Bigos, Kristin - Johns Hopkins University

个人简介

Dr. Kristin Bigos is an assistant professor of medicine and of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. Her research focuses on brain physiology and brain disorders. Her team currently uses pharmacogenetics and functional neuroimaging to explore novel drug targets and potential therapeutic agents for brain disorders. Dr. Bigos received her B.S. in premedicine from the Pennsylvania State University. She earned her Ph.D. in clinical pharmaceutical sciences from the University of Pittsburg. She completed a post-doctoral fellowship in the clinical brain disorders branch of the Intramural Research Program of the National Institute of Mental Health under Dr. Daniel Weinberger. B.S., Pennsylvania State University (Pennsylvania) (2001) Ph.D., University of Pittsburgh (Pennsylvania) (2007)

研究领域

Dr. Bigos’ research uses pharmacogenetics and functional neuroimaging to identify novel drug targets, test potential therapeutic agents and understand the variability in response to psychiatric medications.

近期论文

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Apud JA, Zhang F, Decot H, Bigos KL, Wienberger DR. "Genetic variation in KCNH2 associated with expression in brain of a unique herg isoform modulates treatment response in patients with schizophrenia." Am J Psychiatry. 2012; 169:725-734. Bigos KL, Bies RR, Pollock BG, Lowy JJ, Zhang F, Weinberger DR. "Genetic variation in CYP3A43 explains racial difference in olanzapine clearance." Molecular Psychiatry. 2011;16:620-625. Bigos KL, Mattay VS, Callicott JH, Straub RE, Vakkalanka R, Kolachana B, Hyde TM, Lipska BK, Kleinman JE, Weinberger DR. "Genetic variation in CACNA1C affects brain circuitries related to mental illness." Arch Gen Psychiatry. 2010;67(9):939-45. Bigos KL, Pollock BG, Aizenstein HJ, Fisher PM, Bies RR, Hariri AR. "Acute 5-HT reuptake blockade poteniates human amygdala reactivity." Neuropsychopharmacology. 2008;33:3221:3225. Bigos KL, Pollock BG, Coley KC, Marder SR, Miller DD, Kirshner MA, Bies RR. "Sex, race, and smoking impact on olanzapine exposure." J Clin Pharmacol. 2008;48(2):157-165.