Popel, Aleksander S - Johns Hopkins University - Department of Biomedical Engineering

个人简介

M.S. in Mechanics and PhD. in Biofluidmechnics, Moscow University

研究领域

The overarching goal of the Systems Biology Laboratory is to apply modern methods of biomedical engineering to better understand the mechanisms of cancer and to significantly advance treatments for this devastating disease. Cancer cells invade into healthy tissues and co-opt these tissues into promoting tumor growth and metastasis. They use multitude of ways to evade therapeutics by adapting to drugs making them ineffective. To control and conquer the disease, the applications of modern quantitative methods are absolutely necessary; our laboratory is at the cutting edge of the cancer systems biology research. The research in the laboratory is broad and uses a combination of experimental and computational approaches. We investigate cancer at different levels from genes to proteins to tumor, and eventually to the whole body. We look into the ways the factors that stimulate tumor growth (eg growth factors) signal to the interior of the cell, and how cancer cells communicate with their neighbors such as immune cells and vascular cells. We develop and test novel drugs to treat different types of cancer. Our research focuses on the following areas: Fundamental studies of cancer biology to better understand how different cells interact to cause cancer metastasis Identification of novel molecular drug targets for different types of cancer Drug discovery including therapeutic peptide agents to inhibit tumor growth and metastasis Immuno-oncology aimed at turning patient’s immune system to targeting cancer cells

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Chu LH, Vijay CG, Annex BH, Bader JS, Popel AS. PADPIN: Protein-Protein Interaction Networks of Angiogenesis, Arteriogenesis, and Inflammation in Peripheral Arterial Disease. Physiol Genomics. (Accepted) Lee E, Pandey NB, Popel AS. Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment. Expert Rev Mol Med. 2015 Jan 30;17:e3. [Abstract] Lee E, Lee SJ, Koskimaki JE, Han Z, Pandey NB, Popel AS. Inhibition of breast cancer growth and metastasis by a biomimetic peptide. Sci Rep. 2014 Nov 20;4:7139. [Abstract] Kim E, Lee E, Plummer C, Gil S, Popel AS, Pathak AP. Vasculature-specific MRI reveals differential anti-angiogenic effects of a biomimetic peptide in an orthotopic breast cancer model. Angiogenesis. 2015 Apr;18(2):125-36.[Abstract] Rosca EV, Penet MF, Mori N, Koskimaki JE, Lee E, Pandey NB, Bhujwalla ZM, Popel AS. A biomimetic collagen derived peptide exhibits anti-angiogenic activity in triple negative breast cancer.PLoS One. 2014 Nov 10;9(11):e111901. [Abstract] Chu LH, Lee E, Bader JS, Popel AS. Angiogenesis interactome and time course microarray data reveal the distinct activation patterns in endothelial cells. PLoS One. 2014 Oct 16;9(10):e110871. [Abstract] Finley SD, Chu LH, Popel AS. Computational systems biology approaches to anti-angiogenic cancer therapeutics. Drug Discov Today. 2014 Oct 5. pii: S1359-6446(14)00395-X. Review. [Abstract] Norton KA, Han Z, Popel AS, Pandey NB. Antiangiogenic cancer drug sunitinib exhibits unexpected proangiogenic effects on endothelial cells. Onco Targets Ther. 2014 Sep 9;7:1571-82. [Abstract] Norton KA, Popel AS. An agent-based model of cancer stem cell initiated avascular tumour growth and metastasis: the effect of seeding frequency and location. J R Soc Interface. 2014 Nov 6;11(100):20140640. [Abstract] Lee E, Fertig EJ, Jin K, Sukumar S, Pandey NB, Popel AS. Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. Nat Commun. 2014 Sep 2;5:4715. [Abstract] Lee E, Pandey NB, Popel AS. Lymphatic endothelial cells support tumor growth in breast cancer. Sci Rep. 2014 Jul 28;4:5853.[Abstract] Imoukhuede PI, Popel AS. Quantitative fluorescent profiling of VEGFRs reveals tumor cell and endothelial cell heterogeneity in breast cancer xenografts. Cancer Med. 2014 Apr;3(2):225-44. [Abstract] Stamatelos SK, Kim E, Pathak AP, Popel AS. A bioimage informatics based reconstruction of breast tumor microvasculature with computational blood flow predictions. Microvasc Res. 2014 Jan;91:8-21. [Abstract] Vempati P, Popel AS, Mac Gabhann F. Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning. Cytokine Growth Factor Rev. 2014 Feb;25(1):1-19. [Abstract] Logsdon EA, Finley SD, Popel AS, Mac Gabhann F. A systems biology view of blood vessel growth and remodelling. J Cell Mol Med. 2014 Aug;18(8):1491-508. [Abstract] Tan WH, Popel AS, Mac Gabhann F. Computational model of VEGFR2 pathway to ERK activation and modulation through receptor trafficking. Cell Signal. 2013 Dec;25(12):2496-510. [Abstract] Lee E, Pandey NB, Popel AS. Pre-treatment of mice with tumor-conditioned media accelerates metastasis to lymph nodes and lungs: a new spontaneous breast cancer metastasis model. Clin Exp Metastasis. 2013 Aug 21. [Abstract] Finley SD, Dhar M, Popel AS. Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing mice. Front Oncol. 2013 Jul 30;3:196. [Abstract] Shmueli RB, Ohnaka M, Miki A, Pandey NB, Lima e Silva R, Koskimaki JE, Kim J, Popel AS, Campochiaro PA, Green JJ. Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide. Biomaterials. 2013 Oct;34(30):7544-51. [Abstract] Tan WH, Popel AS, Mac Gabhann F. Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation. PLoS One. 2013 Jun 21;8(6):e67438. [Abstract] Lee E, Koskimaki JE, Pandey NB, Popel AS. Inhibition of lymphangiogenesis and angiogenesis in breast tumor xenografts and lymph nodes by a peptide derived from transmembrane protein 45A. Neoplasia. 2013 Feb;15(2):112-24. [Abstract] Imoukhuede PI, Dokun AO, Annex BH, Popel AS. Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia. Am J Physiol Heart Circ Physiol. 2013 Apr 15;304(8):H1085-93. [Abstract] Koskimaki JE, Lee E, Chen W, Rivera CG, Rosca EV, Pandey NB, Popel AS. Synergy between a collagen IV mimetic peptide and a somatotropin-domain derived peptide as angiogenesis and lymphangiogenesis inhibitors. Angiogenesis. 2013 Jan;16(1):159-70. [Abstract] Rivera CG, Chu LH, Popel AS, Bader JS. Chapter 9, Systems Biology in Cancer Research and Drug Discovery, in Applications of Network Bioinformatics for Cancer Angiogenesis, 2012, Part 2, 229-244. [Abstract] Chu LH, Rivera CG, Popel AS, Bader JS. Constructing the angiome: a global angiogenesis protein interaction network. Physiol Genomics. 2012 Oct 2;44(19):915-24. [Abstract]