个人简介

Dr. Clifton Bingham is a Professor of Medicine, Director of the Johns Hopkins Arthritis Center, Director of the Center for Patient-Centered Outcomes Research in Rheumatology, Deputy Director for Research in the Division of Rheumatology, and Co-Director of the Rheumatic Diseases Research Core Center. He received his M.D. from Columbia University, where he also completed his Internal Medicine residency. He trained as a Fellow in both Rheumatology and in Allergy and Clinical Immunology at the Brigham and Women’s Hospital. Before coming to Hopkins in 2005, he was on faculty at NYU Hospital for Joint Diseases, where he founded a pioneering clinical and translational research center in rheumatology. He now directs the Johns Hopkins Arthritis Center, a group of 8 rheumatologists, 2 nurses, and a large clinical and research staff that sees more than 4500 patient visits each year, an integrates research with clinical care. His clinical interests are in the care of people living with Rheumatoid Arthritis (RA) and other forms of inflammatory arthritis. Dr. Bingham’s research experience has been diverse, and across the research continuum from bench to bedside. His early work focused on understanding the cytokine regulation of inflammatory mediator generation operative in rheumatologic and allergic diseases. He conducted prior translational research to better understand the role of initiating and amplifying pathways in RA, and has ongoing collaborations with several basic researchers to identify biomarkers for improved patient phenotyping and outcome prediction. Additional multidisciplinary clinical and translational work has focused on the role of periodontal disease and oral bacteria as triggers of RA. In the realm of clinical research, he has served as principal investigator and helped to design and analyze a number of NIH and industry-sponsored clinical trials of multiple agents in early to late phases of development for RA, psoriatic arthritis, and osteoarthritis. He has led several studies of the effects of biological and immunomodulatory therapies on responses to immunizations. A large amount of his current research is focused in the area of patient centered outcomes research, including patient reported outcome development, validation, and integration in clinical care. He serves as a member of the Executive Leadership Committee for the international Outcome Measures in Rheumatology (OMERACT) methodology group. He has authored more than 120 original research articles, reviews, and editorials, and 12 book chapters. He has served as a Co-Editor for the journal of the American College of Rheumatology, Arthritis and Rheumatology, and as a reviewer for a number of rheumatology journals and national and international grant reviews. Columbia University College of Physicians and Surgeons (1990)

研究领域

Arthritis Therapeutics; Clinic Trial outcomes in Arthritis; Oral Health in Arthritis; Patient Reported Outcomes; Rheumatoid Arthritis

Dr. Bingham’s current research is broadly centered on improving the assessment of patients with inflammatory arthritis through more precise disease phenotyping, spanning from biochemical characterization to measuring individual patient level disease experience and contextual factors. This work takes advantage of an integrated clinical and research operation and infrastructure to couple investigation with clinical care. Dr. Bingham directs a number of research projects: (1) Improving the assessment of the patient’s perspective of inflammatory arthritis through development and testing of patient reported outcome measures (e.g. PROMIS); (2) Developing and improving methods to evaluate novel immunomodulatory therapies and treatment strategies; and (3) Evaluating the role of oral inflammation as a disease initiating or amplifying factor in RA;. Additional ongoing collaborative projects are evaluating advanced technologies and molecular diagnostics for imaging RA and OA, mechanisms and mediators of pain in arthritis, and novel bioengineered compounds and stem cells to reduce inflammation and potentially promote joint repair.

近期论文

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Orbai AM, Smith KC, Bartlett SJ, DeLeon E, Bingham CO 3rd. "Stiffness has different meanings, I think, to everyone." Examining stiffness from the perspective of people living with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2014 Nov; 66(11):1662-72. PMID: 24891304. Bartlett SJ, Bykerk VB, Cooksey R, Choy EH, Alten R, Christensen R, Furst DR, Guillemin F, Halls S, Hewlett S, Leong AL, Lyddiatt A, March L, Monte P, Orbai AM, Pohl C, Voshaar MS, Woodworth TG, Bingham CO 3rd. Feasibility and domain validation of RA flare core domain set: A report of the OMERACT Flare working group. J Rheumatol 2015 Feb 15. pii: jrheum.141169. [Epub 2015 Feb 15] PMID: 25684764. Bingham CO 3rd, Alten R, DeWit MP. The Importance of Patient Participation in Measuring Rheumatoid Arthritis Flares. Ann Rheum Dis, 2012;71:7 1107-1109. (Invited Editorial). PMID: 22323439. Boers M, Kirwan JR, Wells G, Beaton D, Gossec L, D'Agostino MA, Conaghan PG, Bingham CO 3rd, Brooks PB, Landewe R, March L, Simon LS, Singh JA, Strand V, Tugwell PT. Developing core outcome measurement sets for clinical trials: OMERACT Filter 2.0. J Clin Epi 2014 Jul;67(7):745-53. PMID: 24582946 McMahan ZH, Bingham CO 3rd. Effects of biological and nonbiological immunomodulatory therapies on the immunogenicity of vaccines in patients with rheumatic diseases. Arthritis Res Ther 2014; 16:506 doi:10.1186/s13075-014-0506-0. PMID: 25587634. Bingham CO 3rd, Rizzo W, Kivitz A, Hassanali A, Upmanyu R, Klearman M. Humoral immune response to vaccines in rheumatoid arthritis patients treated with tocilizumab: results of a randomized controlled trial (VISARA). Ann Rheum Dis 2015; 74:818-822.[Epub 21 Jan 2014]. PMID: 2448345. Winthrop KL, Silverfield J, Racewicz A, Neal J, Lee EB, Hrycaj P, Gomez-Reino J, Soma K, Riese R, Mebus C, Wilkinson B, Hodge J, Fan H, Wang T, Bingham CO 3rd. The effect of tofacitinib on pneumococcal and influenza vaccine responses in rheumatoid arthritis. Ann Rheum Dis 2015 March 20, doi:10.1136/ annrheumdis-2014-207191 [Epub 2015 March 20]. PMID: 5795907. Orbai AM, Bingham CO 3rd. Patient-reported outcomes in rheumatoid arthritis. Curr Rheumatol Rep. 2015 Apr;17(4):501. doi: 10.1007/s11926-015-0501-8. (Invited Review).PMID: 25854489. Bartlett SJ, Haaz S, Mill C, Bernatsky S, Bingham CO 3rd. Yoga in rheumatic diseases. Curr Rheumatol Rep 2013 Dec;15(12):387. (Invited Review). PMID: 24173693. Moonaz SH, Bingham CO 3rd, Wissow L, Bartlett SJ. Yoga in Sedentary Adults with Arthritis: Effects of a Randomized Controlled Pragmatic Trial. J Rheumatol Jul;42(7):1194-202. doi: 10.3899/jrheum.141129. Epub 2015 Apr 1. PMID: 25834206. Timlin H, Bingham CO 3rd. Efficacy and safety implications of molecular constructs of biological agents for rheumatoid arthritis. Expert Opin Biol Ther 2014;14(7):893-904. (Invited Review). PMID: 24720727.