个人简介

Dr. Grader-Beck is an Assistant Professor of Medicine in the Rheumatology Division. Dr. Grader-Beck’s clinical interests include systemic lupus erythematosus and Sjögren’s syndrome, with emphasis on complex patients that are difficult to treat, as well as patients with vaginal sicca. MD, Heidelberg University School of Medicine (1997)

研究领域

Pathogenesis of systemic autoimmune diseases, systemic lupus erythematosus and Sjogren''s

His research interests include systemic lupus erythematosus and Sjögren’s syndrome. The pathogenesis of SLE and Sjogren’s syndrome, two closely related and common systemic autoimmune diseases, remains unknown. Antibodies that target self-molecules (autoantibodies) are thought to play an important role in the disease process. Dr. Grader-Beck’s laboratory is investigating mechanisms that may render self-structures immunogenic and hypothesizes that specific posttranslational modifications of antigens that may occur during infections or malignant transformation lead to expression of neoepitopes that propagate autoimmunity in the right setting. By combining studies using a variety of mouse strains, specific gene-deficient mice as well as human biological specimens, Dr. Grader-Beck’s team is taking a translational approach to answer these questions.

近期论文

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Mathews PM, Hahn S, Hessen M, Kim J, Grader-Beck T, Birnbaum J, Baer AN, Akpek EK. Ocular Complications of Primary Sjögren Syndrome in Men. Am J Ophthalmol. Akpek EK, Mathews P, Hahn S, Hessen M, Kim J, Grader-Beck T, Birnbaum J, Baer AN. Ocular and systemic morbidity in a longitudinal cohort of Sjögren's syndrome. Grader-Beck T, Boin F, von Gunten S, Smith D, Rosen A, Bochner BS. Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease. Ann Rheum Dis. 2011 O'Shaughnessy MJ, Chen ZM, Gramaglia I, Taylor PA, Panoskaltsis-Mortari A, Vogtenhuber C, Palmer E, Grader-Beck T, Boussiotis VA, Blazar BR. Elevation of intracellular cyclic AMP in alloreactive CD4(+) T Cells induces Park JK, Subhawong AP, Ziminski CM, Grader-Beck T. Dermatomyositis as the initial presentation of a large anaplastic T-cell lymphoma. J Clin Oncol. 2011 Grader-Beck T, Casciola-Rosen L, Lang TJ, Puliaev R, Rosen A, Via CS. Apoptotic splenocytes drive the autoimmune response to poly(ADP-ribose) Grader-Beck T, Wigley FM. Raynaud's phenomenon in mixed connective tissue disease. Rheum Dis Clin North Am. 2005 Aug;31(3):465-81, vi. Review. PubMed PMID: Grader-Beck T, van Puijenbroek AA, Nadler LM, Boussiotis VA. cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression. Blood. 2003 Feb Appleman LJ, Tzachanis D, Grader-Beck T, van Puijenbroek AA, Boussiotis VA. Helper T cell anergy: from biochemistry to cancer pathophysiology and therapeutics. J Mol Med (Berl). 2001;78(12):673-83. Review. PubMed PMID: Appleman LJ, Tzachanis D, Grader-Beck T, Van Puijenbroek AA, Boussiotis VA. Induction of immunologic tolerance for allogeneic hematopoietic cell transplantation. Leuk Lymphoma. 2002 Jun;43(6):1159-67. Review. PubMed PMID: