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个人简介

教育经历 1994年-- 1998年 中国农业大学 攻读兽医学学士学位,获学士学位 1998年-- 2000年 中国农业大学 攻读预防兽医学硕士学位,获硕士学位 2000年-- 2003年 中国农业大学 攻读预防兽医学博士学位,获博士学位 工作经历 2003年07月-2003年10月 中国农业大学动物医学院,助教 2003年11月-2005年12月 中国农业大学动物医学院,讲师 2006年01月-2013年12月 中国农业大学动物医学院,副教授 2011年02月-2012年02月 英国爱丁堡大学Roslin研究所,访问学者 2014年01月- 中国农业大学动物医学院,教授

研究领域

主要从事外寄生虫生物学、寄生虫病防治新技术研究和抗寄生虫新兽药及新制剂的研制。研制出奶牛专用抗寄生虫新药——乙酰氨基阿维菌素原料药、注射液、浇泼剂,获国家新兽药证书;制定出乙酰氨基阿维菌素原料药质量标准、注射液和浇泼剂质量标准,被农业部颁布为行业标准。建立牛奶中乙酰氨基残留检测方法,被农业部和卫生部颁布为国家标准。乙酰氨基阿维菌素是一种可应用于奶牛且不需休药期的广谱抗寄生虫药,有利于提高我国奶牛寄生虫的防治水平,减少因寄生虫感染给奶牛养殖业造成的经济损失。 利用固体分散体技术和混悬剂技术,开展抗寄生虫长效制剂的研制,长效伊维菌素注射剂的研制获得Bill & Melinda Gates Foundation资助;研制出阿维菌素长效注射液(油悬剂),已被投入生产使用;研制出微环境改良妥曲珠利固体分散体,并制备出混悬剂。长效制剂可以有效防止动物寄生虫的反复感染,减少动物用药次数,方便用药。参与吡喹酮纳米注射剂的研制。利用原位凝胶技术,研制吡喹酮原位凝胶注射剂。 开展蜱、螨等媒介节肢动物的生物学和在疾病传播中的作用研究。在国内外率先建立起成熟可靠的鸡皮刺螨实验室养殖系统,开展鸡皮刺螨聚集机制(聚集信息素)、卵发育机制、抗药性研究、疫苗研制、共生菌与鸡皮刺螨互作机制和防治新型药剂研制,为我国鸡皮刺螨的防控提供新型技术支撑。

近期论文

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Zhang Shudong, Xu Xiaolin, Sun Weiwei, Zhang Zhe, Pan Baoliang, Hu Qin. Enteric and hydrophilic polymers enhance dissolution and absorption of poorly soluble acidic drugs based on micro-environmental pH-modifying solid dispersion. European Journal of Pharmaceutical Sciences. 2022,168:106074. Xiaolin Xu, Chuanwen Wang, Qi Liu, Yu Huang, Weiwei Sun, Baoliang Pan. Two ferritins from Dermanyssus gallinae: characterization and in vivo assessment as protective antigens. Pest Management Science 2022,78(2):561-571. Xu Xiaolin, Zhang Shudong, Wang Chuanwen, Li Hao, Huang Yu, Ma Yuyun, Zhao Jiayi, Pan Tingting, Li Huan, Pan Baoliang. Pharmacokinetics of toltrazuril and its metabolites after oral and parenteral administration of novel oil-based suspension based on micro-environmental pH-modifying solid dispersion in rabbits. Veterinary Parasitology. 2021, 299:109580. Hao Li, Jie Li, Qiang Wan, Mengdong Wang, Jiayi Zhao, Huan Li, Weiwei Sun, Baoliang Pan. Bioremediation mechanism of Monensin contaminated chicken manure by a combination of housefly larvae and Stenotrophomonas sp. DM-2. Environmental Technology & Innovation. 2021, 21, 101269 Li, Hao, Li Jie, Wan Qiang, Wang Mengdong, Zhao Jiayi, Li Huan, Sun Weiwei, Pan Baoliang. Bioremediation mechanism of Monensin contaminated chicken manure by a combination of housefly larvae and Stenotrophomonas sp. DM-2. Environmental Technology & Innovation. 2021, 21:101269 Chuanwen Wang, Xiaolin Xu, Yu Huang, He Yu, Hao Li, Qiang Wan, Huan Li, Lianyu Wang, Yanyan Sun, Baoliang Pan. Susceptibility of Dermanyssus gallinae from China to acaricides and functional analysis of glutathione S-transferases associated with beta-cypermethrin resistance. Pesticide Biochemistry and Physiology. 2021, 171:104724 Xiaolin Xu, Chuanwen Wang, Yu Huang, Shudong Zhang, He Yu, Jiali Meng, Baoliang Pan. Evaluation of the vaccine efficacy of three digestive protease antigens from Dermanyssus gallinae using an in vivo rearing system. Vaccine. 2020, 38:7842–7849 Yu Huang, Huan Li, Chuanwen Wang, Xiaolin Xu, He Yu, Jali Meng, Xiaoxiao Qi, Bohan Wang, Baoliang Pan. De novo assembly and discovery of genes related to blood digestion in the transcriptome of Dermanyssus gallinae (Acari: Dermanyssidae). Veterinary Parasitology. 2020, 286:109246. Huan Li, Yu Huang, Jingwei Wang, He Yu, Jiayi Zhao, Qiang Wan, Xiaoxiao Qi, Hao Li, Chuanwen Wang, Baoliang Pan. Molecular and biochemical characterization of enolase from Dermanyssus gallinae. Gene. 2020, 756:144911 Chuanwen Wang, Xiaolin Xu, He Yu, Yu Huang, Qiang Wan, Hao Li, Baoliang Pan. Low-Temperature Storage of the Poultry Red Mite, Dermanyssus gallinae, Facilitates Colony Mantainance and Population Growth. Parasitology. 2020, 147(7):740-746. Chuanwen Wang, Xiaolin Xu, Yu Huang, He Yu, Hao Li, Qiang Wan, Baoliang Pan. Transcription profiling and characterization of Dermanyssus gallinae cytochrome P450 genes and their transcription profiling involved in beta-cypermethrin resistance. Veterinary Parasitology. 2020, ? 283: 109155 Li, Hao; Li, Jie; Wan, Qiang; et al. Monensin biodegradation pathway and role of epoxide hydrolase in Stenotrophomonas maltophilia DM-2. Journal of Chemical Technology & Biotechnology. 2020, 95(6): 1825-1833 Chuanwen Wang, Yu Huang, Jiayi Zhao, Yuyun Ma, Xiaolin Xu, Qiang Wan, Hao Li, Baoliang Pan. First record of Aspergillus oryzae as an entomopathogenic fungus against the poultry red mite Dermanyssus gallinae. Veterinary Parasitology. 2019, 271:57-63. Xiaolin Xu, Chuanwen Wang, Shudong Zhang, Yu Huang, Tingting Pan, Bohan Wang, Baoliang Pan. Acaricidal efficacy of orally administered Macrocyclic Lactones against poultry red mites (Dermanyssus gallinae) on chicks and their impacts on mite reproduction and blood meal digestion. Parasites & Vectors. 2019,12(1):345. Wan Q, Zhao J, Li H, Li H, Wang C, Pan B. The wetting behavior of three different types of aqueous surfactant solutions on housefly (Musca domestica) surfaces. Pest Manag Sci. 2019, 76 (3): 1085-1093. Chuanwen Wang, Yuyun Ma, Yu Huang, Shanchun Su, Lianyu Wang, Yanyan Sun, Qiang Wan, Hao Li, Shudong Zhang, ?ivind ?ines, Baoliang Pan. Darkness increases the population growth rate of the poultry red mite, Dermanyssus gallinae. Parasites & Vectors. 2019, 12:213 Wan Q, Li H, Zhang S, Wang C, Su S, Long S, Pan B. Combination of active behaviors and passive structures contributes to the cleanliness of housefly wing surfaces: A new insight for the design of cleaning materials. Colloids Surf B Biointerfaces. 2019, 180: 473-480. (IF 3.997) Zhang S, Wan Q, Xu X, Xing Y, Ding J, Yang S, Sun W, Lu M, Pan B. A novel oil-based suspension of a micro-environmental, pH-modifying solid dispersion for parenteral delivery: Formulation and stability evaluation. Colloids Surf B Biointerfaces. 2019, 179:382-392. Shudong Zhang, Qiang Wan, Yidan Xing, Jiafeng Ding, Shizhuang Yang, Weiwei Sun, Mengmeng Lu, Baoliang Pan. Formulation and evaluation of a novel oral oil-based suspension using micro-environmental pH-modifying solid dispersion. AAPS PharmSciTech. 2019, 20(2):75. Hao Li, Qiang Wan, Shudong Zhang, Chuanwen Wang, Shanchun Su, Baoliang Pan. Housefly larvae (Musca domestica) significantly accelerates degradation of monensin by altering the structure and abundance of the associated bacterial community. Ecotoxicology and Environmental Safety. 2019,170: 418–426. (IF 3.974) Lu M, Cai Y, Yang S, Wan Q, Pan B. A single subcutaneous administration of a sustained-release ivermectin suspension eliminates Psoroptes cuniculi infection in a rabbit farm. Drug Dev Ind Pharm. 2018, 19:1-5. Chuanwen Wang, Yuyun Ma, Yu Huang, Jianhai Xu, Jinzhong Cai, Baoliang Pan. An e?cient rearing system rapidly producing large quantities of poultry red mites, Dermanyssus gallinae (Acari: Dermanyssidae), under laboratory conditions. Veterinary Parasitology, 2018,258:38–45. Sun W, Pan B. Effect of micro-environment modification and polymer type on the in-vitro dissolution behavior and in-vivo performance of amorphous solid dispersions. Eur J Pharm Sci. 2017, 104:240-254. Lu M, Xiong D, Sun W, Yu T, Hu Z, Ding J, Cai Y, Yang S, Pan B. Sustained release ivermectin-loaded solid lipid dispersion for subcutaneous delivery: in vitro and in vivo evaluation. Drug Deliv. 2017, 24(1):622-631.

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