唐军 - 中国农业大学

个人简介

教育经历 1995/9 - 2001/5，美国麻省大学，分子与细胞生物学，博士，导师：David Gross 1991/9 - 1994/7，河北师范大学，细胞生物学，硕士，导师：孙大业 1987/9 - 1991/7，兰州大学，生物化学，学士工作经历 2009/4 - 至今，中国农业大学，动物医学院，教授 2006/6 – 2008/12, 美国宾夕法尼亚大学，医学院癌症中心，Research Associate 2001/6 – 2006/5, 美国宾夕法尼亚大学，医学院癌症中心，博士后

研究领域

肿瘤细胞信号转导以及动物抗病毒感染机制研究。具体方向包括：1) 比较肿瘤学与细胞信号转导调控（Comparative Oncology & Signaling Transduction），主要以禽类和伴侣动物多发的肿瘤性疾病为模型，与人类肿瘤疾病进行比较医学方面的研究，侧重于研究肿瘤发生和发展的信号转导机制及调控途径。2) 病毒与宿主相互作用机制（Herpes virus & Host Interaction），主要以人类和动物模式病毒（如疱疹病毒HSV-1和PRV等）为模型和载体，研究病毒感染与宿主间的相互作用机制，重点关注病毒与宿主天然免疫信号分子的互作机制，并为动物和人类肿瘤疾病的基因和药物治疗提供载体。3）亚细胞核体（PML-NBs）的功能与调控。4）化学小分子的抗肿瘤和抗病毒活性

近期论文

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Zhang R, Chen S, Zhang Y, Wang M, Qin C, Yu C, Zhang Y, Li Y, Chen L, Zhang X, *Yuan X, *Tang J. (2021). Pseudorabies Virus DNA Polymerase Processivity Factor UL42 Inhibits Type I Interferon Response by Preventing ISGF3-ISRE Interaction. Journal of Immunology. 207 (2) 613-625. Yu C, Xu A, Lang Y, Qin C, Yuan X, Feng W, Wang M, Gao C, Chen J, *Zhang R and *Tang J. (2020). Swine Promyelocytic Leukemia Isoform II Inhibits Pseudorabies Virus Infection by Suppressing Viral Gene Transcription in PML-NBs. Journal of Virology. doi.org/10.1101/2020.03.23.004697. *Zhang R, Cui D, Xue T, Lang Y, Li, Sun H, Kuang Y, Li G and *Tang J. (2020). HLA-B-associated transcript 3 (Bat3) stabilizes and activates p53 in a HAUSP-dependent manner. Journal of Molecular Cell Biology. 12(2):99-112. （封面文章） Shao A, Lang Y, Wang M, Qin C, Kuang Y, Mei Y, Lin D, Zhang S, *Tang J. (2020). Bclaf1 is a direct target of HIF-1 and critically regulates the stability of HIF-1α under hypoxia. Oncogene. 29:2807-2818. Qin C, Zhang R, Lang Y, Shao A, Xu A, Feng W, Han J, Wang M, He W, Yu C, *Tang J. (2019). Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3. PLoS Pathogen 15, e1007559. Li, C., Peng, Q., Wan, X., Sun, H., and *Tang J. (2017). C-terminal motifs in promyelocytic leukemia protein isoforms critically regulate PML nuclear body formation. J Cell Sci 130, 3496-3506. Zhang R, Xu A, Qin C, Zhang Q, Chen S, Lang Y, Wang M, Li C, Feng W, Zhang R, Jiang Z, and *Tang J. (2017). Pseudorabies Virus dUTPase UL50 Induces Lysosomal Degradation of Type I Interferon Receptor 1 and Antagonizes the Alpha Interferon Response. Journal of Virology 91: e 01148-17. Shao, A.W., Sun, H., Geng, Y., Peng, Q., Wang, P., Chen, J., Xiong, T., Cao, R., and *Tang J. (2016). Bclaf1 is an important NF-kappaB signaling transducer and C/EBPbeta regulator in DNA damage-induced senescence. Cell Death Differ 23, 865-875. Zheng J, Lang Y, Zhang Q, Cui D, Sun H, Jiang J, Jiang L, Chen Z, Zhang R, Gao Y, Tian W, Wu W, *Tang J, *Chen Z. (2015). Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation. Genes Dev. 29,1524-34. Cui D., Li LJ, Lou HJ., Sun HL, Ngai S-M, Shao GZ, and *Tang J. (2014) The ribosomal protein S26 regulates p53 activity in response to DNA damage. Oncogene 33,2225-35.