个人简介
工作经历
2024/05-至今 中山大学公共卫生学院（深圳），教授
2018/06-2024/04 中国农业大学动物医学院，教授
2013/06-2018/01 华盛顿大学医学院（圣路易斯），博士后
2010/07-2013/05 英国纽卡斯尔大学医学院，玛丽居里博士后
教育经历
2005/11-2010/07 捷克国家科学院寄生虫学/南波西米亚大学，寄生虫的分子与细胞生物学，哲学博士
2003/09-2005/07 中山大学生命科学学院，海洋生物学，理学硕士
1997/09-2001/07 湖南农业大学生命科学学院，生物技术，理学学士
承担课题及科研项目
1.国家自然科学基金委员会，面上项目，2019-2022，项目负责人，结题
2.国家自然科学基金委员会，面上项目，2022-2025，项目负责人，在研
3.十四五重点研发计划子任务，弓形虫分泌细胞器的形成机制，2022-2025，子任务负责人，在研
4.十四五重点研发项目子任务，弓形虫突变株疫苗研制，2023-2027，子任务负责人，在研
5.北京市自然科学基金，面上项目，2020-2022，项目负责人，结题
6.中国农业大学，“杰出人才”教授启动经费，2018-2023，项目负责人，结题
7.中山大学，教研型教授，引进人才启动经费，2024-2027，项目负责人，在研
近期论文
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Sun M, Tang T, He Kai, Long S. TBC9, an essential TBC-domain protein, regulates early vesicular transport and IMC formation in Toxoplasma gondii. Communications Biology. 2024, 7:596.
Li YB, He K, Dong H, Ding HY, Tang XT, Wu XT, Chen XW, Wu RB, Wang QQ, Aleem MT, Long S. A Sarcocystidae-specific striated fiber assemblin protein SFA5 is required for parasite division in Toxoplasma gondii. One Health Advances. 2024, 2:15.
Dong H, Yang J, He K, Zheng WB, Lai DH, Liu J, Ding HY, Wu RB, Brown KM, Hide G, Lun ZR, Zhu XQ, Long S. The Toxoplasma monocarbxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival. ELife. 2024, 12:RP88866.
Wu XT, Wang QQ, Gao XW, Dong H, Ding HY, Wu XT, Chen XW, Wu RB, Wang QQ, Aleem MT, Long S. The plant-like protein phosphatase PPKL regulates parasite replication and morphology in Toxoplasma gondii. Parasites & Vectors. 2024, 17(1):142.
He K, Wang QQ, Gao XW, Tang T, Ding HY, Long S. Transcriptomic and metabolomic analyses reveal the essential nature of Rab1B in Toxoplasma gondii. Parasites & Vectors. 2023, 16(1):409.
Wang QQ, Sun M, Tang T, Lai DH, Liu J, Maity S, He K, Wu XT, Yang J, Li YB, Tang XY, Ding HY, Hide G, Distefano M, Lun ZR, Zhu XQ, Long S. Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting. mBio. 2023, 14(4):e0130923.
Wang QQ, He K, Aleem M, Long S. Prenyl transferases regulate secretory protein sorting and parasite morphology in Toxoplasma gondii. International Journal of Molecular Sciences. 2023. 24(8):7172.
Wan W, Dong H, Lai DH, Yang J, He K, Tang X, Liu Q, Hide G, Zhu XQ, Sibley LD, Lun ZR, Long S. The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments. Nature Communications. 2023, 14(1):977.
Long S, Brown KM, Sibley LD. 2018. Protein interactomes defined by BirA labeling in Toxoplasma gondii. Bio-Protocol. 8(6). pii: e2768.
Long S, Anthony B, Drewry L, Sibley LD. 2017. A Conserved ankyrin repeat containing protein CPH1 regulates conoid stability, motility and cell invasion in Toxoplasma. Nature Communications. 2017, 8(1):2236.
Long S; Brown KM; Drewry LL; Anthony B; Phan IQ; Sibley LD. 2017. Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii. PLoS Pathogens. 2017, 13(5):e1006379.
Long S, Wang QL, Sibley LD. 2016. Analysis of noncanonical calcium-dependent protein kinases in Toxoplasma gondii by targeted gene deletion using CRISPR/Cas9. Infection and Immunity. 2016, 84(5):1262-73.
Brown KM, Long S, Sibley LD. 2018. Conditional Knockdown of Proteins Using Auxin-inducible Degron (AID) Fusions in Toxoplasma gondii. Bio-Protocol, 8(4):e2728.
Long S, Jirků M, Ayala FJ, Lukeš J. 2008. Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei. Proc. Natl. Acad. Sci. USA. 2008, 105(36): 13468-13473.
Long S, Jirků M, Mach J, Ginger ML, Sutak R, Des Richardson R, Tachezy J, Lukeš J. 2008. Ancestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes. Mol. Microbiol. 2008, 69: 94-109.
Long S, Piya C, Tsaousis DA, Skalicky T, Verner Z, Wen YZ, Roger AJ, Lukeš J. 2011. Stage-specific essentiality of Isa1 and Isa2, mitochondrial Fecluster assembly proteins in the excavate protist Trypanosoma brucei. Mol. Microbiol. 2011, 81(6): 1403-1418.
Long S, Vavrova Z, Lukeš J. 2008. The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei. Mol. Biochem. Parasitol. 2008.11, 162: 100-104.
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