Thakor, Nitish V. - Johns Hopkins University - Department of Biomedical Engineering

个人简介

B.Tech., Electrical Engineering, Indian Institute of Technology, 1974 M.S., Biomedical Engineering, University of Wisconsin, Madison; 1978 Ph.D., Electrical and Computer Engineering, 1981

研究领域

“Nano and Micro” Project: We are developing novel microfabricated sensors and devices for neuroscience research. The first example is the development of microelectromechanical (MEMS) techniques that allow us to grown neurons and neural networks on a chip (“Neuro Chip.”). In chip we can study basic neuronal functions such as axonal injury, myelination, neuromuscular junction formation. Basic studies then translate into ex vivo and in vivo study of nerve and spinal cord injury. “Neural Devices” Project: A number of very large scale integrated circuit (VLSIC) chips are under development. One is a VLSI chip to interface neural microsensors to amplifiers and telemetry. The potentiostat chip is capable of measuring pA level currents for neurotransmitter measurmeents. A sub-microvolt amplifier chip records multichannel EEG and neural activity. These are then coupled to wireless data transfer and power harvesting. These neural devices are useful for recording neural activity in rodents and eventually in man for building brain machine interfaces. “Neuro Imaging” Project: Optical methods, such as laser speckle imaging and photo-acoustic imaging provide a window into the brain, by shining coherent laser light and imaging speckle contrast or acoustic signature. Using these methods we image the microvessels in the brain, as well as the blood flow and oxygenation. A novel microscope suitable for imaging from awake, behaving animals is under development. Laser speckle imaging used to image tumor related angiogenesis (enhance vasculature) in brain as well as blood flow and oxygenation changes in a stroke model. Retinal imaging technology is under development by a startup spun off out of our lab. “Brain Monitoring” from “Bench to Bedside”: We have a long term interest in studying the basic mechanisms of brain injury, developing mathematical models of neurons and neural networks, and signal processing methods for analyzing brain rhythms. On the basic research side, we study what happens to brain when heart stops, using neural recording and signatures such as EEG and evoked potential. On the clinical side, we are developing diagnostic monitors for brain injury detection in the operating room and neurological intensive care. Through a “startup”, we are doing technology transfer to take ideas from “bench to bedside.” Our instruments are now presently approaching clinical evaluation (e.g. we monitored patients undergoing high risk brain surgery). “Brain Machine Interface” Project: This is an exciting new field where we record brain activity, build quantitative data analysis methods and then use the methods to control robotic and prosthetic arms (for future amputee applications). Noninvasive methods are based on EEG while invasive methods are based on Electrocorticogram signals and direct neural signals recorded from population of neurons. Our brain machine algorithms decode dexterous hand and finger movements, resulting in a better understanding of brain organization, and applications to building neuroprosthetic devices. “Prosthesis: from Research to Practice”: Our goal here is simple — to build dexterous prosthetic arm, here and now and make them available to amputees. Our collaboration, with a technology spinoff or startup, is to develop components of the prosthesis, including electrode, battery, electronics, and controller for myoelectric (muscle signal) pattern recognition. Hundreds of amputees have presently benefited from this research and development partnership of students, engineers, prosthetists, clinicians and entrepreneurs.

近期论文

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Osborn L, Kaliki R, Suares AB, Thakor NV, Neuromimetic Event-Based Detection for Closed-Loop Tactile Feedback Control of Upper Limb Prostheses, IEEE Transactions on Haptics, Vol. 9, 2016 Full Text Hotson G, Smith RJ, Rouse AG, Schieber MH, Thakor NV, Wester BA, High Precision Neural Decoding of Complex Movement Trajectories Using Recursive Bayesian Estimation With Dynamic Movement Primitives, IEEE Robotics and Automation Letters, Vol. 1, 2016 Full Text Yu H, Senarathna J, Tyler BM, Thakor NV, Pathak AP, Miniaturized optical neuroimaging in unrestrained animals, NeuroImage, 2015 Full Text Orchard G, Etienne-Cummings R, Thakor NV, Benosman R, H-First: A temporal approach to object recognition, IEEE Trans. Pattern Recog. Machine Intell., 2015 Full Text Ma J, Thakor NV, and Fumitoshi M, Hand and wrist movement control of myoelectric prosthesis based on synergy, IEEE Trans. Human Machine System, 2015 Full Text Yuan Y, Wang Z, Cai P, Liu J, Liao L-D, Hong M, Chen X, Thakor NV, Bin L, Conjugated polymer and drug co-encapsulated nanoparticles for photothermal combined chemotherapy with two-photon regulated fast drug release, Nanoscale, 2015 Full Text Nag S, Sikdar S, Thakor NV, Rao V, Sharma D, Sensing of stimulus artifact suppressed signals from electrode interfaces, IEEE Sensors, 2015 Full Text Kim Y-H, Thakor NV, Kim H-N, Neuron Selection Based on Deflection Coefficient Maximization for the Neural Decoding of Dexterous Finger Movements, IEEE Trans. Neural Systems Rehab. Eng., 2014 Full Text Hotson G, Fifer MS, Acharya S, Benz HL, Anderson WS, Thakor NV, Crone NE, Coarse Electrocorticographic Decoding of Ipsilateral Reach in Patients with Brain Lesions, PLoS ONE, 2014 Full Text VLSI Yan Y, Ng LF, Gruber J, Bettiol AA, Thakor NV, A continuous-flow C. elegans sorting system with integrated optical fiber detection and laminar flow switching, Lab Chip, 2014 Full Text Shang Y, Liao Lun-De, Thakor NV and Tan MC, Rare earth doped particles as dual-modality contrast agent for minimally invasive luminescence and dual wavelength photo-acoustic imaging, Vol. 4: 6562, 2014 Full Text Geng J*, Liao LD*, Qin W, Tang B, Thakor NV, Bin L, An effective strategy to improve photoacoustic contrast of a fluorophore through introducing molecular rotation, J.Nanosci. Nanotech., 2014 Full Text Liu J, Geng J, Liao L-D,�Thakor�NV, Gao X, Bin L, Conjugated polymer Nanoparticles for Photoacoustic Vascular Imaging, Polymer Chem., Vol.5, pp. 2854-2862, 2014 Full Text Siddique R, Thakor NV, Investigation of Nerve Injury through Microfluidic Devices, J. Royal Soc. Interface, 2014 Full Text Liao L-D, Bandla A, Ling JM, Liu Y-H, Kuo L-W, Chen Y-Y, King NKK, Lai Y-H, Lin Y-R, and Thakor NV, Improving neurovascular outcomes with bilateral forepaw stimulation in a rat photothrombotic ischemic stroke model, 2014 Full Text Sun Y, Lim J, Meng J, Kenneth K, Thakor NV, Bezerianos A, Discriminative Analysis of Brain Functional Connectivity Patterns for Mental Fatigue Classification, Annals Biomed. Eng, 2014 Full Text Sheng Y, Liao L-D, Thakor NV, MC Tan, Nanoparticles for molecular imaging, J. Biomed. Nanotech., Vol. 10, pp. 2642-2676, 2014 Full Text Xiang Z, Yen Y-S, Xue N, Sun T, Tsang WM, Zhang S, Liao L-D, Thakor NV Lee C, Ultra-thin flexible polyimide neural probe embedded in a dissolvable maltose-coated microneedle, J. Micromech. Microeng., vol. 24, pp. 065015, 2014 Full Text Bazley FA, Maybhate A, Seng TC, Thakor NV, Kerr CL, All AH, Enhancement of bilateral cortical somatosensory evoked potentials to intact forelimb stimulation following thoracic contusion spinal cord injury in rats, IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2014 Full Text Kong KV, Liao L-D, Lam Z, Thakor NV, Leong WK, Olivo M, Organometallic carbonyl clusters: a new class of contrast agents for photoacoustic cerebral vascular imaging, Chemical Communications, Vol. 50, pp. 2601-2603, 2014 Full Text Tsytsarev V, Liao L-D, Kong KV, Liu Y-H, Erzurumiu RE, Olivio M, and Thakor NV, Recent progress in voltage-sensitive dye imaging for neuroscience, J. Nanosci. Nanotech, Vol. 14, pp. 4733-4744, 2014 Full Text Powell MA, Kaliki RR, Thakor NV, User Training for Pattern Recognition-Based Myoelectric Prostheses: Improving Phantom Limb Movement Consistency and Distinguishability, IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol.22, No.3, pp.522-532, 2014 Full Text Li N, van Zijl P, Thakor NV, Pelled G, Study of the Spatial Correlation Between Neuronal Activity and BOLD fMRI Responses Evoked by Sensory and Channelrhodopsin-2 Stimulation in the Rat Somatosensory Cortex, J. Mol. Neurosci., 2014 Full Text Chen C, Maybhate A, Israel D, Thakor NV, Jia X, Assessing thalamocortical functional connectivity with Granger causality, IEEE Trans Neural Syst Rehabil Eng, Vol. 21(5), pp. 725-733, 2013 Full Text Liao L-D, Tsytsarev V, Delgado-Mart�nez I, Li M-L, Erzurumlu R, Lin Y-R, Vipin A, Lai H-Y, Chen Y-Y, Thakor NV, Neurovascular coupling: in vivo optical techniques for functional brain imaging, BioMed Eng Online, 12:38, 2013 Full Text