个人简介

Brendan J. Canning, Ph.D. is currently an Associate Professor of Medicine at The Johns Hopkins University School of Medicine in Baltimore, Maryland. He joined the Division of Allergy and Clinical Immunology of the Department of Medicine in 1996. He is Co-Editor-in-Chief of Cough, an Associate Editor for the Journal of Pharmacology and Experimental Therapeutics and an Associate Editor for Frontiers in Respiration Physiology. Dr. Canning has served as a scientific advisory board member and a consultant for many pharmaceutical and biotech companies. B.S., University of Maryland (College Park) (Maryland) (1986) Ph.D., Johns Hopkins Bloomberg School of Public Health (Maryland) (1993)

研究领域

Airway reflexes; Innervation of the airways; Airway defensive reflexes

We study airway neural control. We have characterized the CNS pathways regulating airway defensive reflexes and the interactions amongst various afferent nerve subtypes in regulating these reflexes. Our experimental approaches include electrophysiological recordings, CNS microinjection techniques, in vivo preparations for monitoring cough and reflex bronchospasm, neuronal tracing and immunohistochemistry.

近期论文

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Kesler, BS and BJ Canning (1999). Regulation of baseline cholinergic tone in guinea-pig airway smooth muscle. J Physiol (Lond.), 518: 843-856. View on Pubmed Canning, BJ, SM Reynolds and SB Mazzone (2001). Multiple mechanisms of reflex bronchospasm in guinea pigs. J Appl Physiol, 91(6): 2642-2653. View on Pubmed Mazzone, SB and BJ Canning (2002). Evidence for differential reflex regulation of cholinergic and noncholinergic parasympathetic nerves innervating the airways. Am J Respir Crit Care Med, (8), 1076-1083. View on Pubmed Mazzone, SB and BJ Canning (2002). Synergistic interactions between airway afferent nerve subtypes mediating reflex bronchospasm in guinea pigs. Am J Physiol (Regul Integr Comp Physiol), 283, R86-R98. View on Pubmed Canning, BJ, SM Reynolds, LU Anukwu, R Kajekar and AC Myers (2002). Endogenous neurokinins facilitate synaptic neurotransmisssion in guinea pig airway parasympathetic ganglia. Am J Physiol (Regul Integr Comp Physiol), 283, R320-R330. View on Pubmed Canning, BJ, SB Mazzone, SN Meeker, SM Reynolds and BJ Undem (2004). Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetised guinea-pigs. J. Physiol., 557 (2), 543-558. View on Pubmed