个人简介

Dr. Stephen Desiderio is a professor of molecular biology and genetics at the Johns Hopkins University School of Medicine. His research focuses on the molecular and genetic mechanisms underlying immune system development. Dr. Desiderio serves as the director of the Institute for Basic Biomedical Sciences and director of the immunobiology program at the Institute of Cell Engineering (ICE). Dr. Desiderio’s research team has made numerous contributions to our understanding of how immunity develops in health and disease. Their studies have shed light on the relationship between genetic rearrangement—the process by which immune diversity is generated—and the development of leukemia. They have discovered key elements of the triggers that turn on immune responses, and most recently have focused on the signals that instruct stem cells to become cells of the immune system. Dr. Desiderio received his undergraduate degree in biology and Russian from Haverford College. He earned his Ph.D. and M.D. from the Johns Hopkins University School of Medicine. He completed a postdoctoral fellowship at the Massachusetts Institute of Technology. Dr. Desiderio joined the Johns Hopkins faculty in 1984. From 1984 to 2004, Dr. Desiderio was an investigator of the Howard Hughes Medical Institute. From 1992 to 1999, he was director of the M.D.-Ph.D. program at the Johns Hopkins School of Medicine. Dr. Desiderio is a member of several professional societies and has been honored by election to the Association of American Physicians and the American Society for Clinical Investigation. He is a member of the Johns Hopkins Kimmel Cancer Center and serves on the editorial board of the Journal of Molecular Medicine. In 2007, the governor appointed him to the Maryland Life Sciences Advisory Board. M.D., Johns Hopkins University School of Medicine (Maryland) (1981) Ph.D., Johns Hopkins University School of Medicine (Maryland) (1981)

研究领域

Genomic plasticity; DNA recombination; immune development; lymphoid malignancies

Dr. Desiderio's research focuses on the molecular and genetic mechanisms responsible for development of the immune system. His research has shed light on how the immune system is able to respond to a spectacularly diverse set of invaders. His team’s studies have helped explain the relationship between genetic rearrangement—the process by which immune diversity is generated—and the development of leukemia. The team has also discovered key elements of the triggers that turn on immune responses, and most recently has turned its attention to signals that instruct stem cells to become cells of the immune system.

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Yoo, J.-Y., Huso, D.L., Nathans, D. and Desiderio, S. (2002) Specific ablation of Stat3ß distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock. Cell 108:331-344. Jiang, H., Chang, F.-C., Ross, A.E., Lee, J., Nakayama, K., Nakayama, K. and Desiderio, S. (2005) Ubiquitylation of RAG-2 by SKP2-SCF links destruction of the V(D)J recombinase to the cell cycle. Mol. Cell, 18(6): 699-709 Liu Y, Subrahmanyam R, Chakraborty T, Sen R, Desiderio S. (2007) A plant homeodomain in RAG-2 that binds hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement. Immunity 27:561-71. Zhang, L., Reynolds, T.L., Shan, X. and Desiderio, S. (2011) Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis. Immunity 34: 163-174. Lu C., Ward A., Bettridge J., Liu Y., Desiderio S. (2015) An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation. Cell Rep. Jan 6;10(1):29-38