King, Landon - Johns Hopkins University

个人简介

As Executive Vice Dean for the Johns Hopkins University School of Medicine, Dr. King oversees research administration, policy coordination, and the identification and coordination of technology transfer opportunities. He assists Dean Rothman in overseeing operations and program development in the School of Medicine. Dr. King received his medical degree in 1989 from Vanderbilt University and first came to Hopkins that year as an intern in the Osler Medical Service. As a postdoctoral fellow and later, after joining the faculty as an assistant professor in 1997, he undertook important studies of water channels in the lung with 2003 Nobel Laureate Peter Agre. In 2005, he was selected to be the Director of the Division of Pulmonary and Critical Care Medicine. He was elected to the American Society for Clinical Investigation in 2006 for work on aquaporin water channels. His work currently focuses on mechanisms regulating repair of lung injury. MD; Medicine, Vanderbilt University School of Medicine (1989)

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1. Biaggioni I, King LS, Enayat N, Robertson D, Newman JH. 1989. Adenosine produces pulmonary vasoconstriction in sheep: Evidence for thromboxane A2- prostaglandin endoperoxide receptor activation. Circ Res. 65(6):1516-1526. 2. Duke SS, King LS, Jones M, Newman JH, Brigham KL, Forbes J. 1989. Human recombinant interleukin-2 activated sheep lymphocytes lyse sheep pulmonary microvascular endothelial cells. J Cell Immunol. 122:188-199. 3. King LS, Fukushima M, Banerjee M, Kang KH, Newman JH, Biaggioni I. 1991. Pulmonary vascular effects of prostaglandin D2 but not its systemic vascular or airway effects are mediated through thromboxane receptor activation. Circ Res. 68(2):352-358. 4. Fukushima M, King LS, Kang KO, Banerjee M, Newman JH. 1990. Lung mechanics and airway reactivity in sheep during the development of oxygen toxicity. J App Physiol. 69(5):1779-1785. 5. Kubo K, King LS, Kobayashi T, Newman JH. 1992. Differing effects of nitrogen mustard and hydorxyurea on lung O2 toxicity in adult sheep. Am. Rev. Resp.Dis. 145:13-18. 6. Newman JH, Cochran CP, Roselli RJ, Parker RE, King LS. 1993. Pressure and flow changes in the pulmonary circulation in exercising sheep: evidence for elevated microvascular pressure. Am Rev Resp Dis. 147:921-926. 7. King LS, Nielsen S, Agre P. 1996. Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat. J Clin Invest. 97:2183-91. 8. King LS, Nielsen S, Agre P. 1997. Aquaporins in complex tissues: I. Developmental patterns in respiratory tract and glandular tissue of rat. Am J Physiol Cell 273:C1541-48. 9. Nielsen S, King LS, Christensen BM, Agre P. 1997. Aquaporins in complex tissues: II. Cellular and subcellular distribution in respiratory tract and glands of rat. Am J Physiol Cell 273:C1549-61. 10. Moon C, King LS, Agre P. 1997. Expression of Aquaporin-1 water channel protein in mouse erythro-leukemia cells: genetic regulation of corticosteroid and chemical induction. Am J Physio. Cell 273:C1562-70. 11. Lee MD, King LS, Nielsen S, Agre P. 1997. Genomic organization and developmental expression of aquaporin-5 in lung. Chest. 111:111S-113S. 12. Borok Z, Lubman RL, Danto SI, Zhang X-L, Zabski SM, King LS, Agre P, Crandall ED. 1998. Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin-5 (AQP5). Am J Resp Cell Mol Biol. 18:554-61 13. Hoffert J, Leitch V, Agre P, King LS. 2000. Hypertonic induction of AQP5 expression through an ERK dependent pathway. J Biol Chem. 275:9070-9077 14. Steinfeld S, Cogan E, King LS, Agre P, Kiss R, Delporte C. 2001. Abnormal distribution of AQP5 water channel protein in salivary glands from Sjgrens syndrome patients. Lab Invest. 81:143-148 15. Tsubota K, Hirai S, King LS, Agre P, Ishida N. 2001 Defective cellular trafficking of aquaporin-5 water channel protein in Sjgrens syndrome lacrimal glands. Lancet, 357:688-689. 16. Leitch V, Agre P, King LS. 2001. Altered ubiquitination and stability of aquaporin-1 in hypertonic stress. Proc Natl Acad Sci USA, 98:2894-2898. 17. King LS, Choi M, Cartron J-P, Agre P. 2001. Defective urinary concentrating ability due to a complete deficiency of aquaporin-1. N Engl J Med. 345:175-179 18. Nejsum LN, Kwon T-H, Jensen UB, Fumagalli O, Frokiaer J, Krane CM, Menon AG, King LS, Agre P, Nielsen S. 2001. Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Proc Natl Acad Sci. 99:511-516. 19. King L, Nielsen S, Agre P, Brown R. 2002. Decreased pulmonary vascular permeability in aquaporin-1 null humans. Proc Natl Acad Sci. 99:1059-1063. 20. Kozono D, Yasui, M, King LS, Agre P. 2002. Aquaporin water channels: atomic structure and molecular dynamics meet clinical medicine. J Clin Invest. 109:1395-1399. 21. Gresz V, Kwon T-H, Gong H, Agre P, Steward M, King LS, Nielsen S. 2004. Immunolocalization of AQP5 in rat parotid and submandibular salivary glands after stimulation or inhibition of secretion in vivo. Am J Physiol. 287:G151-161. 22. Herrlich A, Leitch V, King LS. 2004. Proneuregulin-1 cleavage and human epidermal growth factor receptor activation, early steps in hypertonic extracellular signal-regulated kinase activation and aquaporin expression. Proc Natl Acad Sci USA 101:15799-15804. 23. Sidhaye V, Hoffert, J, King LS. 2005. cAMP regulation of aquaporin-5: distinct acute and chronic effects in lung epithelial cells. J Biol Chem 280(5):3590-3596. 24. Molls RR, Savransky V, Liu M, Bevans S, Mehta T, Tuder RM, King LS, Rabb H. 2006. Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury. Am J Physiol Renal Physiol. 290(5):F1187-1193. 25. Sidhaye VK, Guler AD, Schweitzer KS, DAlessio F, Caterina MJ, King LS. 2006. Transient receptor potential vailloid 4 regulates aquaporin-5 abundance under hypotonic conditions. Proc Nat Acad Sci USA 103(12):4747-4752.