郑世军 - 中国农业大学

个人简介

郑世军，免疫学博士，中国农业大学预防兽医系微生物与免疫学教授，国家杰出青年基金获得者，中国农业科学院教学名师，全国华侨侨眷先进个人。1982年考入北京农业大学兽医系学习（5年制），1987年毕业后师从甘孟侯教授攻读硕士学位，1990硕士毕业留校任教，讲授本科动物免疫学课程，1996年自费赴美国麻省大学（UMass）师从Dr.DA Freeman攻读博士学位，2000年博士毕业后前往宾夕法尼亚大学医学院在分子免疫学家Dr. Youhai Chen指导下深造。2005年夏，作为中国农业大学引进人才回到母校工作。目前主要从事抗感染免疫的分子机理以及畜禽传染病免疫防制的研究，主持科技部973及863课题、自然科学基金面上、重点及国家杰出青年基金项目、加拿大IDRC禽流感防治国际合作项目、转基因动物专项、现代农业产业体系岗位科学家项目等国家级项目和国际合作项目以及横向企业合作项目。主要研究成果以第一或共同第一作者或通讯作者的文章发表于Nature Immunology、J Clinical Investigation、F Immunology、J Immunology、Diabetes、J Biol Chem、J Virology、FCIM、Immunobiology、F Microbiol、IJMS、Vet Microbiol、Virus Research、Viruses、BBRC、Virology J、Arch of Virology、Poultry Sci等国际刊物，特约撰写的研究综述发表于Immunol Res、IJMS、Viruses等学术期刊，在国际核心期刊发表了60余篇研究论文，撰写《动物分子免疫学》个人专著(2015年第一版，2021年第二版)，主编或副主编专业书籍10部，参编专业书籍6部，译著3部，获得5项发明专利授权，研制出5种急需的家禽疫病检测试剂盒以及10余种家禽细胞因子ELISA检测试剂盒，尤其在禽免疫抑制病研究领域取得了突出原创性成果，揭示了传染性法氏囊病病毒(IBDV)的致病机理，受美国禽病专家马里兰大学SK Samal教授邀请参加国际知名专家共同撰写的禽病毒学专著《Avian Virology-Current Research and Future Trends》，独立撰写“IBDV Chapter”，扩大了我国禽病研究国际影响力。此外，在鸡白痢、呼肠孤病毒病、鸡传贫、腺病毒感染等研究领域都有原创性发现。担任中国农学会理事、动物传染病学分会常务理事、北京免疫学会理事、动物免疫学分会常务理事，第一届全国动物防疫专家委员会委员、第六届中国兽药典委员。担任国际期刊《Immunol and Immunobiotech》及《亚洲兽医病例研究》主编（EiC）、《中国兽医杂志》副主编以及多种国际和国内专业期刊编委。教育经历 2000年12月-2005年6月博士后，美国宾夕法尼亚大学 1996年8月-2000年12月博士，美国麻省大学 1987年9月-1990年7月硕士，中国农业大学 1982年9月-1987年7月学士，中国农业大学工作经历 2005年7月-至今中国农业大学动物医学院预防兽医学微生物与免疫学教授 2000年12月-2005年6月博士后，美国宾夕法尼亚大学 1996年8月-2000年12月研究助理，美国麻省大学 1993年1月-1996年8月讲师，中国农业大学 1990年7月-1993年1月助教，中国农业大学获奖及荣誉国家杰出青年基金获得者，获国务院特殊专家津贴，中国农科院教学名师，中国侨联-国务院侨办全国归侨侨眷先进个人

研究领域

主要研究领域包括：1）病原致病机理以及宿主抗感染免疫分子机制；2）新型疫苗与诊断试剂盒研制；3）动物疫病免疫防控以及种源性疫病净化

近期论文

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Zhou L, Hayrat A, Li J, Li XQ, Gao L, Cao H, Wang Y*, and Zheng SJ*. Gga-miR-30c-5p suppresses Avian Reovirus (ARV) Replication by inhibition of ARV-Induced Autophagy via Targeting ATG5. J Virology 2022，July 6, 96（14）：1-20. doi: 10.1128/jvi.00759-22 Hayrat A, Zhou L, Li J, Li W, Gao L, Cao H, Wang Y, Li X*, and Zheng SJ*. Gga-miR-30c-5p enhances apoptosis in fowl adenovirus serotype 4-infected leghorn male hepatocellular cells and facilitates viral replication through myeloid cell leukemia-1. Viruses 2022, 14, 990. https://doi.org/10.3390/v14050990. Li J, Hayrat A, Zhou L, Gao L, Chen J, Wang Y, Gao L, Cao H, Li XQ*, and Zheng SJ*. GATA3 inhibits viral infection by promoting the expression of MicroRNA-155. J Virology 2022, March, doi: 10.1128/jvi.01888-21. Zhou L, Li J, Hayrat A, Li XQ, Gao L, Cao H, Wang Y*, and Zheng SJ*. Gga-miR-29a-3p Suppresses Avian Reovirus-Induced Apoptosis and Viral Replication via Targeting Caspase-3. Vet Microbiology 2022，Jan;264:109294. doi: 10.1016/j.vetmic.2021.109294. Zhao D, Li J, Wang Y, Li X, Gao L, Cao H, and Zheng SJ*. Critical role for G3BP1 in infectious bursal disease virus (IBDV)-induced stress granule formation and viral replication. Vet Microbiology 2020, 248: 108806. doi.org/10.1016/j.vetmic.2020.108806. Duan X, Zhao M, Li X, Gao L, Cao H, Wang Y*, and Zheng SJ*. gga-miR-27b-3p Enhances Type I Interferon Expression and Suppresses Infectious Bursal Disease Virus Replication via Targeting Cellular Suppressors of Cytokine Signaling 3 and 6 (SOCS3 and 6). Virus Research 2020, Feb 29:197910. doi: 10.1016/j.virusres.2020.197910. PMID: 32126296 Duan X, Zhao M, Wang Y, Li X, Cao H, and Zheng SJ*. Epigenetic upregulation of chicken microRNA-16-5p expression in DF-1 cells following infection with Infectious Bursal Disease Virus (IBDV) enhances IBDV-induced apoptosis and viral replication. J Virology 2020, 94（2）. pii: e01724-19. doi: 10.1128/JVI.01724-19. Zhao M, Duan X, Wang Y, Gao L, Cao H, Li X*, and Zheng SJ*. A novel role for PX, a structural Protein of Fowl Adenovirus Serotype 4 (FAdV4), as an Apoptosis-inducer in Leghorn Male Hepatocellular Cells. Viruses 2020, Feb 18;12(2). pii: E228. doi: 10.3390/v12020228. Gao J, Zhao M, Duan X, Wang Y, Cao H, Li X* and Zheng SJ* Requirement of cellular protein CCT7 for the replication of fowl adenovirus serotype 4 (FAdV-4) in leghorn male hepatocellular cells via interaction with the viral hexon protein. Viruses 2019, 11, 107; doi:10.3390/v11020107. He Z, Chen X, Fu M, Tang J, Li X, Cao H, Wang Y*, and Zheng SJ*.Inhibition of fowl adenovirus serotype 4 replication in Leghorn male hepatoma cells by SP600125 via blocking JNK MAPK pathway. Vet Microbiology 2019, 228: 45-52. Gao J, Duan X, Li XQ, Cao H, Wang Y* and Zheng SJ* Emerging of A Highly Pathogenic and Multi-drug resistant Strain of Escherichia Coli Causing an outbreak of Colibacillosis in Chickens, Infection, Genetics and Evolution 2018, 65: 392-398. Fu M, Wang B, Chen X, He Z, Wang Y, Li X, Cao H, Zheng SJ*. gga-miR-454 suppresses infectious bursal disease virus (IBDV) replication via directly targeting IBDV genomic segment B and cellular Suppressors of Cytokine Signaling 6 (SOCS6). Virus Research 2018, July 2, 252: 29-40. Wang B, Fu M, Liu Y, Wang Y, Li X, Cao H, and Zheng SJ* gga-miR-155 Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANK. Front Cell Infect Microbiol 2018, March 7, 8(55); 1-13. Chen X, He Z, Fu M, Wang Y, Wu H, Li X, Cao H, and Zheng SJ * The E3 ubiquitin ligase Siah-1 suppresses avian reovirus infection by targeting p10 for degradation, J Virology 2018 , Jan 10. 92(6). pii: e02101-17. Wang B, Duan X, Fu M, Liu Y, Wang Y, Li X, Cao H, and Zheng SJ* The Association of Ribosomal Protein L18 (RPL18) with IBDV VP3 Enhances Viral Replication, Virus Research 2018, Feb 2;245:69-79. He Z, Chen X, Fu M, Tang J, Li X, Cao H, Wang Y, and Zheng SJ*. Infectious bursal disease virus protein VP4 suppresses, type I interferon expression via inhibiting K48-linked ubiquitylation of glucocorticoid-induced leucine zipper (GILZ), Immunobiology 2018, 223(4-5):374-382. Fu M, Wang B, Chen X, He Z, Wang Y, Li X, Cao H, and Zheng SJ*, gga-miR-130b suppresses infectious bursal disease virus replication via targeting the viral genome and cellular SOCS5, J Virology 2017 Dec 14;92(1). pii: e01646-17. doi: 10.1128/JVI.01646-17. Qin Y, Xu Z, Wang Y, Li X, Cao H, and Zheng SJ*, VP2 of Infectious Bursal Disease Virus induces apoptosis via triggering Oral Cancer Overexpressed 1 (ORAOV1) protein degradation. Frontiers in Microbiology 2017, July, 8(1): doi: 10.3389/fmicb.2017.01351 Li X, Liu Y, Wang Y, Liu J, Li XQ, Cao H, Gao X and Zheng SJ*, Negative regulation of hepatic inflammation by the Soluble Resistance-Related Calcium Binding Protein via STAT3. Frontier in Immunology 2017, June 29, 8: 1-14 Xu Z, Qin Y, Wang Y, Li X, Cao H, and Zheng SJ*, A Critical role of bacterioferritin in Salmonella pullorum-induced IFN-β expression in DF-1 cells, Frontiers in Microbiology 2016, 7(1): doi: 10.3389/fmicb.2016.00020 Wu H, H Z, Tang J, Li X, Cao H, Wang Y*, and Zheng SJ* A critical role of LAMP-1 in avian reovirus P10 degradation associated with inhibition of apoptosis and virus release. Arch Virol 2016, 161:899–911 Lin W, Zhang Z, Xu Z, Wang B, Li XQ, Cao H, Wang Y*, and Zheng SJ*. The Association of Receptor of Activated Protein Kinase C 1（RACK1）with Infectious Bursal Disease Virus Protein VP5 and VDAC2 Inhibits Apoptosis and Enhances Viral Replication. J Biol Chem. 2015, 290(13): 8500-10. Li X， Wang J，Liu J，Li Z， Wang Y，Xue Y, Li XQ, Cao H, and Zheng SJ*. Engagement of Soluble Resistance-Related Calcium Binding Protein (sorcin) with foot-and-mouth disease virus (FMDV) VP1 inhibits type I interferon response in cells, Vet Microbiology 2013，166: 35–46. Li Z, Wang Y, Li X, Li XQ, Cao H, and Zheng SJ*. Critical Roles of Glucocorticoid-Induced Leucine Zipper in Infectious Bursal Disease Virus (IBDV)-induced Suppression of Type I Interferon Expression and Enhancement of IBDV Growth in Host Cells via Interaction with VP4. Journal of Virology 2013, 87(2):1221-1231. Li X, Li XQ, Cao H, Wang Y, and Zheng SJ*. Engagement of new castle disease virus (NDV) matrix (M) protein with charged multivesicular body protein (CHMP) 4 facilitates viral replication. Virus Research 2013, 171: 80-88. Wang J, Wang Y, Liu J, Ding L, Zhang Q, Li X, Cao H, Tang J, and Zheng SJ*. A critical role of N-myc and STAT interactor (Nmi) in foot-and-mouth disease virus (FMDV) 2C-induced apoptosis. Virus Research 2012, 170 (2012) 59– 65. Luo Z, Li Z, Chen K, Liu R, Li X, Cao H, and Zheng SJ*. Engagement of Heterogeneous Nuclear Ribonucleoprotein M with Listeriolysin O Induces Type I Interferon Expression and Restricts Listeria Monocytogenes Growth in Host Cells. Immunobiology 2012, 217(10): 972-981. Li Z, Wang Y, Xue Y, Li X, Cao H, and Zheng SJ*. A critical role for voltage-dependent anion channel (VDAC) 2 in infectious bursal disease virus (IBDV)-induced apoptosis in host cells via interacting with VP5. Journal of Virology 2012, 86(3): 1328-1338. Li H, Wang Y, Ding L, and Zheng SJ*. Staphylococcus sciuri exfoliative toxin C (ExhC) is a necrosis-inducer for mammalian cells. PLoS ONE 2011, 6 (7): e23145: 1-9. Chen K, Luo Z, Tang J, Zheng SJ*. A critical role of heat shock cognate protein 70 in Apoptin-induced phosphorylation of Akt. Biochem Biophys Res Commun. 2011 Jun 3; 409(2):200-4. Wang Y, Lu Y, Duo Y, Wang Y,Chen F,Yang H, Zheng SJ*. Enhanced resistance of restraint stressed mice to sepsis. Journal of Immunology 2008, 181:3441-3448. Chen S, Wang Y, Chen F, Yang H, Gan M, and Zheng SJ*. A highly pathogenic strain of Staphylococcus sciuri caused fatal exudative epidermitis in piglets. PLoS ONE 2007, 2(1)e147: 1-6. Zheng SJ, L-Cherradi S, Wang P, Xu LY and Chen YH. Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes 2005, 54: 1423-1428. Zheng SJ, Jiang J., Shen H., and Chen YH. Reduced apoptosis and listeriosis in TRAIL-null mice. Journal of Immunology 2004, 173: 5652-5658. Zheng SJ, Wang P., Tsabary G. and Chen YH. Critical role of TRAIL in hepatic cell death and hepatic inflammation. Journal of Clinical Investigation 2004, 113(1): 58-64. L-Cherridi S*, Zheng SJ*(*Co-first author), Maguaschak, KA and Chen YH. Defective thymocyte apoptosis and accelerated autoimmunune diseases in TRAIL-Null mice. Nature Immunology 2003, 4(3): 255-260. *Note: The first two authors contributed equally to this study. Invited Reviews Zhang S and Zheng SJ*. Host Combats IBDV Infection at Both Protein and RNA Levels. Viruses 2022, 14, 2309. https://doi.org/ 10.3390/v14102309. (Invited review) Li W, Wang H, and Zheng SJ*. Roles of RNA Sensors in Host Innate Response to Influenza Virus and Coronavirus Infections. IJMS 2022, 23, 8285. https://doi.org/10.3390/ijms23158285. (Invited review) Wang H, Li W and Zheng SJ*. Advances on innate immune evasion by avian immunosuppressive viruses. Front. Immunol. 2022, May 12, 13:901913. doi: 10.3389/ fimmu.2022.901913. (Invited review) Li J and Zheng SJ*. Role of microRNAs in host defense against infectious bursal disease virus (IBDV) infection: a hidden front line. Viruses 2020, May 14, 12(543): 1-18. doi:10.3390/v12050543. (Invited review) Zhou L and Zheng SJ* The roles of microRNAs(miRNAs) in avian response to viral infection and pathogenesis of avian immunosuppressive diseases. IJMS 2019, Nov 1;20(21). pii: E5454. doi: 10.3390/ijms20215454. (Invited review) Qin Y and Zheng SJ* .Infectious Bursal Disease Virus-Host Interactions: Multifunctional Viral Proteins that Perform Multiple and Differing Jobs. International J of Molecular Sciences 2017, 18, 161; doi:10.3390/ijms18010161. (Invited review) Zheng SJ and Chen YH. TRAIL, Bim and thymic negative selection. Immunological Research 2003, 28/3: 293-299. 近年代表性论著 Zheng SJ*，Veterinary Molecular Immunology, an English version of 《动物分子免疫学》第2版, translated and published by Springer Nature Press, （currently in press）. Zheng SJ*, Chapter 7: Infectious Bursal Disease Virus for the Book “Avian Virology-Current Research and Future Trends” published by Caister Academic Press, November of 2019. 郑世军著《动物分子免疫学》2015年9月，33.5万字,中国农业出版社（“十二五”国家重点图书出版项目）2017年12月第二次印刷。郑世军、宋清明主编《现代动物传染病学》2013年12月，144.5万字,中国农业出版社。(获国家出版基金项目资助) 郑世军著《动物分子免疫学》第2版，2021年9月，55.5万字,ISBN 978-7-109-28131-8，中国农业出版社（现代兽医基础研究经典著作，国家出版基金项目资助）。