All, Angelo H - Johns Hopkins University - Department of Biomedical Engineering

个人简介

MBA, Medical Services Management, Johns Hopkins University, 2008 MD, Medicine, University of Verona, Italy, 1996

研究领域

The focus of my research is on peripheral and central nervous system injury, repair, and regeneration. My laboratory has pioneered the monitoring and quantitative analysis of multi-channel somatosensory and motor evoked potentials, as well as action potential and compound evoked potential in order to assess the electrical integrity at various stages, both pre and post central and peripheral nerves injury. In addition, we use different imaging techniques to monitor anatomical changes in injured nerves, brain, and spinal cord architectures at various time points. These images allow us to identify spared fibers and track the extent of secondary injury, and determine the therapeutic benefit of the therapy. My translational research projects involves acute hypothermia treatment as well as chronic stem cell replacement therapy using oligodendrocyte precursor cells derived from human embryonic stem cells, human iPS cells, and direct conversion by transdifferentiation of human adult cells in rodent model. These stem cells are modified to induce overexpression of neurotrophic factors in order to modulate the lesion microenvironment and stimulate endogenous regenerative responses post spinal cord injury. A part of my laboratory is also investigating application of upconversion nanoparticles in conjunction with near infrared-LED illumination system for the neuromodulation applications both in vitro and in vivo. The goal is to develop a semi-invasive tool for stimulating / inhibiting, with spatio-temporal precision, neuropathways situated deep in the nervous system (spinal cord, motor cortex, vagus nerve, sciatic nerve, etc.) selectively. We are also exploring novel biodegradable polymers to replace viral transfection carriers. These biodegradable polymers could also construct an alternative drug delivery transporter, which will be used to limit the secondary sub-acute phase of contusive spinal cord injury. In addition, my lab is studying the adult central nervous system capabilities of adaptive changes enabling reorganization and plasticity in spared neuropathways following neuro-trauma. I am interested in neuroengineering and technological developments with clinical and translational applications.

近期论文

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Ankshita Prasad, Daniel BL Teh., Agata Blasiak, Chao Chai, Yang Wu, Payam Md Gharibani, In-Hong Yang, Kah Leong Lim, Hyunsoo Yang, Xiaogang Liu, Angelo, H, ALL, “Static Magnetic Field Stimulation Enhances Oligodendrocyte Differentiation and Secretion of Neurotrophic Factors”, Scientific Reports,, Accepted June 2017. Hae Ung Lee, Agata Blasiak, Devansh R. Agrawal, Daniel Teh Boon Loong ,Nitish Thakor, Angelo H. All, John S. Ho, In Hong Yang, “Subcellular Electrical Stimulation of Neurons Enhances the Myelination of Axons by Oligodendrocytes”, PLOS ONE, Accepted June 2017. Juanjuan Peng, Animesh Samanta, Xiao Zeng, Sanyang Han, Lu Wang, Dongdong Daniel Teh BL, Nam-Young Kang, Sung-Jin Park, Angelo H ALL, Wenxuan Juang, Lin Yuan, Xiaogang Liu, Young-Tae Chang, “Real-time in vivo hepatotoxicity monitoring through chromophore-conjugated upconversion nanoprobes”, J. Angewandte Chemie, Accepted Feb 2017 – DOI: 10.1002/anie.201612020R1 and 10.1002/ange.201612020R1 Sanyang Han, Animesh Samanta, Xioji Xie, Ling Huang, Juanjuang Peng, Sung Jin Park, Daniel Teh BL, Yongdoo Choi, Young-Tae Chang, Angelo H All*, Yanmei Yang, Bengang Xing, Xiaogang Liu, “Gold and Hairpin DNA Functionalization of Upconversion Nanocrystal for Imaging and in vivo Drug Delivery”, J. Advanced Materials, Accepted Feb. 2017. *Co-corresponding author Liangliang Liang, Xiaoji Xie, Daniel Teh Boon Loong, Angelo Homayoun All*, Ling Huang*, and Xiaogang Liu*, “Designing Upconversion Nanocrystals Capable of 745 nm Sensitization and 803 nm Emission for Deep-Tissue Imaging“, Chemistry. 2016 Jul 25;22(31):10801-7. doi: 10.1002/chem.201602514. Epub 2016 Jun 27. PMID: 27245472 DOI: 10.1002/chem.201602514 *Co-corresponding author Ashwati Vipin*, Thow Xin Yuan*, Hasan Mir, Jukka Kortelainen, Janani Manivannan, Hasan Al-Nashash, Angelo H ALL^, “Natural progression of spinal cord transection injury and reorganization of neural pathways“, J Neurotrauma. 2016 Jun 27, PMID: 27159651 – DOI: 10.1089/neu.2015.4383 Ankshita Prasad, Janani Manivannan, Daniel Teh Boon Loong, Soo Min Chua, Payam M.Gharibani, Angelo H. ALL, “A Review of iPSC, Direct Conversion by Trans-differentiation, Direct Reprogramming and Oligodendrocyte Differentiation”, J. Regenerative Medicine. 2016 Mar;11(2):181-91. PMID: 26857809 Faith Bazley, Cyndi Liu, Xuan Yuan; Haiping Hao; Angelo All, De Los Angeles A., Elias Zambidis, Joh Gearhart, Candace Kerr, “Direct Reprogramming of Human Primordial Germ Cells into Induced Pluripotent Stem Cells: Efficient Generation of Genetically Engineered Germ Cells“, Stem Cells and Development, Stem Cells Dev. 2015 Nov 15;24(22):2634-48. doi: 10.1089/scd.2015.0100. Epub 2015 Aug 10. PMID:26154167 Angelo H. All, Payam Gharibani, Siddharth Gupta, Faith A. Bazley, Nikta Pashai, Bin-Kuan Chou, Sandeep Shah, Linda M. Resar, Linzhao Cheng, John D. Gearhart, and Candace L. Kerr, “Early Intervention for Spinal Cord Injury with Human Induced Pluripotent Stem Cells Oligodendrocyte Progenitors”, PLoS One. 2015 Jan 30;10(1):e0116933. doi: 10.1371 /journal.pone.0116933. PMID: 25635918 Faith A. Bazley, Anil Maybhate, Tan Chuen Seng, Nitish V. Thakor, Candace Kerr, Angelo H. All, “Enhancement of bilateral cortical somatosensory evoked potentials to intact forelimb stimulation following thoracic contusion spinal cord injury in rats“, IEEE Transactions on Neural Systems and Rehabilitation Engineering, Volume: 22 , Issue: 5 , page 1-12, Sept. 2014 – ISSN:1534-4320 – Online ISSN: 1558-0210 – PMID:24801738. Angelo H. All, Faith A. Bazley, Siddharth Gupta; Nikta Pashai; Charles Hu; Amir Pourmorteza; Candace Kerr, “Human embryonic stem cell-derived oligodendrocyte progenitors aid in functional recovery of sensory pathways following contusive spinal cord injury“, PLoS One. 2012;7(10):e47645. doi: 10.1371/journal.pone.0047645. PMID: 23091637 – PMCID: PMC3473046 Nikta Pashai, Haiping Hao, Angelo All, Siddharth Gupta, Raghothama Chaerkady, Alejandro De Los Angeles, John D. Gearhart and Candace L. Kerr, “Genome-Wide Profiling of Pluripotent Cells Reveals a Unique Molecular Signature of Human Embryonic Germ Cells.”, PLoS ONE 2012;7(6):e39088. doi:10.1371/journal.pone.0039088. PMID:22737227&PMCID:PMC3380858 A. Maybhate, C. Hu, F. A. Bazley, Q. Yu, N. V. Thakor, C. Kerr, and A. All, “Potential Long Term Benefits of Acute Hypothermia after Spinal Cord Injury: Assessments with Somatosensory Evoked Potentials”, Crit Care Med. 2012 Feb;40(2):573-9. doi:0.1097/CCM.0b013e318232d97e. PMID: 22001581 , PMCID: PMC3261348 Chaerkady R, Letzen B, Renuse S, Sahasrabuddhe NA, Kumar P, All AH, Thakor NV, Delanghe B, Gearhart JD, Pandey A, Kerr CL, “Quantitative temporal proteomic analysis of human embryonic stem cell differentiation into oligodendrocyte progenitor cells”, Proteomics. 2011 Oct;11(20):4007-20. doi: 10.1002/pmic.201100107. PMID: 21770034, PMCID: PMC3728712 Shrivats Iyer, Anil Maybhate, Alessandro Presacco, Angelo H. All, “Multi-limb acquisition of motor evoked potentials and its application in spinal cord injury,” J Neurosci Methods. 2010 Nov 30;193(2):210-6. doi: 10.1016/j.jneumeth.2010.08.017. PMID:20832429 Brian S. Letzen, Cyndi Liu, Nitish V. Thakor, John D. Gearhart, Angelo H. All and Candace L. Kerr, “MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells,” PLoS One. 2010 May 5;5(5):e10480. doi: 10.1371/journal.pone.0010480. PMID:20463920, PMCID:PMC2864763