沈张奇 - 中国农业大学

个人简介

教授，博士生导师，获得国家杰出青年/优秀青年科学基金资助。主要致力于细菌致病及耐药机制研究，近年来，运用基因组学角度深入解析了猪链球菌、沙门氏菌、弯曲杆菌等病原菌致病的分子机制，发现了多个新型未知耐药机制，解析了这些耐药基因的遗传环境，阐明了其传播流行扩散的分子机制。主持国家自然科学基金及科技部国家重点研发计划课题7项；近五年，申请人以第一作者或者通讯作者（含共同）发表论文30余篇；先后受邀在国际动物疾病研究者会议（CRWAD）、空肠弯曲菌及相关细菌国际会议（CHRO）、环球食品安全及抗生素耐药性国际会议等做学术报告；参与编写5部英文专著，参与翻译《Plumb’s兽药手册》、《猪病学》等著作3部，参与制定兽药残留国家标准1项；目前担任《Microbiology Spectrum》编辑，还担任中国畜牧兽医学会兽医食品卫生学分会常务理事、北京市畜牧兽医学会理事、中国畜牧兽医学会兽医药理学和毒理学分会理事。教育经历 2007.08-2012.05 爱荷华州立大学兽医学院博士 2003.09-2006.07 中国农业大学动物医学院硕士 1999.09-2003.07 中国农业大学生物学院本科工作经历 2018.12-至今中国农业大学动物医学院教授 2016.03-2018.12 中国农业大学动物医学院副教授 2012.05-2016.03 爱荷华州立大学兽医学院博士后

研究领域

主要致力于细菌致病及耐药机制研究，近年来，运用基因组学角度深入解析了猪链球菌、沙门氏菌、弯曲杆菌等病原菌致病的分子机制，发现了多个新型未知耐药机制，解析了这些耐药基因的遗传环境，阐明了其传播流行扩散的分子机制

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Zhang P, Zhang X, Liu Y, Cui Q, Qin X, Niu Y, Wang C, Wang T, Chen Q, Ding S, Ma X, Shen Z. 2022. Genomic Insights into the Increased Occurrence of Campylobacteriosis Caused by Antimicrobial-Resistant Campylobacter coli. mBio 13:e0283522. Zhang C, Liu L, Zhang P, Cui J, Qin X, Ma L, Han K, Wang Z, Wang S, Ding S, Shen Z. 2022. Characterization of a Novel Gene, srpA, Conferring Resistance to Streptogramin A, Pleuromutilins, and Lincosamides in Streptococcus suis. Engineering 9:85-94. Yang L, Shen Y, Jiang J, Wang X, Shao D, Lam MMC, Holt KE, Shao B, Wu C, Shen J, Walsh TR, Schwarz S, Wang Y, Shen Z. 2022. Distinct increase in antimicrobial resistance genes among Escherichia coli during 50 years of antimicrobial use in livestock production in China. Nature Food 3:197-205. Wang X, Wang Y, Jiang X, Gong X, Wang Y, Shen Z. 2022. Co-transfer of mcr-8 with blaNDM-1 or tmexCD1-toprJ1 by plasmid hybridisation. Int J Antimicrob Agents 60:106619. Shen Y, Zhang R, Shao D, Yang L, Lu J, Liu C, Wang X, Jiang J, Wang B, Wu C, Parkhill J, Wang Y, Walsh TR, Gao GF, Shen Z. 2022. Genomic Shift in Population Dynamics of mcr-1-positive Escherichia coli in Human Carriage. Genomics Proteomics Bioinformatics doi:10.1016/j.gpb.2022.11.006. Liu D, Wang T, Shao D, Song H, Zhai W, Sun C, Zhang Y, Zhang M, Fu Y, Zhang R, He T, Lv Z, Bai L, Wu C, Ke Y, Wang Y, Shen Z. 2022. Structural diversity of the ISCR2-mediated rolling-cycle transferable unit carrying tet(X4). Sci Total Environ 826:154010. Dong N, Zeng Y, Wang Y, Liu C, Lu J, Cai C, Liu X, Chen Y, Wu Y, Fang Y, Fu Y, Hu Y, Zhou H, Cai J, Hu F, Wang S, Wang Y, Wu Y, Chen G, Shen Z, Chen S, Zhang R. 2022. Distribution and spread of the mobilised RND efflux pump gene cluster tmexCD-toprJ in clinical Gram-negative bacteria: a molecular epidemiological study. Lancet Microbe 3:e846-e856. Ma L, Zhang W, Ma J, Cui Q, Zhang C, Zhang P, Sun C, Sun H, Zhu Y, Wang S, Ding S, Hu G, Shen Z. 2021. Genomic Insight into the Antimicrobial Resistance of Streptococcus Suis - Six Countries, 2011-2019. China CDC Wkly 3:994-998. Zhang R, Dong N, Shen Z, Zeng Y, Lu J, Liu C, Zhou H, Hu Y, Sun Q, Cheng Q, Shu L, Cai J, Chan EW, Chen G, Chen S. 2020. Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X). Nat Commun 11:4648. Wang X, Wang Y, Ling Z, Zhang C, Fu M, Wang Y, Wang S, Zhang S, Shen Z. 2020. Peptide nucleic acid restores colistin susceptibility through modulation of MCR-1 expression in Escherichia coli. J Antimicrob Chemother 75:2059-2065. Shen Z, Hu Y, Sun Q, Hu F, Zhou H, Shu L, Ma T, Shen Y, Wang Y, Li J, Walsh TR, Zhang R, Wang S. 2018. Emerging Carriage of NDM-5 and MCR-1 in Escherichia coli From Healthy People in Multiple Regions in China: A Cross Sectional Observational Study. EClinicalMedicine 6:11-20. Shen Y, Wu Z, Wang Y, Zhang R, Zhou HW, Wang S, Lei L, Li M, Cai J, Tyrrell J, Tian GB, Wu C, Zhang Q, Shen J, Walsh TR, Shen Z. 2018. Heterogeneous and Flexible Transmission of mcr-1 in Hospital-Associated Escherichia coli. mBio 9. Li Y, Sun QL, Shen Y, Zhang Y, Yang JW, Shu LB, Zhou HW, Wang Y, Wang B, Zhang R, Wang S, Shen Z. 2018. Rapid Increase in Prevalence of Carbapenem-Resistant Enterobacteriaceae (CRE) and Emergence of Colistin Resistance Gene mcr-1 in CRE in a Hospital in Henan, China. J Clin Microbiol 56. Yao H, Shen Z, Wang Y, Deng F, Liu D, Naren G, Dai L, Su CC, Wang B, Wang S, Wu C, Yu EW, Zhang Q, Shen J. 2016. Emergence of a Potent Multidrug Efflux Pump Variant That Enhances Campylobacter Resistance to Multiple Antibiotics. mBio 7. Shen Z, Patil RD, Sahin O, Wu Z, Pu XY, Dai L, Plummer PJ, Yaeger MJ, Zhang Q. 2016. Identification and functional analysis of two toxin-antitoxin systems in Campylobacter jejuni. Mol Microbiol 101:909-23.