个人简介

Dr. Jed W. Fahey is an assistant professor of medicine and of pharmacology and molecular sciences at the Johns Hopkins University School of Medicine. He holds a joint appointment in international health at the Johns Hopkins Bloomberg School of Public Health. His research focuses on phytochemistry and the nutrition-based prevention of chronic disease. A recognized nutritional biochemist with expertise in plant physiology, human nutrition, phytochemistry and nutritional biochemistry, Dr. Fahey leads The Lewis B. and Dorothy Cullman Chemoprotection Center. His team is currently focused on the induction by phytochemicals of cytoprotective, anti-inflammatory and antioxidant responses in mammalian systems. Dr. Fahey received his B.A. from Johns Hopkins. He earned an M.S. in plant physiology from the University of Maryland, College Park and an Sc.D. in human nutrition at the Johns Hopkins Bloomberg School of Public Health. Dr. Fahey joined the Johns Hopkins faculty in 1993. Prior to joining Johns Hopkins, Dr. Fahey spent 15 years in the biotechnology industry, where he held senior management positions in agricultural biotechnology research and process development. B.A., Johns Hopkins University (Maryland) (1975) M.S., University of Maryland (College Park) (Maryland) (1978) Sc.D., Johns Hopkins Bloomberg School of Public Health (Maryland) (2004)

研究领域

Nutrition-based prevention of chronic disease; Diet; Disease prevention; Phytochemistry; Chemoprotection; Chemoprevention; Cancer; Crucifer; Brassica; Glucosinolate

Dr. Fahey’s research is aimed at developing nutritional strategies for chronic disease prevention in humans and draws from natural product chemistry, enzymology, nutritional epidemiology and clinical research. Many studies examine the glucosinolates and isothiocyanates found in cruciferous vegetables and in Moringa oleifera (“the drumstick tree”). Dr. Fahey and his colleagues discovered that broccoli sprouts are a rich source of inducers of the enzymes that detoxify carcinogens (PNAS 94:10367-10372). They determined that two of the inducers—sulforaphane in broccoli and isothiocyanate in Moringa oleifera—have potent antibiotic activity against Helicobacter pylori, which can cause peptic ulcer disease and stomach cancer. Dr. Fahey’s other research looks at flavonoid and phenolic secondary metabolites from plants that include ginseng, honey, ginger, ashwagandha and black cohosh.

近期论文

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Liu H, Talalay P, Fahey JW. "Biomarker-guided strategy for treatment of autism spectrum disorder (ASD)." CNS Neurol Disord Drug Targets. 2016 Apr 13. [Epub ahead of print] An SS, Mitzner W, Tang WY, Ahn K, Yoon AR, Huang J, Kilic O, Yong HM, Fahey JW, Kumar S, Biswal S, Holgate ST, Panettieri RA Jr, Solway J, Liggett SB. "An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma." J Allergy Clin Immunol. 2016 Feb 27. pii: S0091-6749(16)00116-0. doi: 10.1016/j.jaci.2015.12.1315. [Epub ahead of print] No abstract available. Fahey JW, Holtzclaw WD, Wehage SL, Wade KL, Stephenson KK, Talalay P. "Sulforaphane bioavailability from glucoraphanin-rich broccoli: control by active endogenous myrosinase." PLoS One. 2015 Nov 2;10(11):e0140963. doi: 10.1371/journal.pone.0140963. eCollection 2015. Brown RH, Reynolds C, Brooker A, Talalay P, Fahey JW. "Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways." Respir Res. 2015 Sep 15;16:106. doi: 10.1186/s12931-015-0253-z. Knatko EV, Ibbotson SH, Zhang Y, Higgins M, Fahey JW, Talalay P, Dawe RS, Ferguson J, Huang JT, Clarke R, Zheng S, Saito A, Kalra S, Benedict AL, Honda T, Proby CM, Dinkova-Kostova AT. "Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans." Cancer Prev Res (Phila). 2015 Jun;8(6):475-86. doi: 10.1158/1940-6207.CAPR-14-0362. Epub 2015 Mar 24.