索勋 - 中国农业大学

个人简介

教育经历 1980年~1986年：本科北京农业大学兽医学专业 1986年~1989年：硕士北京农业大学预防兽医学专业工作经历 1989年~1991年：助教北京农业大学动物医学院 1991年~1998年：讲师北京农业大学/中国农业大学动物医学院 1998年~2003年：副教授中国农业大学动物医学院 2003年~至今：教授中国农业大学动物医学院 2011年~2012年：访问学者宾夕法尼亚大学医学院获奖及荣誉 2000年至2002年新世纪人才工程优秀青年骨干教师、2001年度校级优秀教师、2003年校杰出教师、2004年校级师德标兵、2004年北京市优秀教师、2004年全国优秀教师。2000年获中国农业大学青年教师基本功比赛二等奖，2003年参讲的“兽医寄生虫学”被教育部评为国家精品课程，2003年“高级寄生虫学”被校研究生院评为名牌课程，主讲的“兽医寄生虫学”网络课程于2009年被教育部评为国家精品课程，主持的“兽医寄生虫学网络课程建设”于2013年获北京市教学成果二等奖，领导的“兽医寄生虫学”现代远程教育课程教学团队于2013年获北京市继续教育优秀教学团队，主讲的“兽医寄生虫学”网络课程于2016年被教育部授予为“国家精品资源共享课”称号。参加的科研项目曾分别荣获1998年教育部科技进步奖二等奖、1999年河南省教育委员会科技进步二等奖；论文《柔嫩艾美耳球虫球虫球虫晚熟系选育与生物学特性研究》于1997年获北京市科协优秀科技论文一等奖

研究领域

主要从事寄生虫免疫学和遗传学的研究。首次提出利用艾美耳属球虫作为疫苗载体的假设，已取得重大进展，获得国内外学术界高度认可。成功开发出基于致弱球虫虫株的鸡球虫病活卵囊疫苗并进行了成果转化。利用弱毒兔球虫开发的兔球虫病活疫苗已完成了实验室制备和中间试制生产，正在申报新兽药注册证书。寄生虫遗传学方面，利用实验室进化和重测序等技术，结合实验室建立的球虫遗传操作及基因编辑平台，揭示球虫早熟及抗药性产生的遗传基础

近期论文

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Wang S, Suo X. Still na?ve or primed: Anticoccidial vaccines call for memory. Exp Parasitol. 2020. doi: 10.1016/j.exppara. Tang X, Liu X, Suo X. Towards Innovative Design and Application of Recombinant Eimeria as a Vaccine Vector. Infect Immun. 2020. doi: 10.1128/IAI.00861-19. Invited review. Tang X, Suo J, Liang L, Duan C, Hu D, Gu X, Yu Y, Liu X, Cui S, Suo X. Genetic modification of the protozoan Eimeria tenella using the CRISPR/Cas9 system. Vet Res. 2020. doi: 10.1186/s13567-020-00766-0. Fang S, Gu X, El-Ashram S, Li X, Yu X, Guo B, Li H, Liu N, Liu X, Cui P, Suo X. Immune protection provided by a precocious line trivalent vaccine against rabbit Eimeria. Vet Parasitol. 2019. doi: 10.1016/j.vetpar. Huang WY, Wang M, Suo X, Lun ZR, Zhu XQ. How is veterinary parasitology taught in China? Trends Parasitol. 2006. doi: 10.1016/j.pt.2006.09.009. Liu GH, Zhang LX, Zou FC, Yuan ZG, Zhao GH, Hu M, Suo X, Zhu XQ. Veterinary parasitology teaching in China in the 21st century - Challenges, opportunities and perspectives. Vet Parasitol. 2018. doi: 10.1016/j.vetpar. Li Z, Guo Q, Zheng L, Ji Y, Xie YT, Lai DH, Lun ZR, Suo X, Gao N. Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii. Cell Res. 2017. doi: 10.1038/cr.2017.104. Kong P, Ufermann CM, Zimmermann DLM, Yin Q, Suo X, Helms JB, Brouwers JF, Gupta N. Two phylogenetically and compartmentally distinct CDP-diacylglycerol synthases cooperate for lipid biogenesis in Toxoplasma gondii. J Biol Chem. 2017. doi: 10.1074/jbc. Tang X, Liu X, Tao G, Qin M, Yin G, Suo J, Suo X. "Self-cleaving" 2A peptide from porcine teschovirus-1 mediates cleavage of dual fluorescent proteins in transgenic Eimeria tenella. Vet Res. 2016. doi: 10.1186/s13567-016-0351-z. Tang X, Suo J, Li C, Du M, Wang C, Hu D, Duan C, Lyu Y, Liu X, Suo X. Transgenic Eimeria tenella Expressing Profilin of Eimeria maxima Elicits Enhanced Protective Immunity and Alters Gut Microbiome of Chickens. Infect Immun. 2018. doi: 10.1128/IAI.00888-17. Zou J, Liu X, Shi T, Huang X, Wang H, Hao L, Yin G, Suo X. Transfection of Eimeria and Toxoplasma using heterologous regulatory sequences. Int J Parasitol. 2009. doi: 10.1016/j.ijpara. Yin G, Liu X, Zou J, Huang X, Suo X. Co-expression of reporter genes in the widespread pathogen Eimeria tenella using a double-cassette expression vector strategy. Int J Parasitol. 2011. doi: 10.1016/j.ijpara. Hao L, Liu X, Zhou X, Li J, Suo X. Transient transfection of Eimeria tenella using yellow or red fluorescent protein as a marker. Mol Biochem Parasitol. 2007. doi: 10.1016/j.molbiopara. Yan W, Liu X, Shi T, Hao L, Tomley FM, Suo X. Stable transfection of Eimeria tenella: constitutive expression of the YFP-YFP molecule throughout the life cycle. Int J Parasitol. 2009. doi: 10.1016/j.ijpara. Huang X, Zou J, Xu H, Ding Y, Yin G, Liu X, Suo X. Transgenic Eimeria tenella expressing enhanced yellow fluorescent protein targeted to different cellular compartments stimulated dichotomic immune responses in chickens. J Immunol. 2011. doi: 10.4049/jimmunol. Chapman HD, Barta JR, Blake D, Gruber A, Jenkins M, Smith NC, Suo X, Tomley FM. A selective review of advances in coccidiosis research. Adv Parasitol. 2013. doi: 10.1016/B978-0-12-407705-8.00002-1. Liu X, Shi T, Ren H, Su H, Yan W, Suo X. Restriction enzyme-mediated transfection improved transfection efficiency in vitro in Apicomplexan parasite Eimeria tenella. Mol Biochem Parasitol. 2008. doi: 10.1016/j.molbiopara. Dong X, Abdelnabi GH, Lee SH, Li G, Jin H, Lillehoj HS, Suo X. Enhanced egress of intracellular Eimeria tenella sporozoites by splenic lymphocytes from coccidian-infected chickens. Infect Immun. 2011. doi: 10.1128/IAI.01334-10. Sun XM, Ji YS, Elashram SA, Lu ZM, Liu XY, Suo X, Chen QJ, Wang H. Identification of antigenic proteins of Toxoplasma gondii RH strain recognized by human immunoglobulin G using immunoproteomics. J Proteomics. 2012. doi: 10.1016/j.jprot. Liu X, Zou J, Yin G, Su H, Huang X, Li J, Xie L, Cao Y, Cui Y, Suo X.Development of transgenic lines of Eimeria tenella expressing M2e-enhanced yellow fluorescent protein (M2e-EYFP). Vet Parasitol. 2013. doi: 10.1016/j.vetpar.