个人简介

Dr. Petros Karakousis is an associate professor of medicine at the Johns Hopkins University School of Medicine. He has a joint appointment in international health at the Johns Hopkins Bloomberg School of Public Health. His areas of clinical expertise include infectious diseases and tuberculosis. Dr. Karakousis received his undergraduate degree in 1994 from the Johns Hopkins University and his medical degree in 1998 from Washington University School of Medicine in St. Louis. He completed residency training in internal medicine in 2001 at the Hospital of the University of Pennsylvania. After completing fellowship training in infectious diseases at Johns Hopkins, he joined the Department of Medicine faculty in 2005. His research interests include Mycobacterium tuberculosis latency and persistence. Dr. Karakousis is a board member for the Hopkins Hellenic Initiative. He serves as an academic editor for PLoS One and is on the editorial advisory board of the Journal of Infectious Diseases. He is a member of the American Thoracic Society, the American Society for Microbiology, the Infectious Disease Society of America and the American College of Physicians. MD, Washington University School of Medicine in St Louis (1998)

研究领域

Mycobacterium tuberculosis latency and persistence

Dr. Karakousis’ primary research interest is the molecular basis of Mycobacterium tuberculosis latency and reactivation. Secondary interests include preclinical screening of novel TB drugs and drug combinations in animal models of caseous necrosis, as well as development of novel molecular assays for the rapid diagnosis of latent TB infection and active TB disease, and for the detection of drug resistance.

近期论文

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Levine DM, Dutta NK, Eckels J, Scanga C, Stein C, Mehra S, Kaushal D, Karakousis PC, Salamon H. "A tuberculosis ontology for host systems biology." Tuberculosis. 2015;95(5):570-574. Subbian S, Tsenova L, Kim M-J, Wainwright HC, Visser A, Bandyopadhyay N, Bader JS, Karakousis PC, Murrmann GB, Bekker LG, et al. "Lesion-specific immune response in granulomas of patients with pulmonary tuberculosis: A pilot study." PLoS ONE. 2015;10(7). Xu Z, Zhou A, Ni J, Zhang Q, Wang Y, Lu J, Wu W, Karakousis PC, Lu S, Yao Y. "Differential expression of miRNAs and their relation to active tuberculosis." Tuberculosis. 2015;95(4):395-403. Zhou A, Ni J, Xu Z, Wang Y, Zhang H, Wu W, Lu S, Karakousis PC, Yao Y-F. "Metabolomics specificity of tuberculosis plasma revealed by 1(H) NMR spectroscopy." Tuberculosis. 2015;95(3):294-302. Chuang Y-M, Bandyopadhyay N, Rifat D, Rubin H, Bader JS, Karakousis PC. "Deficiency of the novel exopolyphosphatase Rv1026/PPX2 leads to metabolic downshift and altered cell wall permeability in Mycobacterium tuberculosis." mBio. 2015;6(2).