个人简介

Dr. David R.M. Graham is an assistant professor of molecular and comparative biology at the Johns Hopkins University School of Medicine. He holds a secondary appointment in the Division of Cardiology. Additionally, he serves as the School of Medicine Executive Director for the Center for Resources in Integrative Biology, a School of Medicine and School of Public Health joint faculty initiative. His research focuses on understanding the consequences of HIV interactions with the immune system, the resulting pathogenesis and how to sabotage these interactions. Dr. Graham completed his undergraduate studies in biomedical and health sciences at the University of Guelph and his master’s work in biology at McMaster University, both in Ontario, Canada. After a two-year break from academics, he relocated to Baltimore and returned to graduate school at Johns Hopkins, where he obtained his Ph.D. in biochemistry, cellular and molecular biology. In 2004, he joined the faculty of Johns Hopkins as a research associate in the Division of Cardiology, and in 2009 he became an assistant professor. Dr. Graham is a member of several professional societies and serves on the editorial boards of PROTEOMICS and Frontiers Immunology. He has published more than two dozen peer reviewed articles and one book chapter, and has presented his work at several national and international conferences. . He has served as co-investigator or co-principal investigator on several research grants funded by the National Institutes of Health, and holds one patent. B.S., University of Guelph (Canada) (1995) M.S., McMaster University Michael G. DeGroote School of Medicine (Canada) (1998) Ph.D., Johns Hopkins University School of Medicine (Maryland) (2004)

研究领域

High technology development; Cardiovascular disease; H/SIV pathogenesis, and neuropathogenesis

Dr. Graham merges his research in cardiology and virology to study HIV-induced cardiomyopathy, an important emerging area in cardiovascular medicine. His research in virology is concentrated on understanding the differences between viruses with divergent pathologies, including the ability to differentially induce apoptosis by a IFN a/B induced expression of TRAIL, in collaboration with Gene Shearer (NIH) and Jean-Phillipe Herbeuval (Necker Institute, France), and viruses with the ability to induce neurotoxicity in collaboration with Drs. Zink and Clements (retrovirus laboratory). In cardiology, Dr. Graham focuses on the molecular phenotyping of transgenic rabbits over expressing alpha-myosin heavy chain, which has been shown to be cardioprotective against pacing induced heart failure. In this complex experimental model, Dr. Graham has been able to elucidate changes in the proteome caused by the transgene alone as compared to the background strain and differences between all groups under pacing induced heart failure. He has been collaborating on an investigation of the role of lipid rafts in the control of SA nodal cell function, and has developed ultra-sensitive mass-spectrometry methods to compare compositional changes in the lipid raft proteome between control and stimulated SA nodal cells.

近期论文

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Brown, J.M., N.J. Shaw, and D.R. Graham. "The first five years: a mixed methods study investigating reflections on working as a hospital consultant." JRSM Short Rep, 2013. 4(5): p. 2042533313476686. Linde, M.E., et al. "The conserved set of host proteins incorporated into HIV-1 virions suggests a common egress pathway in multiple cell types." J Proteome Res, 2013. 12(5): p. 2045-54. Nzowa, L.K., et al. "Two new tryptophan derivatives from the seed kernels of Entada rheedei: effects on cell viability and HIV infectivity." Fitoterapia, 2013. 87: p. 37-42. Tavano, B., et al. "Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes." J Immunol, 2013. 190(6): p. 2622-30. Tovar, Y.R.L.B., et al. "Adenosine Triphosphate Released from HIV-Infected Macrophages Regulates Glutamatergic Tone and Dendritic Spine Density on Neurons." J Neuroimmune Pharmacol, 2013.