Ambinder, Richard F - Johns Hopkins University

个人简介

Richard F. Ambinder, M.D., Ph.D., currently serves as the James B. Murphy Professor of Oncology and the Director of the Division of Hematologic Malignancies at the Johns Hopkins Kimmel Cancer Center. He is program co-leader of the Hematologic Malignancies and Bone Marrow Transplantation Program and leads the AIDS Malignancy Consortium (AMC) site at Johns Hopkins and the AMC Translational Sciences Working Group nationally. Dr. Ambinder graduated from Harvard College with a Bachelor’s degree in biochemistry, after which he received his medical degree from the Johns Hopkins University School of Medicine before completing his residency at the Johns Hopkins Hospital. He also earned his Ph.D. in pharmacology from the Johns Hopkins University, and completed his oncology fellowship at Johns Hopkins. Within the clinic, Dr. Ambinder is active in the treatment of lymphoma and Kaposi’s sarcoma. Dr. Ambinder’s research is focused on exploring opportunities to prevent or treat cancer with viral infections. Virus-associated tumors are among the most common malignancies in certain populations and regions. For instance, Burkitt's lymphoma (EBV) and Kaposi's sarcoma (KSHV) are common in equatorial Africa, nasopharyngeal carcinoma (EBV) is common in southern Chinese populations or those with southern Chinese origins, and immunoblastic lymphomas (EBV) are common in immunocompromised patients (organ transplant recipients, AIDS patients, etc). Thus, Dr. Ambinder’s new approaches to prevention, diagnosis, and treatment stand to have a direct impact on the lives of cancer patients around the globe. Additionally, the study of how viruses can impact these tumors is important in creating model systems for the development of new approaches to cancer care. Currently, many immunotherapies target unidentified antigens, making the measurement of relevant immune responses problematic at best. However, in EBV-associated tumors the antigens are well defined, thus allowing the Ambinder lab to define the epitope-specific cellular immune responses. As a result of this breakthrough, interventions designed to alter immune response —whether they be vaccine based interventions, adoptive immunotherapy interventions, or pharmacologic interventions — may all be assessed in terms of relevant surrogate markers. Much in the same way the treatment of Hodgkin's lymphoma with radiotherapy and chemotherapy paved the way for the modern approach to cancer treatment more broadly, the treatment of EBV-associated tumors (including Hodgkin's lymphoma) may pave the way to the more generalized use of these modalities to treat a myriad of cancer types. MD, Johns Hopkins University School of Medicine (1979)

研究领域

Lymphoma; Kaposi's Sarcoma; Epstein-Barr Virus and Cancer; AIDS Associated Cancers; Lymphoma biology; Antitumor therapy; Antiviral therapy; Virology in human cancer

近期论文

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Cannon JS, Ciufo D, Hawkins AL, Griffin CA, Borowitz MJ, Hayward GS and Ambinder RF. A New Primary Effusion Lymphoma - Derived Cell Line Yields Highly Infectious Kaposis Sarcoma Herpesvirus Supernatant. J Virol, 74:10187-10193, 2000. (PMID: 11024147) Yang J, Tao Q, Flinn IW, Murray PG, Post LE, Ma H, Piantadosi S, Caligiuri MA, Ambinder RF. Characterization of Epstein Barr Virus-infected B Cells in Patients with Posttransplantation Lymphoproliferative Disease: Disappearance after Rituximab Therapy does not Predict Clinical Response. Blood, 96:4055-4063, 2000. (PMID: 11110673) Flinn IW, ODonnell PV, Goodrich A, Vogelsang G, Abrams R, Noga S, Marcellus D, Borowitz M, Jones R, Ambinder RF. Immunotherapy with Rituximab during Peripheral Blood Stem Cell Transplantation for Non-Hodgkins Lymphoma. Biology of Blood and Marrow Transplantation, 6:628-632, 2000. (PMID: 11128813) Moore SM, Cannon JS, Tanhehco YC, Hamzeh FM, Ambinder RF. Induction of Epstein-Barr Virus Kinases to Sensitize Tumor Cells to Nucleoside Analogues. Antimicrob Agents Chemother. 45:2082-2091, 2001. (PMID: 11408227) Glaser SL, Clarke CA, Gulley ML, Craig FE, DiGiuseppe JA, Dorfman RF, Mann RB, Ambinder RF. Population-Based Patterns of Human Immunodeficiency Virus-Related Hodgkin Lymphoma in the Greater San Francisco Bay Area. Cancer, 98:300-309, 2003. (PMID: 12872349) Chan AT, Tao Q, Robertson KD, Flinn IW, Mann RB, Klencke B, Kwan WH, Leung TW, Johnson PJ, Ambinder RF. Azacitidine Induces Demethylation of the Epstein-Barr Virus Genome in Tumors in Patients. J Clin Oncol: 22: 1373-81, 2004. (PMID: 15007085) Glaser SL, Keegan THM, Clarke CA, Trinh M, Dorfman RF, Mann RB, DiGiuseppe JA, Ambinder RF. Exposure to Childhood Infections and Risk of Epstein-Barr Virus-Defined Hodgkins Lymphoma in Women. Int J Cancer 115 : 599-605, 2005. (PMID: 15700307) Keegan TH, Glaser SL, Clarke CA, Gulley ML, Craig FE, Digiuseppe JA, Dorfman RF, Mann RB, Ambinder RF. Epstein Barr Virus as a Marker of Survival after Hodgkin's Lymphoma: a Population Based Study. J Clin Oncol. 23: 7604 13, 2005. (PMID: 16186595) Keegan TH, Glaser SL, Clarke CA, Dorfman RF, Mann RB, DiGiuseppe JA, Chang ET, Ambinder RF. Body Size, Physical Activity, and Risk of Hodgkin's Lymphoma in Women. Cancer Epidemiology Biomarkers & Prevention 15:1095-1101, 2006. (PMID: 16775165) Fu D X, Tanhehco YC, Chen J, Foss CA, Fox JJ, Lemas V, Chong JM, Ambinder R F, Pomper MG. Virus-Associated Tumor Imaging by Induction of Viral Gene Expression. Clin Cancer Res. 13: 1453-8, 2007. (PMID: 17332288) Glaser SL, Gully ML, Clarke CA, Keegan TH, Chang ET, Shema SJ, Craig FE, DiGiuseppe JA, Dorfman RF, Mann RB, Culver HA, Coszen W, Ambinder, RF. Racial/Ethnic Variation in EBV-Positive Classical Hodgkin Lymphoma in California Populations. Int J Cancer. 123:1499-1507, 2008. (PMID: 18646185) Fu D, Tanhehco Y, Chen J, Foss CA, Fos JF, Chong J, Hobbs RF, Fukayama M, Sgouros G, Kowalski J, Pomper MG, Ambinder RF. Bortezomib-Induced Enzyme-Targeted Radiotherapy in Herpesvirus-Associated Tumors. Nat Med. 14:1118-22, 2008. (PMID: 18776891) Jones RJ, Gocke CD, Kasamon YL, Miller CB, Perkins B, Barber JP, Vala MS, Gerber JM, Gellert LL, Siedner M, Lemas MV, Brennan S, Ambinder RF, Matsui W. Circulating Clonotypic B Cells in Classical Hodgkin's Lymphoma. Blood .113:5920-6, 2009. (PMID: 19188663) Lin L, Lee JY, Kaplan LD, Dezube BJ, Noy A, Krown SE, Levine AM, Yu Y, Hayward GS, Ambinder RF. Effects of Chemotherapy in AIDS-Associated Non-Hodgkins Lymphoma on KSHV DNA in Blood. J Clin Oncol. 27: 2496-502, 2009. (PMID: 1934954) Aksentijevich, I.; Jones, R.J.; Ambinder, R.F.; Garrett-Mayer, E.; Flinn, I.W. Clinical outcome following autologous and allogeneic blood and marrow transplantation for relapsed diffuse large-cell non-Hodgkin's lymphoma. Biol Blood Marrow Transplant. 2006 Sep;12(9):965-972. Ambinder, R.F. Epstein-Barr virus and HIV. In: Tselis, A.; Jenson, H.B., editors, Epstein-Barr Virus. New York, NY: Taylor and Francis Group; 2006. Huff, C.A.; Fuchs, E.J.; Smith, B.D.; Blackford, A.; Garrett-Mayer, E.; Brodsky, R.A.; Flinn, I.W.; Ambinder, R.F.; Borrello, I.M.; Matsui, W.H.; Vogelsang, G.B.; Griffin, C.A.; Luznik, L.; Jones, R.J. Graft-versus-host reactions and the effectiveness of donor lymphocyte infusions. Biol Blood Marrow Transplant. 2006 Apr;12(4):414-421. Keegan, T.H.; Glaser, S.L.; Clarke, C.A.; Dorfman, R.F.; Mann, R.B.; DiGiuseppe, J.A.; Chang, E.T.; Ambinder, R.F. Body size, physical activity, and risk of Hodgkin's lymphoma in women. Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1095-1101. Krown, S.E.; Lee, J.Y.; Lin, L.; Fischl, M.A.; Ambinder, R.; Von Roenn, J.H. Interferon-alpha2b with protease inhibitor-based antiretroviral therapy in patients with AIDS-associated Kaposi sarcoma: an AIDS malignancy consortium phase I trial. J Acquir Immune Defic Syndr. 2006 Feb 1;41(2):149-153. Ambinder, R.F. Epstein-barr virus and hodgkin lymphoma. Hematology / the Education Program of the American Society of Hematology American Society of Hematology. 2007;2007:204-209. Berdeja, J.G.; Hess, A.; Lucas, D.M.; O'Donnell, P.; Ambinder, R.F.; Diehl, L.F.; Carter-Brookins, D.; Newton, S.; Flinn, I.W. Systemic interleukin-2 and adoptive transfer of lymphokine-activated killer cells improves antibody-dependent cellular cytotoxicity in patients with relapsed B-cell lymphoma treated with rituximab. Clin Cancer Res. 2007 Apr 15;13(8):2392-2399. Bolanos-Meade, J.; Garrett-Mayer, E.; Luznik, L.; Anders, V.; Webb, J.; Fuchs, E.J.; Huff, C.A.; Matsui, W.; Borrello, I.M.; Brodsky, R.; Kasamon, Y.L.; Swinnen, L.J.; Flinn, I.W.; Ambinder, R.F.; Jones, R.J.; Hess, A.D.; Vogelsang, G.B. Induction of autologous graft-versus-host disease: results of a randomized prospective clinical trial in patients with poor risk lymphoma. Biol Blood Marrow Transplant. 2007 Oct;13(10):1185-1191. Epeldegui, M.; Hung, Y.P.; McQuay, A.; Ambinder, R.F.; Martinez-Maza, O. Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations. Mol Immunol. 2007 Feb;44(5):934-942. Fu, D.X.; Tanhehco, Y.C.; Chen, J.; Foss, C.A.; Fox, J.J.; Lemas, V.; Chong, J.M.; Ambinder, R.F.; Pomper, M.G. Virus-associated tumor imaging by induction of viral gene expression. Clin Cancer Res. 2007 Mar 1;13(5):1453-1458. Seng, T.J.; Low, J.S.; Li, H.; Cui, Y.; Goh, H.K.; Wong, M.L.; Srivastava, G.; Sidransky, D.; Califano, J.; Steenbergen, R.D.; Rha, S.Y.; Tan, J.; Hsieh, W.S.; Ambinder, R.F.; Lin, X.; Chan, A.T.; Tao, Q. The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation. Oncogene. 2007 Feb 8;26(6):934-944.