Ashikaga, Hiroshi - Johns Hopkins University

个人简介

Dr. Ashikaga received an M.D. and a Ph.D. degrees from the University of Tokyo, Japan. He completed his clinical training in Internal Medicine at the University of Tokyo and Beth Israel Medical Center, where he served as a Chief Resident. He received his research training in Biomedical Engineering and Cardiovascular MRI at the University of California, San Diego and the National Institutes of Health. He also completed clinical training in Cardiology and Cardiac Electrophysiology at the Johns Hopkins Hospital. He is currently an Assistant Professor of Medicine and Biomedical Engineering at the Johns Hopkins University School of Medicine. MD, University of Tokyo (1996) University of Tokyo / Internal Medicine (1997) Mount Sinai Beth Israel Medical Center / Internal Medicine (2001)

研究领域

Spiral Reentry; Cardiac Biomechanics; Computational Fluid Dynamics; Information Theory; Synchronization; Computational Neuroscience; Geopolitics

近期论文

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Ashikaga H, Criscione JC, Omens JH, Covell JW, Ingels NB, Jr. Transmural left ventricular mechanics underlying torsional recoil during relaxation. Am J Physiol Heart Circ Physiol 286: H640-H647, 2004 (PMCID: PMC2954110) Ashikaga H, Omens JH, Ingels NB, Jr, Covell JW. Transmural mechanics at left ventricular epicardial pacing site. Am J Physiol Heart Circ Physiol 286: H2401-H2407, 2004 (PMCID: PMC2965026) Ashikaga H, Omens JH, Covell JW. Time-dependent remodeling of transmural architecture underlying abnormal ventricular geometry in chronic volume overload heart failure. Am J Physiol Heart Circ Physiol 287: H1994-H2002, 2004 (PMCID: PMC2842928) Harrington KB, Rodriguez F, Cheng A, Langer F, Ashikaga H, Daughters GT, Criscione JC, Ingels NB, Jr., Miller DC. Direct measurement of transmural laminar architecture in the anterolateral wall of the ovine left ventricle: new implications for wall thickening mechanics. Am J Physiol Heart Circ Physiol 288: H1324-H1330, 2005 Ashikaga H, Covell JW, Omens JH. Diastolic dysfunction in volume overload hypertrophy is associated with abnormal shearing of myolaminar sheets. Am J Physiol Heart Circ Physiol 288: H2603-H2610, 2005 (PMCID: PMC2822838) Ashikaga H, Mickelsen SR, Ennis DB, Rodriguez I, Kellman P, Wen H, McVeigh ER. Electromechanical analysis of infarct border zone in chronic myocardial infarction. Am J Physiol Heart Circ Physiol 289: H1099-H1105, 2005 (PMCID: PMC2396317) Mickelsen SR, Ashikaga H, Raval A, DeSilva R, McVeigh ER, Kusumoto FA. Transvenous access to the pericardial space: an approach to epicardial lead implantation for cardiac resynchronization therapy. Pacing Clin Electrophysiol 28: 1018-24, 2005 Moreau-Villger V, Delingette H, Sermesant M, Ashikaga H, McVeigh ER, Ayache N. Building maps of local apparent conductivity of the epicardium with a 2-D electrophysiological model of the heart. IEEE Trans Biomed Eng 53: 1457-66, 2006 Dickfeld T, Kato R, Zviman MM, Nazarian S, Dong J, Ashikaga H, Lardo AC, Berger RD, Calkins H, Halperin HR. Characterization of acute and subacute radiofrequencey ablation lesions with nonenhanced magnetic resonance imaging. Heart Rhythm 4: 208-14, 2007 Ashikaga H, Coppola BA, Hopenfeld B, Leifer ES, McVeigh ER, Omens JH. Transmural dispersion of myofiber mechanics: implications for electrical heterogeneity in vivo. J Am Coll Cardiol 49: 909-16, 2007 (PMCID: PMC2572715) Ciaccio EJ, Ashikaga H, Kaba RA, Cervantes D, Hopenfeld B, Wit AL, Peters NS, McVeigh E, Garan H, Coromilas J. Model of reentrant ventricular tachycardia based on infarct border zone geometry predicts reentrant circuit features as determined by activation mapping. Heart Rhythm 4: 1034-45, 2007 (PMCID: PMC2626544) Hopenfeld B, Ashikaga H, McVeigh ER. Geodesic based registration of sensor data and anatomical surface image data. Ann Biomed Eng 35: 1771-81, 2007 (PMCID: PMC2842929) Ashikaga H, Sasano T, Dong J, Zviman MM, Evers R, Hopenfeld B, Castro V, Helm RH, Dickfeld T, Nazarian S, Donahue JK, Berger RD, Calkins H, Abraham MR, Marbn E, Lardo AC, McVeigh ER, Halperin HR. Magnetic resonance-based anatomical analysis of scar-related ventricular tachycardia: implications for catheter ablation. Circ Res 101: 939-47, 2007 (PMCID: PMC2842927) Jbsis PD, Ashikaga H, Wen H, Rothstein EC, Horvath KA, McVeigh ER, Balaban RS. Visceral pericardium: macromolecular structure and contribution to passive mechanical properties of the left ventricle. Am J Physiol Heart Circ Physiol 293: H3379-H3387, 2007 (PMCID: PMC2878718) Ashikaga H, Coppola BA, Yamazaki KG, Villarreal FJ, Omens JH, Covell JW. Changes in regional myocardial volume during the cardiac cycle: implications for transmural blood flow and cardiac structure. Am J Physiol Heart Circ Physiol 295: H610-H618, 2008 (PMCID: PMC2519196) Sasano T, Abraham MR, Chang KC, Ashikaga H, Mills KJ, Holt DP, Hilton J, Nekolla SG, Dong J, Lardo AC, Helperin H, Dannals RF, Marbn E, Bengel FM. Abnormal sympathetic innervation of viable myocardium and the substrate of ventricular tachycardia after myocardial infarction. J Am Coll Cardiol 51: 2266-75, 2008 Nazarian S, Kolandaivelu A, Zviman MM, Meininger GR, Kato R, Susil RC, Roguin R, Dickfeld TL, Ashikaga H, Calkins H, Berger RD, Blumke DA, Lardo AC, Halperin HR. Feasibility of real-time magnetic resonance imaging for catheter guidance in electrophysiology studies. Circulation　118: 223-9, 2008 (PMCID: PMC2826501) Ashikaga H, van der Spoel TIG, Coppola BA, Omens JH. Transmural myocardial mechanics during isovolumic contraction. JACC Cardiovasc Imaging 2: 202-211, 2009 (PMCID: PMC2821599) Hopenfeld B and Ashikaga H. Origin of electrocardiographic U wave: Effects of M cells and dynamic gap junction coupling. Ann Biomed Eng 38: 1060-70, 2010 (PMCID: PMC2842929) Ashikaga H, Leclercq C, Wang J, Kass DA, McVeigh ER. Hemodynamic improvement in cardiac resynchronization does not require improvement in left ventricular rotation mechanics: three-dimensional tagged MRI analysis. Circ Cardiovasc Img 3: 456-63, 2010 (PMCID: PMC2965024) Estner HL, Zviman MM, Herzka D, Miller F, Castro V, Nazarian S, Ashikaga H, Dori Y, Berger RD, Calkins H, Lardo AC, Halperin HR. The critical isthmus sites of ischemic ventricular tachycardia are in zones of tissue heterogeneity, visualized by magnetic resonance imaging. Heart Rhythm 8: 1942-9, 2011 Ashikaga H, Omens JH. In vivo validation of longitudinal-circumferential area change ratio to estimate myofiber shortening in the heart. IEEE Trans Biomed Eng 59: 1391-7, 2012