人简介

Dr. Yukari Manabe is a Professor in the Division of Infectious Diseases in the Department of Medicine with secondary appointments in the Bloomberg School of Public Health Department of International Health and the Department of Microbiology and Molecular Immunology. From 2007-2012, she was seconded to the Infectious Diseases Institute (IDI), Makerere University College of Health Sciences in Kampala, Uganda, where she was the Head of Research. Dr. Manabe obtained her undergraduate degree from Yale University and her M.D. from Columbia University College of Physicians and Surgeons. After completing both her residency in Internal Medicine and fellowship in Infectious Diseases at Johns Hopkins Hospital, she joined the faculty in 1999. Dr. Manabe has been doing operational and translational research in tuberculosis and HIV co-infection as well as evaluating TB and other point-of-care (POC) diagnostics in the IDI translational lab. Johns Hopkins has a long-standing collaboration with Makerere University and this will provide a unique opportunity to test POC STD diagnostics in a resource-limited setting/low income country where POC diagnostics are often the only ones available due to poor laboratory infrastructure. Dr. Manabe's role is to serve as the project's principal investigator and to oversee the project in the Ugandan resource-limited setting. As part of the Center for Global Health, Dr. Manabe is interested in rapid diagnostics suitable for the resource-limited settings particularly in sub-Saharan Africa (SSA). She began her career working on the basic science aspects of tuberculosis (TB) immunopathogenesis in comparative animal models of infection, particularly latency, reactivation, and immune reconstitution inflammatory syndrome (IRIS) in the rabbit model within the Johns Hopkins Center for Tuberculosis Research. In 2007, she was seconded to the Infectious Diseases Institute (IDI) at Makerere College of Health Sciences as the Associate Medical Laboratory Director of the College of American Pathologists certified Makerere University-Johns Hopkins University Clinical Core Lab to study antiretroviral associated TB and IRIS. She then became the Head of Research at the IDI in 2008 until 2012 where she built research capacity and infrastructure for training Ugandan investigators. Her research has focused on accuracy testing of various rapid, point-of-care diagnostics for HIV and related infectious diseases of clinical importance in SSA. She is also interested in studying the impact of various diagnostic interventions on disease detection and patient outcomes.

研究领域

As part of the Center for Global Health, Dr. Manabe is interested in rapid diagnostics suitable for the resource-limited settings particularly in sub-Saharan Africa (SSA). She began her career working on the basic science aspects of tuberculosis (TB) immunopathogenesis in comparative animal models of infection, particularly latency, reactivation, and immune reconstitution inflammatory syndrome (IRIS) in the rabbit model within the Johns Hopkins Center for Tuberculosis Research. In 2007, she was seconded to the Infectious Diseases Institute (IDI) at Makerere College of Health Sciences as the Associate Medical Laboratory Director of the College of American Pathologists certified Makerere University-Johns Hopkins University Clinical Core Lab to study antiretroviral associated TB and IRIS. She then became the Head of Research at the IDI in 2008 until 2012 where she built research capacity and infrastructure for training Ugandan investigators. Her research has focused on accuracy testing of various rapid, point-of-care diagnostics for HIV and related infectious diseases of clinical importance in SSA. She is also interested in studying the impact of various diagnostic interventions on disease detection and patient outcomes.

近期论文

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Manabe YC, Nonyane BAS, Nakiyingi L, Mbabazi O, Lubega G, Shah M, Moulton LH, Joloba M, Ellner J, Dorman SE. Point of care lateral flow assays for tuberculosis and cryptococcal antigenemia predict death in HIV-infected adults. (Plos One) Boulware DR, Meya DB, Muzoora C, Rolfes MA, Hullsiek KH, Musubire A, Taseera K, Nabeta HW, Schutz C, Williams DA, Rajasingham R, Rhein J, Theinemann F, Lo MW, Nielsen K, Bergemann TL, Kambugu A, Manabe YC, Janoff EN, Bohjanen PR, Meintjes G and the COAT Trial Team. Delayed antiretroviral therapy after cryptococcal meningitis improves survival. (in press NEJM) Nakiyingi L, Moodley M, Manabe YC, Nicol MP, Holshouser M, Armstrong DT, Zemanay W, Sikhondze W, Mbabazi O, Nonyane BAS, Shah M, Joloba ML, Alland D, Ellner JJ, Dorman SE. Accuracy of point-of-care urine test for tuberculosis diagnosis in HIV-infected adults. J Acquir Immune Defic Syndr. 2014 Mar 26. [Epub ahead of print]PMID:24675585 Shah M, Dowdy D, Joloba M, Ssengooba W, Manabe YC, Ellner J, Dorman SE. Cost-effectiveness of novel algorithms for rapid diagnosis of tuberculosis in HIV-infected individuals in Uganda. AIDS. 2014 Mar 15. [Epub ahead of print] PMID:24637544 Jacob, ST, Pavlinac P, Nakiyingi L, Banura P, Baeten J, Morgan K, Magaret A, Manabe Y, Reynolds SJ, Liles WC, Wald A, Joloba ML, Mayanja-Kizza H, Scheld M. Mycobacterium tuberculosis bacteremia in a cohort of HIV-infected patients hospitalized with severe sepsis in Uganda. High frequency, low clinical suspicion and derivation of a clinical prediction score. PLoS One. 2013 Aug 5;8(8):e70305. doi: 10.1371/journal.pone.0070305. Print 2013. (PMID:23940557). Kuznik A, Lamorde M, Nyabigambo A, Manabe YC. Antenatal syphilis screening using point-of care testing in sub-Saharan Africa: acost-effectiveness analysis. Plos Medicine. 2013 Nov;10(11):e1001545. doi: 10.1371/journal.pmed.1001545. Epub 2013 Nov 5. (PMID: 24223524). Albert A, Nakiyingi L, Sempa J, Mbabazi O, Mukkada S, Nyesiga B, Perkins MD, Manabe YC. Performance of LED fluorescence microscopy in screening tuberculosis suspects in an urban HIV clinic in Uganda. PLoS One. 2013 Sep 6;8(9):e72556. doi: 10.1371/journal.pone.0072556. (PMID: 24039780) Hermans SM, Nasuuna E, van Leth F, Byhoff E, Schwartz M, Hoepelman IM, Lange J, Manabe YC. Implementation and effect of intensified case finding on diagnosis of tuberculosis in a large urban HIV clinic in Uganda: a retrospective cohort study. BMC Public Health 2012;12:674 (PMID 22905704) Manabe YC, Wang Y, Elbireer A, Auerbach B, Castelnuovo B. Evaluation of a portable CD4 T cell counter with high sensitivity for detecting patients eligible for antiretroviral therapy PLoS One 2012; 7(4):e34319 (PMID 2256323) Cox JA, Lukande RL, Nelson AM, Mayanja-Kizza H, Colebunders R, Manabe YC. An autopsy study describing causes of death and comparing clinic-pathological findings among hospitalized patients in Kampala, Uganda. PLoS One. 2012; 7(3):e33685. (PMID 22432042) Worodria W., Massinga-Loembe M, Mayanja-Kizza H, Namaganda J, Kambugu A, Manabe YC, Kestens L, Colebunders R. Antiretroviral treatment (ART) associated TB in a prospective cohort of HIV-infected patients starting ART. Clin Dev Immunol. 2011:758350. Epub 2010 Dec 8. (PMID:21197091) Manabe YC, Katabira E, Brough RL, Coutinho A, Sewankambo N, Merry C. Developing independent investigators for clinical research relevant for Africa. Health Res Policy Syst. 2011 Dec 29;9:44. (PMID 22206247) Haddow LJ, Bolebunders R, Meintjes G, Lawn SD, Elliott JH, Manabe YC, Bohjanen PR, Sungkanuprph S, Easterbrook PJ, French MA, Boulware DR. Cryptococcal immune reconstitution inflammatory syndrome: literature review and proposed clinical case definitions. Lancet Infect Dis. 2010; 10(11): 791-802. (PMID: 21029993) Meya DB, Manabe YC, Castelnuovo B, Kambugu A, Cook B, Kamya M, Bohjanen P, Manabe YC, Boulware DR. Cost effectiveness of serum cryptococcal antigen (CRAG) screening to prevent death in HIV-infected persons with CD4 Hermans SM, Kiragga A, Schaefer P, Kambugu A, Hoepelman IM, Manabe YC. Post-antiretroviral therapy tuberculosis contributes to suboptimal immune reconstitution in an urban tuberculosis endemic resource-limited setting. PLoS ONE. 2010:5(5);e10527. (PMID: 20479873) Castelnuovo B, Manabe YC, Kiragga A, Kamya M, Kambugu A. Cause-specific mortality and the contribution of immune reconstitution inflammatory syndrome in the first three years after antiretroviral therapy in an urban African cohort. Clin Infect Dis.2009;49(6):965-972. (PMID: 19673615) Manabe YC, Jacob ST, Thomas D, Quinn TC, Ronald A, Coutinho A, Mayanja-Kizza H, Merry C. Resurrecting the triple threat—Academic Social Responsibility in the context of global health. Clin Infect Dis. 2009 May 15;48(10):1420-2. (PMID: 19368501) Manabe YC, Breen R, Perti T, Girardi E, Sterling T. Unmasked Tuberculosis and Tuberculosis Immune Reconstitution Inflammatory Disease: a Disease Spectrum after Antiretroviral Therapy Initiation. J Infect Dis. 2009 Feb 1;199(3):437-44. (PMID: 19090776) Manabe YC, Kesavan AK, Lopez-Molina J, Hatem CL, Brooks M, Fujiwara R., Hochstein K, Pitt MLM, Tufariello J, Chan J, McMurray DN, Dannenberg AM, Jr., Mendez S. The aerosol rabbit model of tuberculosis latency, reactivation and immune reconstitution inflammatory syndrome. Tuberculosis 2008;88(3):187-96. (PMID: 18068491) Manabe YC, Campbell JD, Sydnor ES, Moore RD. Immune Reconstitution Inflammatory Syndrome: Risk Factors and Treatment Implications JAIDS 2007 Dec 1;46(4):456-62. (PMID:18077835) Kesavan AK, Mendez SE, Hatem CL, Lopez-Molina J, Aird K, Pitt MLM, Dannenberg AM, Jr., Manabe YC. Effects of Dexamethasone and Transient Malnutrition on Rabbits Infected by Aerosolized Mycobacterium tuberculosis CDC1551 Infect Immun 2005; 73(10): 7056-60. (PMID: 16177392) Dorman S, Hatem CL, Tyagi S, Aird K, Lopez-Molina J, Pitt MLM, Zook BC, Dannenberg, AM Jr., Bishai WR, Manabe YC. Susceptibility to tuberculosis: clues from studies with inbred and outbred New Zealand White rabbits. Infect Immun 2004; 72(3): 1700-1705. PMID: 14977978) Manabe YC & Bishai WR. Latent Mycobacterium tuberculosis -- persistence, patience, and winning by waiting. Nature Med 2000; 6: 1327-1329. (PMID: 11100115) Manabe YC, Saviola BJ, Sun L, Murphy JR, Bishai WR. Attenuation of virulence in Mycobacterium tuberculosis expressing a constitutively active iron repressor. Proc Natl Acad Sci USA 1999; 96: 12844-12848. (PMID:10536010) Manabe YC, Clark DP, Moore RD, Lumadue J, Dahlman HR, Belitsos PC, Chaisson RE, Sears CL. Cryptosporidiosis in AIDS: correlates of disease and survival. Clin Infect Dis 1998; 27: 536-42. (PMID: 9770154)