周文忠 - 中国农业大学

个人简介

1993年毕业于复旦大学遗传学专业，获得理学博士学位。之后分别在上海医科大学（复旦大学医学部）、日本大阪大学细胞及分子生物学研究所、美国内布拉斯加大学医学中心、加拿大麦克马斯特大学医学部等单位从事教学和科研工作。2005年归国至今在中国农业大学动物医学院从事纳米兽药和纳米佐剂相关科研工作，承担过“863计划”，“国家科技支撑计划”等课题。研究工作集中在两个方面：（1）纳米兽药：纳米兽药的构建、纳米技术促进兽药吸收、改善兽药功效的作用、影响因素及其机理，纳米兽药的安全性等；（2）纳米佐剂：纳米佐剂的构建、纳米佐剂对抗原蛋白和基因疫苗细胞和体液免液的增强作用、纳米粒的理化特征对其佐剂效应的影响等。获得了具有自主知识产权的成果，以第一作者或通讯作者发表SCI收录论文20余篇，在该领域取得一系列创新性成果发表在Part Fibre Toxicol，Nanomedicine，Colloids Surf B Biointerfaces，Int J Nanomedicine，IET Nanobiotechnol., Drug Deliv.等极具行业影响力期刊。获得内蒙古科技进步一等奖、中华农业科技奖二等奖、“北京市科学技术奖二等奖”等省市级奖励。获得授权发明专利多项，参与制定奶牛性控国家标准2项。

研究领域

研究工作集中在两个方面：（1）纳米兽药：纳米兽药的构建、纳米技术促进兽药吸收、改善兽药功效的作用、影响因素及其机理，纳米兽药的安全性等；（2）纳米佐剂：纳米佐剂的构建、纳米佐剂对抗原蛋白和基因疫苗细胞和体液免液的增强作用、纳米粒的理化特征对其佐剂效应的影响等

近期论文

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W-Z Zhou, D.S.B. Hoon, S.K.S. Huang, S. Fujii, K. Hashimoto, R. Morishita, and Y. Kaneda, 1999, RNA melanoma vaccine: Induction of anti-tumor immunity by human Glycoprotein 100 mRNA immunization. Human Gene Therapy. 10 (16): 2719-2724. W-Z Zhou, Y. Kaneda, S.K.S. Huang, R. Morishita, and D.S.B. Hoon, 1999, Protective immunization against melanoma by gp100 DNA-HVJ-liposome vaccine. Gene Therapy. 6: 1768-1773. Wenzhong Zhou, Jinshui Yang et al., 1996, Introduction of a foreign gene into rice cells by particle bombardment. ACTA BIOLOGIAE EXPREMENTALIS SINICA. 29(1): 89-93. 通讯作者论文 Wang T, Chen X, Lu M, Li X, Zhou W. Preparation, characterization and antibacterial activity of a florfenicol-loaded solid lipid nanoparticle suspension. IET Nanobiotechnol. 2015 Dec;9(6):355-61. doi: 10.1049/iet-nbt. 2015.0012. Chen XJ, Wang T, Lu MM, Zhu LY, Wang Y, Zhou WZ. Preparation and evaluation of tilmicosin-loaded hydrogenated castor oil nanoparticle suspensions of different particle sizes. Int J Nanomedicine. 2014 May 27;9:2655-64. doi: 10.2147/IJN.S58898. eCollection 2014. Wang Y, Zhu LY, Dong Z, Xie SY, Chen XJ, Lu MM, Wang XF, Li XH, Zhou WZ. Preparation and stability study of norfloxacin-loaded solid lipid nanoparticle suspensions. Colloids Surf B Biointerfaces, 98:105-11, 2012. Wang XF, Zhang SL, Zhu LY, Xie SY, Dong Z, Wang Y, Zhou WZ. Enhancement of antibacterial activity of tilmicosin against Staphylococcus aureus by solid lipid nanoparticles in vitro and in vivo. Vet J. 2012 Jan; 191(1):115-20. Epub 2011 Sep 6. Xie S, Pan B, Shi B, Zhang Z, Zhang X, Wang M, Zhou W. Solid lipid nanoparticle suspension enhanced the therapeutic efficacy of praziquantel against tapeworm. Int J Nanomedicine, 2011; 6:2367-74. Epub 2011 Oct 18. Xie S, Wang F, Wang Y, Zhu L, Dong Z, Wang F, Li X, Zhou W. Acute toxicity study of tilmicosin-loaded hydrogenated castor oil-solid lipid nanoparticles. Part Fibre Toxicol. 2011 Nov 20;8:33. doi: 10.1186/1743-8977-8-33. Zhu, LY, Xie SY, Dong Z, Wang XF, Wang Y, Zhou WZ. Effects of PLGA on preparation and characteristics of plasmid DNA-loaded solid lipid nanoparticles. IET Nanobiotechnol, 2011 Sep; 5(3):79-85. Dong Z, Xie S, Zhu L, Wang Y, Wang X, Zhou W. Preparation and in vitro, in vivo evaluations of norfloxacin-loaded solid lipid nanopartices for oral delivery. Drug Deliv. 2011 Aug; 18(6):441-50. Epub 2011 May 10. Xie S, Zhu L, Dong Z, Wang Y, Wang X, Zhou W. Preparation and evaluation of ofloxacin-loaded palmitic acid solid lipid nanoparticles. Int J Nanomedicine, 2011, 6; 547-555. Xie S, Zhu L, Dong Z, Wang X, Wang Y, Li X, Zhou W. Preparation, characterization and pharmacokinetics of enro?oxacin-loaded solid lipid nanoparticles: In?uences of fatty acids. Colloids Surf B Biointerfaces. 2011 Apr 1;83(2):382-7. Epub 2010 Dec 14. Xie S, Pan B, Wang M, Zhu L, Wang F, Dong Z, Wang X, Zhou W. Formulation, characterization and pharmacokinetics of praziquantel-loaded hydrogenated castor oil solid lipid nanoparticles. Nanomedicine, 2010 Jul; 5(5):693-701. Li S, Zhao B, Wang F, Wang M, Xie S, Wang S, Han C, Zhu L, Zhou W. Yak interferon-alpha loaded solid lipid nanoparticles for controlled release. Res Vet Sci. 2010 Feb; 88(1):148-53. Epub 2009 Aug 3. Xie S, Wang S, Zhu L, Wang F, Zhou W. The effect of glycolic acid monomer ratio on the emulsifying activity of PLGA in preparation of protein-loaded SLN. Colloids Surf B Biointerfaces. 2009 Nov 1; 74(1):358-61. Epub 2009 Aug 12. Wang SL, Xie SY, Zhu LY, Wang FH, Zhou WZ. Effects of PLGA as a co-emulsifier on the preparation and hypoglycemic activity of insulin-loaded solid lipid nanoparticles. IET Nanobiotechnol. 2009 Dec; 3(4):103-8. Han C, Qi CM, Zhao BK, Cao J, Xie SY, Wang SL, Zhou WZ. Hydrogenated castor oil nanoparticles as carriers for the subcutaneous administration of tilmicosin: in vitro and in vivo studies. J Vet Pharmacol Ther. 2009 Apr; 32(2):116-23. Xie, S.Y., Wang, S.L., Zhao, B.K., Han, C., Zhou, W. Z. Effect of PLGA as a polymeric emulsifier on preparation of hydrophilic protein-loaded solid lipid nanoparticles，Colloids Surf B Biointerfaces. 2008 Dec 1; 67(2):199-204. Epub 2008 Aug 27.