杨汉春 - 中国农业大学

个人简介

教育经历 1979.09-1983.07 四川农业大学兽医本科 1983.09-1986.07 南京农业大学兽医微生物学与免疫学硕士研究生 1988.09-1992.07 中国农业大学兽医寄生虫学与寄生虫病学博士研究生工作经历 1986.07-1988.07 中国农业大学动物医学院助教 1988.07-1992.01 中国农业大学动物医学院讲师 1992.01-1997.12 中国农业大学动物医学院副教授 1997.12-迄今中国农业大学动物医学院教授，曾任预防兽医学系主任、动物医学院副院长 1994.08-1994.11 以色列希伯莱大学访问学者 2000.07-2001.04 美国马里兰大学访问教授获奖及荣誉国家科学技术进步二等奖1项（排名第四）（2021）主编的《动物免疫学》获首届全国教材建设奖—全国优秀教材（高等教育类）二等奖（2021）国家有突出贡献的中青年专家国家杰出青年基金全国农业科研杰出人才北京市教学名师宝钢教育基金会优秀教师奖全国优秀科技工作者

研究领域

动物分子病毒学与免疫学；猪繁殖与呼吸综合征等猪病毒性疫病的分子病原学与分子流行病学、诊断与防治技术、致病与免疫机制

近期论文

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Li H, Yang H*. Infection of porcine reproductive and respiratory syndrome virus suppresses the antibody response to classical swine fever virus vaccination. 2003. Veterinary Microbiology, 2003, 95 (4): 295-301. Gao Z, Guo X, Yang H*. Genomic characterization of two Chinese isolates of porcine respiratory and reproductive syndrome virus. Archives of Virology, 2004, 149 (7): 1341-1351. Yang H, Chen S, White DG, Zhao S, McDermott P, Walker R, Meng J*. Characterization of multiple-antimicrobial-resistant Escherichia coli isolates from diseased chickens and swine in China. Journal of Clinical Microbiology 2004, 42 (8): 3483–3489. Wen L, Guo X, Yang H*. Genotyping of porcine circovirus type 2 from a variety of clinical conditions in China. Veterinary Microbiology, 2005, 110 (1-2): 141-146. Yan Y, Guo X, Ge X, Chen Y, Cha Z, Yang H*. Monoclonal antibody and porcine antisera recognized B-cell epitopes of Nsp2 protein of a Chinese strain of porcine reproductive and respiratory syndrome virus. Virus Research, 2007, 126 (1-2): 207-215. Shi K, Li H, Guo X, Ge X, Jia H, Zheng S, Yang H*. Changes in peripheral blood leukocyte subpopulations in piglets co-infected experimentally with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2. Veterinary Microbiology, 2008, 129 (3-4): 367-377. Ran Z, Chen X, Guo X, Ge X, Yoon KJ*, Yang H*. Recovery of viable porcine reproductive and respiratory syndrome virus from an infectious clone containing partial deletion within Nsp2-encoding region. Archives of Virology, 2008, 153 (5): 899-907. Zhou L, Zhang J, Zeng J, Yin S, Li Y, Zheng L, Guo X, Ge X, Yang H*. The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence. Journal of Virology, 2009, 83 (10): 5156-5167. Zhang H, Guo X, Ge X, Chen Y, Sun Q, Yang H*. Changes in the cellular proteins of pulmonary alveolar macrophage infected with porcine reproductive and respiratory syndrome virus by proteomics analysis. Journal of Proteome Research, 2009, 8 (6): 3091-3097. Zhou L, Chen S, Zhang J, Zeng J, Guo X, Ge X, Zhang D, Yang H*. Molecular variation analysis of porcine reproductive and respiratory syndrome virus in China. Virus Research, 2009, 145 (1): 97-105. Zhou L, Yang H*. Porcine reproductive and respiratory syndrome in China. Virus Research, 2010, 154 (1-2): 31-37. Shi K, Guo X, Ge X, Liu Q, Yang H*. Cytokine mRNA expression profiles in peripheral blood mononuclear cells from piglets experimentally co-infected with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2. Veterinary Microbiology, 2010, 140 (1-2): 155-160. Zhang Y, Li Z, Ge X, Gou X, Yang H*. Autophagy promotes the replication of encephalomyocarditis virus in host cells. Autophagy, 2011, 7 (6): 613-628. Liu D, Zhou R, Zhang J, Zhou L, Jiang Q, Guo X, Ge X, Yang H*. Recombination analyses between two strains of porcine reproductive and respiratory syndrome virus in vivo. Virus Research, 2011, 155 (2): 473-486. Liu Q, Qin Y, Zhou L, Kou Q, Guo X, Ge X, Yang H*, Hu H*. Autophagy sustains the replication of porcine reproductive and respiratory virus in host cells. Virology, 2012, 429 (2):136-147. Ge X, Wang F, Guo X, Yang H*. Porcine circovirus type 2 and its associated diseases in China. Virus Research, 2012, 164 (1-2): 100-106. Gao Y, Kou Q, Ge X, Zhou L, Guo X, Yang H*. Phylogenetic analysis of porcine epidemic diarrhea virus field strains prevailing recently in China. Archives of Virology, 2012, 158(3):711-715. Li Y, Zhou L, Zhang J, Ge X, Zhou R, Zheng H, Geng G, Guo X, Yang H*. Nsp9 and nsp10 contribute to the fatal virulence of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China. PLoS Pathogens, 2014, 10 (7): e1004216. Han D, Hu Y, Li L, Tian H, Chen Z, Wang L, Ma H, Yang H*, Teng K*. Highly pathogenic porcine reproductive and respiratory syndrome virus infection results in acute lung injury of the infected pigs. Veterinary Microbiology, 2014, 169 (3-4): 135-146. Gu W, Zeng N, Zhou L, Ge X, Guo X, Yang H*. Genomic organization and molecular characterization of porcine cytomegalovirus. Virology. 2014, 460-461: 165-72. Wang X, Li C, Zhou L, Zhang N, Wang X, Ge X, Guo X, Yang H*. 2014. Porcine reproductive and respiratory syndrome virus counteracts the porcine intrinsic virus restriction factors-IFITM1 and Tetherin in MARC-145 cells. Virus Research, 2014, 191: 92-100. He Q, Li Y, Zhou L, Ge X, Guo X*, Yang H*. Both Nsp1 β and Nsp11 are responsible for differential TNF-a production induced by porcine reproductive and respiratory syndrome virus strains with different pathogenicity in vitro. Virus Research, 2015, 201: 32-40. Zhou L, Wang Z, Ding Y, Ge X, Guo X, Yang H*. NADC30-like Strain of Porcine Reproductive and Respiratory Syndrome Virus, China. Emerging Infectious Diseases, 2015, 21 (12): 2256-2257. Zhao S, Ge X, Wang X, Liu A, Guo X, Zhou L, Yu K, Yang H*. The DEAD-box RNA helicase 5 positively regulates the replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp9 in vitro. Virus Research, 2015, 195: 217-224. Du J, Ge X, Liu Y, Jiang P, Wang Z, Zhang R, Zhou L, Guo X, Han J*, Yang H*. Targeting swine leukocyte antigen class I molecules for proteasomal degradation by the nsp1a replicase protein of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus strain JXwn06. Journal of Virology, 2016, 90 (2): 682-693. Zhang L, Zhou L, Ge X, Guo X, Han J, Yang H*. The Chinese highly pathogenic porcine reproductive and respiratory syndrome virus infection suppresses Th17 cells response in vivo. Veterinary Microbiology, 2016, 189, 75–85. Han J, Zhou L, Ge X, Guo X, Yang H*. Pathogenesis and control of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus. Veterinary Microbiology, 2017, 209: 30-47. Zhou L, Yang B, Xu L, Jin H, Ge X, Guo X, Han J, Yang H*. Efficacy evaluation of three modified-live virus vaccines against a strain of porcine reproductive and respiratory syndrome virus NADC30-like. Veterinary Microbiology, 2017, 207: 108-116. Bian T, Sun Y, Hao M, Zhou L, Ge X, Guo X, Han J, Yang H*. A recombinant type 2 porcine reproductive and respiratory syndrome virus between NADC30-like and a MLV-like: Genetic characterization and pathogenicity for piglets. Infection, Genetics and Evolution, 2017, 54: 279-286. Xu L, Zhou L, Sun W, Zhang P, Ge X, Guo X, Han J, Yang H*. Nonstructural protein 9 residues 586 and 592 are critical sites in determining the replication efficiency and fatal virulence of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus. Virology, 2018, 517: 135-147. Dong H, Zhou L, Ge X, Guo X, Han J, Yang H*. Porcine reproductive and respiratory syndrome virus nsp1β and nsp11 antagonize the antiviral activity of cholesterol-25-hydroxylase via lysosomal degradation. Veterinary Microbiology, 2018, 223:134-143. Wang D, Ge X, Chen D, Li J, Cai Y, Deng J, Zhou L, Guo X, Han J*, Yang H*. The S gene is necessary but not sufficient for the virulence of porcine epidemic diarrhea virus novel variant strain BJ2011C. Journal of Virology, 2018, 92(13):e00603-18. Zhang Z, Zhou L, Ge X, Guo X, Han J, Yang H*. Evolutionary analysis of six isolates of porcine reproductive and respiratory syndrome virus from a single pig farm: MLV-evolved and recombinant viruses. Infection, Genetics and Evolution, 2018, 66: 111-119. Zhou X, Zhou L, Ge X, Guo X, Han J, Zhang Y*, Yang H*. Quantitative proteomic analysis of porcine intestinal epithelial cells infected with porcine deltacoronavirus using iTRAQ-coupled LC-MS/MS. Journal of Proteome Research, 2020, 19(11):4470-4485. Ren J, Wang H, Zhou L, Ge X, Guo X, Han J*, Yang H*. Glycoproteins C and D of PRV strain HB1201 contribute individually to the escape from Bartha-K61 vaccine-induced immunity. Frontiers in Microbiology, 2020,11: 323. Zhou X, Zhou L, Zhang P, Ge X, Guo X, Han J, Zhang Y*, Yang H*. A strain of porcine deltacoronavirus: Genomic characterization, pathogenicity and its full-length cDNA infectious clone. Transboundary and Emerging Diseases, 2021, 68(4):2130-2146. Zhou L, Ge X, Yang H*. Porcine reproductive and respiratory syndrome modified live virus vaccine: a "leaky" vaccine with debatable efficacy and safety. Vaccines, 2021, 9(4): 362. Zhou X, Ge X, Zhang Y, Han J, Guo X, Chen Y, Zhou L*, Yang H*. Attenuation of porcine deltacoronavirus disease severity by porcine reproductive and respiratory syndrome virus coinfection in a weaning pig model. Virulence, 2021, 12 (1):1011-1021. Wen X, Ge X, Zhou L, Zhang Y*, Guo X, Yang H*. PRRSV Promotes MARC-145 cells entry into S phase of the cell cycle to facilitate viral replication via degradation of p21 by nsp11. Frontiers in Veterinary Sciences, 2021, 8:642095. 杨汉春，周磊. 猪繁殖与呼吸综合征病毒的遗传变异与演化. 生命科学, 2016, 28 (3): 325-336.