周磊 - 中国农业大学

个人简介

教育经历 2005-2010，中国农业大学，预防兽医学，博士 2000-2005，中国农业大学，动物医学，本科工作经历 2020-至今，中国农业大学动物医学院预防兽医系，副教授/博士生导师 2015-2019，中国农业大学动物医学院预防兽医系，副教授 2010-2014，中国农业大学动物医学院预防兽医系，讲师 2011-2013，美国弗吉尼亚理工大学兽医学院生物医学与病理系，博士后 2005-2010，农业部动物分子流行病学与人兽共患病重点实验室，研究助理获奖及荣誉 2021年中国农业大学2021届本科生“优秀毕业论文”优秀指导教师奖 2017年中国农业大学2017届本科生“百篇优秀毕业论文（设计）”优秀指导教师奖 2016年大北农优秀青年研究者奖 2016年勃林格殷格翰年度PRRS研究进展奖 2012年全国百篇优秀博士论文奖 2011年北京市优秀博士论文奖

研究领域

猪繁殖与呼吸综合征病毒（PRRSV）的病原学、分子流行病学、感染与免疫、致病机制和新型疫苗创制研究

近期论文

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Wu Weixin, Ge Xinna; Zhang Yongning, Han Jun, Guo Xin, Zhou Lei* co, Yang Hanchun* co. Evolutionary Patterns of Codon Usage in Major Lineages of Porcine Reproductive and Respiratory Syndrome Virus in China, Viruses. 2021. 13, no. 6: 1044. Zhou Lei, Ge X, Yang H. Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A “Leaky” Vaccine with Debatable Efficacy and Safety. Vaccines. 2021;9:362. Zhou X, Ge X, Zhang Y, Han J, Guo X, Chen Y, Zhou Lei * co Yang, H* co. Attenuation of porcine deltacoronavirus disease severity by porcine reproductive and respiratory syndrome virus coinfection in a weaning pig model. Virulence. 2021;12:1011-21. Zhou, Xco, Zhou Leico, Zhang, P, Guo, X., Han, J. and Yang, H. A strain of porcine deltacoronavirus: Genomic characterization, pathogenicity and its full‐length cDNA infectious clone. Transbound Emerg Dis. 2020; 00: 1– 17. https://doi.org/10.1111/tbed.13862 Su, J., Zhang, X., He, B., Ge, X., Han, J., Zhou Lei * co, Guo, X* co. and Yang, H., 2019. Identification of three site mutations in nonstructural protein 1β, glycoprotein 3 and glycoprotein 5 that correlate with increased interferon α resistance of porcine reproductive and respiratory syndrome virus. Veterinary Microbiology, p.108395. Zhang, Zco., Zhou Leico ，Ge, X., Guo, X., Han, J. and Yang, H., 2018. Evolutionary analysis of six isolates of porcine reproductive and respiratory syndrome virus from a single pig farm: MLV-evolved and recombinant viruses. Infection, Genetics and Evolution, 66, pp.111-119. Jiang Nan; Jin Huan; Li Yi; Ge Xinna; Han Jun; Guo Xin; Zhou Lei *; Yang Hanchun, 2017. Identification of a novel linear B-cell epitope in nonstructural protein 11 of porcine reproductive and respiratory syndrome virus that are conserved in both genotypes , PLos One, 12(11): 0~e0188946 Cui Zhengzhi; Niu Shuaishuai; Liu Jingjing; Xu Lei; Dai Yunping; Li Ning; Kang Youmin; Zhang Linlin *co; Zhou Lei*co ; Yu Shuyang*co ,2017. Over-expression of CD163, CD169, and CD151 is not sufficient to improve the susceptibility to porcine reproductive and respiratory syndrome virus infection in transgenic mice , Science Bulletin, 62(24): 1634~1636 Gao, Xiang, Dongliang Li, Jingyi Zhao, Farong Xu, Xinna Ge, Xin Guo, Jun Han, Hanchun Yang, and Zhou Lei*, 2016. Complete genome sequence of porcine epidemic diarrhea virus from an outbreak in a vaccinated farm in Shandong, China. Genome announcements 4, no. 4 (2016): e00619-16. Zhou Leico, Yang Beinaco, Xu Lei., Jin, H., Ge, X., Guo, X., Yang, H. 2017. Efficacy evaluation of three modified-live virus vaccines against a strain of porcine reproductive and respiratory syndrome virus NADC30-like. Veterinary Microbiology. Han Junco, Zhou Leico , Yang Hanchun, 2017.Pathogenesis and control of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus." Veterinary Microbiology (2017). Zhou Leico, Zichun Wangco, Yuping Ding, Xinna Ge, Xin Guo, Hanchun Yang， 2015. NADC30-like Strain of Porcine Reproductive and Respiratory Syndrome Virus, China. Emerging infectious diseases 21.12 (2015): 2256. Li Yco, Zhou Leico, Zhang JL, Ge XN, Zhou R, Zheng HG, Geng G, Guo X, Yang HC. 2014. NSP9 and NSP10 Contribute to the Fatal Virulence of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Emerging in China. PLoS pathogens. 10, e1004216. Li Wangco, Zhou Leico, Han Zhang, Yan Li, Xinna Ge, Xin Guo, Kangzhen Yu, Hanchun Yang,2014 Interactome Profile of the Host Cellular Proteins and the Nonstructural Protein 2 of Porcine Reproductive and Respiratory Syndrome Virus. PLoS ONE 9(6): e99176. doi:10.1371/journal.pone.0099176 Zhou Lei, Xiaorong Yang, Yuan Tian, Xinna Ge, Xin Guo, Hanchun Yang, 2014 Genetic Diversity Analysis of Genotype 2 Porcine Reproductive and Respiratory Syndrome Viruses Emerging in Recent Years in China. BioMed Research International, vol. 2014, Article ID 748068, 13 pages, 2014. doi:10.1155/2014/748068 Zhou Lei, Ni Y-Y, Pi?eyro P, Cossaboom CM, Subramaniam S, Dryman, B., Huang, Y.-W., Cao, D.-J., Meng, X.-J. 2013.Broadening the Heterologous Cross-Neutralizing Antibody Inducing Ability of Porcine Reproductive and Respiratory Syndrome Virus by Breeding the GP4 or M genes. PLoS ONE 8(6): e66645. doi:10.1371/journal.pone.0066645 Zhou Lei, Ni, Y.-Y., Pi?eyro, P., Sanford, B., Cossaboom, C., Dryman, B., Huang, Y.-W., Cao, D.-J., Meng, X.-J., 2012. DNA shuffling of the GP3 genes of porcine reproductive and respiratory syndrome virus (PRRSV) produces a chimeric virus with an improved cross-neutralizing ability against a heterologous PRRSV strain. Virology434, 96-109. Zhou, Lei, Yang, H., 2010. Porcine reproductive and respiratory syndrome in China. Virus research154, 31-37. Zhou, Leico, Chen, Sco., Zhang, J., Zeng, J., Guo, X., Ge, X., Zhang, D., Yang, H., 2009a. Molecular variation analysis of porcine reproductive and respiratory syndrome virus in China. Virus research145, 97-105. Zhou, Leico, Zhang, J. co, Zeng, J., Yin, S., Li, Y., Zheng, L., Guo, X., Ge, X., Yang, H., 2009b. The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence. Journal of virology83, 5156-5167.