个人简介

Dr. Paul Bottomley is a Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science. He is also a Professor of Medicine in the Division of Cardiology School of Medicine, a Professor in the Biomedical Engineering School of Medicine and a Professor in Electrical and Computer Engineering. Dr. Bottomley serves as the Director of MR Research. His research focuses on the development and evaluation of magnetic resonance (MR) techniques. Dr. Bottomley received his undergraduate degree in physics at Monash University, Victoria, Australia, and earned his Ph.D. in Physics and NMR imaging at Nottingham University in England. He was awarded the Coolidge Fellowship in MRC Magnetic Resonance Unit at John Radcliffe Hospital in 1993. Dr. Bottomley joined the Johns Hopkins faculty in 1994. Prior to joining Johns Hopkins, Dr. Bottomley participated in the building and testing of perhaps the first human MRI system in Nottingham, England. He is a member of the Board of Directors for Surgi-Vision Inc. and the International Society of Magnetic Resonance in Medicine. Dr. Bottomley was awarded the Society of Magnetic Resonance in Medicine''s Gold Medal for his contributions to MRI in 1989. He has published about 170 peer-reviewed papers and holds more than 30 patents.

研究领域

New biomedical imaging modalities; Molecular imaging; High-speed cardiovascular NMR imaging

Dr. Bottomley’s research focuses on the application of nuclear magnetic resonance (NMR) techniques to biophysical, biological and medical problems. He pursues the theoretical, experimental and technical development of NMR imaging (MRI); the development of methods for spatially localized spectroscopy (MRS) and the measurement of relaxation times, diffusion constants, metabolite concentrations, kinetic reaction rates, energy supply and work in biological tissues using NMR. He’s also interested in the application of these technologies to the noninvasive study of human disease, especially heart disease. Specifically, Dr. Bottomley researches the effects of measurements of energy metabolites and metabolic fluxes with phosphorus (31P) and proton (1H) MRS in patients with ischemia, infarction and heart failure as well as sodium (23Na) MRI in patients with ischemic disease, and with cancer. Additionally, he investigates measurements of energy metabolites and metabolic fluxes with phosphorus (31P) and proton (1H) MRS in patients with ischemia, infarction and heart failure; sodium (23Na) MRI in patients with ischemic disease, and with cancer; stress testing for ischemia using 31P MRS; MRI detector coil design, phased-array detector coils including new strip detectors; and the development of new intravascular and internal MRI coils for imaging vascular and endothelial disease, and MRI-guided therapy delivery.

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Qian D, El-Sharkawy AEM, Atalar E, Bottomley PA. "Interventional MRI: Tapering Improves the Forward-Looking Properties of the Loopless Antenna." Magn Reson Med 2010; 63: 797-802. NIHMSID # 190764 Ruiz-Cabello J, Barnett BP, Bottomley PA, Bulte JWM. "Fluorine (19F) MRS and MRI indicine." NMR in Biomedicine 2010 (in press). Schar M, El-Sharkawy AEM, Weiss RG, Bottomley PA. "Triple Repetition Time Saturation Transfer (TRiST) 31P Spectroscopy for Measuring Human Creatine Kinase Reaction Kinetics." Magnetic Resonance in Medicine; 63: 1493-1501. Bottomley PA, Kumar A, Edelstein WA, Allen JM, Karmarkar PV. "Designing passive MRI-safe implantable conducting leads with electrodes." Med Phys 2010; 37: 3828-3843. Sathyanarayana S, Schar M, Kraitchman DL, Bottomley PA. "Real time MRI Endoscopy." J Am Coll. Cardiol. Cardiovasc. Imag (in press, 2010). Hinshaw WS, Bottomley PA, Holland GN. "Radiographic thin section image of the human wrist by nuclear magnetic resonance". Nature 1977; 270: 722-723. Nunnally RL, Bottomley PA. "Assessment of pharmacological treatment of myocardial infarction by phosphorous-31 NMR with surface coils". Science 1981; 211: 177-180. Bottomley PA, Hart HR, Edelstein, Schenck JF, Smith LS, Leue WM, Mueller OM, Redington RW. "NMR imaging/spectroscopy system to study both anatomy and metobolism". The Lancet 1983; ii (322), 273-274. Bottomley PA, Foster TH, Argersinger RE, Pfeifer LM. "A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms: dependence on tissue type, NMR frequency, temperature, species, excision, and age." Med Phys 1984; 11: 425-448. Bottomley PA, TH Foster, WM Leue. "Chemical imaging of the brain by NMR". Lancet 1984; I (323): 1120. Bottomley PA. "Non-invasive study of high-energy phosphate metabolism in the human heart by depth resolved 31P NMR spectroscopy". Science 1985; 229: 769-772. Bottomley PA, Weiss RG. Noninvasive MRS detection of localized creatine depletion in non-viable, infarcted myocardium. The Lancet 1998; 351: 714-718. McCaffrey RJ, Cousins JP, Westervelt HJ, Martynowicz M, Remick SC, Szebenyi S, Wagle WA, Bottomley PA, Hardy CJ, Haase RF. Practice effects with the NIMH AIDS abbreviated neuropsychological battery. Arch Clin Neuropsych 1995; 10: 241-250. Ouwerkerk R, Bottomley PA, Solaiyappan M, Spooner A, Tomaselli G, Wu KC, Weiss RG. Tissue sodium concentration in myocardial infarction in humans: A quantitative 23Na MR imaging study. Radiology 2008: 248; 88-96. Bottomley PA*, Panjrath GS*, Lai S, Hirsch GA, Wu K, Najjar SS, Steinberg A, Gerstenblith G Weiss RG. Metabolic Rates of ATP Transfer Through Creatine Kinase (CK flux) Predict Clinical Heart Failure Events and Death. Science Transl Med 2013; 5: 215re3, pp1-8. DOI: 10.1126/scitranslmed.3007328