个人简介

Dr. Shukti Chakravarti, Professor of Medicine (Gastroenterology division), Ophthalmology and Cell Biology studies extracellular matrix mediated regulation of inflammation and tissue homeostasis in the eye and inflammatory bowel diseases. Dr. Chakravarti holds a bachelor's degree from Lady Brabourne College and a master's and PhD from the University of Pittsburgh. She completed a fellowship at the University of Pittsburgh before joining the Johns Hopkins faculty in 2000. She is the section Editor for Experimental Eye Research and is on the Editorial board of PlosOne. B.S., Lady Brabourne College (India) (1978) M.S., University of Pittsburgh (Pennsylvania) (1983) Ph.D., University of Pittsburgh (Pennsylvania) (1989)

研究领域

Extracellular matrix and tissue homeostasis; Ulcerative colitis; Crohn's disease

The Shukti Chakravarti Laboratory is interested in the regulation of cellular functions and tissue homeostasis by the extracellular matrix (ECM). The laboratory investigates functions of collagen-associated extracellular matrix proteins and proteoglycans, lumican, fibromodulin and biglycan in maintaining connective tissue architecture and cellular functions. Lumican regulates collagen fibril structure such that gene targeted mice deficient in lumican manifest Ehlers Danlos Syndrome-like skin fragility, tendon weaknesses and corneal opacity. These ECM proteins also regulate host innate immune responses by interacting with toll-like receptor (TLR) signals to promote sensing of pathogen-associated molecular patterns, or presenting as danger signals themselves. Our investigation of the ECM centers on two barrier tissues, the cornea of the eye and the intestinal mucosa and submucosa.

近期论文

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1. Chakravarti S, Magnuson T, Lass JH, LaMantia C, Jepsen KJ, Carroll H. Collagen fibril defects affecting skin and cornea in lumican-deficient mice. J Cell Biol. 1277-1286. PubMed PMID: 9606218;PubMed Central PMCID: PMC2137175. 2. Lawrance IC, Fiocchi C, Chakravarti S. 2001. Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes.Hum Mol Genet.10:445 PMID:11181568. 3. Lawrance IC, Wu F, Leite AZA, Willis J,West GA, Fiocchi C, Chakravarti S. A murine model of chronic inflammation-induced intestinal fibrosis down regulated by antisense NF-?B. Gastroenterology. 2003; 125: 1750-1761. PubMed PMID: 14724828. 4: Wu F, Vij N, Roberts L, Lopez-Briones S, Joyce S, Chakravarti S. 2007a. A novel role of the lumican core protein in bacterial lipopolysaccharide-induced innate immune response. J Biol Chem. 282:26409. PMID:17616530. 5. Wu, F. and Chakravarti, S. 2007b. Differential Expression of Inflammatory and Fibrogenic Genes and Their Regulation by NF-{kappa}B Inhibition in a Mouse Model of Chronic Colitis. J Immunol.179: 6988. 6. Lee, S., Bowrin, K., Hamad, A. and Chakravarti, S. 2009a Extracellular matrix lumican deposited on the surface of neutrophils promotes migration by binding to ?2 integrin. J. Biol. Chem. 284:23662-9.PMID: 19531489. 7. Ghosh A, Lee S, Dziarski R, Chakravarti S. 2009b A novel antimicrobial peptidoglycan recognition protein in the cornea. Invest Ophthalmol Vis Sci. 2009 Apr 22. [Epub ahead of print] PubMed PMID: 19387073. 8. Lohr, K, Sardana, H, Lee, S, Wu, F, Huso, DL, Hamad, AR, Chakravarti, S.Extracellular matrix protein lumican regulates inflammation in a mouse model of colitis. Inflamm Bowel Diseases, 2011 Apr 11. doi: 10.1002/ibd.21713. [Epub ahead of print]. PMID: 21484968; PubMed Central PMCID: 3135758. 9. Scott S-G, Jun AS and Chakravarti S. Sphere formation from corneal keratocytes and phenotype specific markers. Experimental Eye Research, 2011 Dec;93(6):898-905. Epub 2011 Oct 21. PMID: 22032988 PMCID: 3225580. 10. Shao H, Lee S, Gae-Scott S, Nakata C, Chen S, Hamad AR, Chakravarti S. Extracellular matrix lumican promotes bacterial phagocytosis and Lum-/- mice show increased Pseudomonas aeruginosa lung infection severity. J Biol Chem. 2012 Aug 3. [Epub ahead of print] PubMed PMID: 22865855 PMCID: 3476255. 11. Shao H, Scott SG, Nakata C, Hamad AR, Chakravarti S. Extracellular matrix protein lumican promotes clearance and resolution of Pseudomonas aeruginosa keratitis in a mouse model. PLoS One. 2013;8(1):e54765. doi: 10.1371/journal.pone.0054765. Epub 2013 Jan 24. PubMed PMID: 23358433; PubMed Central PMCID: PMC3554612.