Anderson, Mark - Johns Hopkins University

个人简介

Mark Anderson is the William Osler Professor of Medicine, the director of the Department of Medicine in the Johns Hopkins University School of Medicine and physician-in-chief of The Johns Hopkins Hospital. A 1981 honors graduate in biology from Macalester College in St. Paul, Minnesota, Dr. Anderson received his Ph.D. in physiology and his M.D. from the University of Minnesota. He then completed his internal medicine residency and fellowships in cardiology and clinical cardiac electrophysiology at Stanford before joining the faculty at Vanderbilt in 1996. In October 2005, he moved to the University of Iowa Carver College of Medicine and in 2009 was named chairman and department executive officer of internal medicine. In 2012, he became director of the Cardiovascular Research Center. An outstanding scientist, teacher and caregiver, Dr. Anderson has focused his research on the role of the protein CaMKII (Ca2+/calmodulin dependent kinase II) in heart failure and cardiac arrhythmias, a cause of sudden cardiac death. He has published more than 160 peer-reviewed journal articles, book chapters and book reviews, and has been an invited speaker throughout the United States and in more than a dozen nations. MD, University of Minnesota Medical School (1989)

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Lai M, Wu Y, Gao Z, Anderson ME, Dalziel J, Meredith A. BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo. Am J Physiol Heart and Circulatory Physiol. 2014. In press Chakraborty A, Pasek DA, Huang TQ, Gomez SAC, Yamaguchi N, Anderson ME, Meissner GW. Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptor. PLoS One 2014 Aug 5; 9(8):e104338. [PMID: 25093823] Jaffer O, Zabner J, Grumbach IM, Anderson ME. Mitochondiral-targeted antioxidant therapy decreases TGFb Mediated Collagen production in a murine asthma model." Am J Respir Cell Mol Biol 2014 Jul 2. [PMID: 24988374] [Epub ahead of print] Hall DD, Wu Y, Domann FE, Spitz DR, Anderson ME. Mitochondrial Calcium Uniporter Activity is Dispensable for MDA-MB-231 Breast Carcinoma Cell Survival. PLoS One 2014 May 6; 9(5):e96866. PMCID: PMC4011874. Zhang C, Chen B, Guo A, Zhu Y, Miller J, Gao S, Yuan C, Kutschke W, Zimmerman K, Weiss RM, Wehrens XH, Hong J, Johnson F, Santana L, Anderson ME, Song LS. Microtuble-mediated defects in junctophilin-2 trafficking contribute to myocyte T-tubule remodeling and Ca2+ handling dysfunction in heart failure. Circulation 2014 Apr 29;129(17): 1742-50. PMCID: PMC4006305 Hund, TJ, Snyder JS, Xiangqiong W, Glynn P, Koval OM, Onal B, Leymaster ND, Unudurthi SD, Curran J, Camardo C, Wright PJ, Binkley PF, Anderson ME, Mohler PJ. βIV-spectrin regulates TREK-1 membrane targeting in heart. Cardiovas Res 2014 Apr 1; 102(1): 166-175. PMCID: PMC3958619. Zhu LJ, Klutho PJ, Scott JA, Litao X, Luczak ED, Dibbern ME, Prasad AM, Jaffer O, Venema AN, Ngyuen EK, Xiaoqun G, Anderson ME, Grumbach IM. Oxidative activation of the Ca2+/calmodulin-dependent kinase II. Vascular Pharmacology 2014 Feb; 60(2):75-83. PMCID: PMC3955051. Ho HT, Liu B, Snyder JS, Lou Q, Brundage EA, Velez-Cortes F, Wang H, Ziolo MT, Anderson ME, Sen CK, Wehrens XH, Fedorov VV, Biesiadecki BJ, Hund TJ, Györke S. Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides. Cardiovas Res 2014 Jan 1; 101(1):165-74. PMCID: PMC3868350. Zhu Z, Sierra A, Burnett CM, Chen B, Subbontina E, Koganti SR, Gao Z, Wu Y, Anderson ME, Song LS, Goldhamer DJ, Coetzee WA, Hodgson-Zingman DM, Zingman LV. Sarcolemmal ATP-sensitive potassium channels modulate skeletal muscle function under low-intensity workloads. J Gen Physiol 2014 Jan; 143(1): 119-34. PMCID: PMC3874572. Kline CF, Wright PJ, Koval OM, Zmuda EJ, Johnson BL, Anderson ME, Hai T, Hund TJ, Mohler PJ. βIV- spectrin and CaMKII facilitate Kir6.2 regulation in pancreatic beta cells. Proc Natl Acad Sci. 2013 Oct 22;110(43):17576-81 PMCID: PMC3808601.