近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
Liang Chen, Shun Zhang, Niannian Xue, Mengjia Hong, Xiaohui Zhang, Dan Zhang, Jing Yang, Sijia Bai, Yifan Huang, Haowei Meng, Hao Wu, Changming Luan, Biyun Zhu, Gaomeng Ru, Hongyi Gao, Liping Zhong, Meizhen Liu, Mingyao Liu, Yiyun Cheng, Chengqi Yi, Liren Wang, Yongxiang Zhao*, Gaojie Song*, Dali Li*. Engineering precise adenine base editor with minimal bystander editing. Nat Chem Biol. In press 2022.
Zhang J*, Hu Y, Yang J, Li W, Zhang M, Wang Q, Zhang L, Wei G, Tian Y, Zhao K, Chen A, Tan B, Cui J, Li D, Li Y, Qi Y, Wang D, Wu Y, Li D*, Du B*, Liu M*, Huang H*. Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL. Nature. 2022 Sep;609(7926):369-374.
Fu B*, Liao J, Chen S, Li W, Wang Q, Hu J, Yang F, Hsiao S, Jiang Y, Wang L, Chen F, Zhang Y, Wang X, Li D*, Liu M*, Wu Y*. CRISPR-Cas9-mediated gene editing of the BCL11A enhancer for pediatric β0/β0 transfusion-dependent β-thalassemia. Nat Med. 2022 Aug;28(8):1573-1580.
Chen X, Niu X, Liu Y, Zheng R, Yang L, Lu J, Yin S, Wei Y, Pan J, Sayed A, Ma X, Liu M, Jing F, Liu M, Hu J*, Wang L*, Li D*. Long-term correction of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration. J Genet Genomics. 2022 Jun 9:S1673-8527(22)00159-X
Li Y, Wang D, Ping X, Zhang Y, Zhang T, Wang L, Jin L, Zhao W, Guo M, Shen F, Meng M, Chen X, Zheng Y, Wang J, Li D, Zhang Q, Hu C, Xu L, Ma X. Local hyperthermia therapy induces browning of white fat and treats obesity. Cell. 2022 Mar 17;185(6):949-966.
Wang W, Zhao X, Shao Y, Duan X, Wang Y, Li J, Li J, Li D, Li X, Wong J. Mutation-induced DNMT1 cleavage drives neurodegenerative disease. Sci Adv. 2021 Sep 3;7(36):eabe8511. doi: 10.1126/sciadv.abe8511.
Liang Y, Zhang X, Liu Y, Wang L, Ye Y, Tan X, Pu J, Zhang Q, Bao X, Wei X, Li D, Kurita R, Nakamura Y, Li D, Xu X. GATA zinc finger domain-containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with β-thalassaemia through impaired formation of methyl-binding domain protein 2 (MBD2)-containing nucleosome remodelling and deacetylation (NuRD) complex. Br J Haematol. 2021 Jun;193(6):1220-1227. doi: 10.1111/bjh.17511.
Zeng ZY, Lu JW, Cao XY, Wang XY, Li DL*. A method for constructing GLP-1 overexpression intestinal organoids.
Zhang L, Ge JY, Zheng YW*, Sun Z, Wang C, Peng Z, Wu B, Fang M, Furuya K, Ma X, Shao Y, Ohkohchi N, Oda T, Fan J, Pan G, Li D*, Hui L*. Survival-Assured Liver Injury Preconditioning (SALIC) Enables Robust Expansion of Human Hepatocytes in Fah-/- Rag2-/- IL2rg-/- Rats. Adv Sci (Weinh). 2021 Aug 11:e2101188. doi: 10.1002/advs.202101188.
Li X, Zheng M, Xu B, Li D, Shen Y, Nie Y, Ma L, Wu J. Generation of offspring-producing 3D ovarian organoids derived from female germline stem cells and their application in toxicological detection. Biomaterials. 2021 Dec;279:121213.
Wang L, Aschenbrenner D, Zeng Z, Cao X, Mayr D, Mehta M, […] Huang Y*, Li D*, Uhlig HH, Muise AM*. Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice.Nat Genet. 2021 Mar 29. doi: 10.1038/s41588-021-00803-4. (Highlighted by News & Views: The sickening consequences of too much SYK signaling. Nat Genet. 2021 Mar 29.
Li Y, Zheng R, Xu G, Huang Y, Li Y, Li D*, Geng H*. Generation and characterization of a novel rat model of primary hyperoxaluria type 1 with a nonsense mutation in alanine-glyoxylate aminotransferase. Am J Physiol Renal Physiol. 2021 Mar 1;320(3):F475-F484.
Bao X, Zhang X, Wang L, Wang Z, Huang J, Zhang Q, Ye Y, Liu Y, Chen D, Zuo Y, Liu Q, Xu P, Huang B, Fang J, Lao J, Feng X, Li Y, Kurita R, Nakamura Y, Yu W, Ju C, Huang C, Mohandas N, Li D, Zhao C, Xu X. Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia. Am J Hum Genet. 2021 Apr 1;108(4):709-721.
Zhang S, Shen J, Li D, Cheng Y. Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing. Theranostics. 2021 Jan 1;11(2):614-648.
Li H, Zhang Q, Gu Y, Wu Y, Wang Y, Wang L, Feng S, Hu Y, Zheng Y, Li Y, Ye H, Zhou B, Lin L, Liu M*, Yang H* and Li D*. Efficient photoactivatable Dre recombinase for cell type specific spatiotemporal control of genome engineering in the mouse. Proc. Natl. Acad. Sci. U.S.A.. 2020 Dec 29;117(52):33426-33435.
Zheng R, Fang X, Chen X, Huang Y, Xu G, He L, Li Y, Niu X, Yang L, Wang L, Li D*, Geng H. Knockdown of lactate dehydrogenase by adeno-associated virus-delivered CRISPR/Cas9 system alleviates primary hyperoxaluria type 1. Clin Transl Med. 2020 Dec;10(8):e261.
Zhang X, Zhu B, Chen L, Xie L, Yu W, Wang Y, Li L, Yin S, Yang L, Hu H, Han H, Li Y, Wang L, Chen G, Ma X, Geng H, Huang W, Pang X, Yang Z, Wu Y, Siwko S, Kurita R, Nakamura Y, Yang L, Liu M, Li D.*. Dual Base Editor Catalyzes Both Cytosine and Adenine Base Conversions in Human Cells. Nat Biotechnol. 2020 Jun 1. doi: 10.1038/s41587-020-0527-y.
Zhang X, Chen L, Zhu B, Wang L, Chen C, Hong M, Huang Y, Li H, Han H, Cai B, Yu W, Yin S, Yang L, Yang Z, Liu M, Zhang Y, Mao Z, Wu Y, Liu M, Li D*. Increasing efficiency and targeting scope of base editors through fusion of a single strand DNA binding protein domain. Nat Cell Biol. 2020 May 11. doi: 10.1038/s41556-020-0518-8.
Yang L, Wang L, Huo Y, Chen X, Yin S, Hu Y, Zhang X, Zheng R, Geng H, Han H, Ma X, Liu M, Li H, Yu W, Liu M, Wang J, Li D*.Amelioration of an Inherited Metabolic Liver Disease Through Creation of a De Novo Start Codon by Cytidine Base Editing. Mol Ther. 2020 May 7;S1525-0016(20)30235-5
Yin S, Ma L, Shao T, Zhang M, Guan Y, Wang L, Hu Y, Chen X, Han H, Shen N, Qiu W, Geng H, Yu Y, Li S, Yu W, Liu M, Li D*. Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor. Sci China Life Sci. 2020 Aug 17. doi: 10.1007/s11427-020-1744-6.
Wei G, Gao N, Chen J, Fan L, Zeng Z, Gao G, Li L, Fang G, Hu K, Pang X, Fan HY, Clevers H, Liu M, Zhang X*, Li D*. ERK/MAPK signaling is essential for intestinal development through Wnt pathway modulation. Development. 2020 Aug 3:dev.185678.
Li L, Mi D, Pei H, Duan Q, Wang X, Zhou W, Jin J, Li D, Liu M, Chen Y. In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15. Signal Transduct Target Ther. 2020 Jul 27;5(1):129.
Wang L, Li L, Ma Y, Hu H, Li Q, Yang Y, Liu W, Yin S, Li W, Fu B, Kurita R, Nakamura Y, Liu M*, Lai Y*, Li D.*. Reactivation of γ-globin Expression through Cas9 or Base Editor to Treat β-Hemoglobinopathies. Cell Research 2020 30(3):276-278
Zheng R, Li Y, Wang L, Fang X, Zhang J, He L, Yang L, Li D*, Geng H*. CRISPR/Cas9-mediated metabolic pathway reprogramming in a novel humanized rat model ameliorates primary hyperoxaluria type 1. Kidney Int. 2020 May 25:S0085-2538(20)30554-8.
UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/β-catenin signaling. Li L, Duan Q, Zeng Z, Zhao J, Lu J, Sun J, Zhang J, Siwko S, Wong J, Shi T, Zhang X, Liu M*, Chen J*, Li D.* Int J Cancer. 2020 May 6. doi: 10.1002/ijc.33036
Li Q, Zhou L, Wang L, Li S, Xu G, Gu H, Li D, Liu M, Fang L, Wang Z, Han S, Zheng B. Bcl6 modulates innate immunity by controlling macrophage activity and plays critical role in experimental autoimmune encephalomyelitis. Eur J Immunol. 2020 Apr;50(4):525-536.
Wan H, Wang Q, Chen X, Zeng Q, Shao Y, Fang H, Liao X, Li HS, Liu MG, Xu TL, Diao M, Li D, Meng B, Tang B, Zhang Z, Liao L. WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death. Autophagy. 2020 Mar;16(3):531-547.
Li J, Wang R, Jin J, Han M, Chen Z, Gao Y, Hu X, Zhu H, Gao H, Lu K, Shao Y, Lyu C, Lai W, Li P, Hu G, Li J, Li D, Wang H, Wu Q, Wong J. USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment. Cell Discov. 2020 Aug 24;6:58.
Yu Y, Wu X, Guan N, Shao J, Li H, Chen Y, Ping Y, Li D, Ye H. Engineering a far-red light-activated split-Cas9 system for remote-controlled genome editing of internal organs and tumors. Sci Adv. 2020 Jul 10;6(28):eabb1777.
Zhang X, Zhang H, Xu C, Li X, Li M, Wu X, Pu W, Zhou B, Wang H, Li D, Ding Q, Ying H, Wang H, Zhang H.Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.Nat Commun. 2019 Sep 13;10(1):4158.
Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Yi J, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng J. SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. Mol Cell. 2019 Jun 25. pii: S1097-2765(19)30441-1.
Luan P, Jian W, Xu X, Kou W, Yu Q, Hu H, Li D, Wang W, Feinberg MW, Zhuang J, Xu Y, Peng W. NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ. Nat Commun. 2019 Jun 28;10(1):2882.
Wan H, Wang Q, Chen X, Zeng Q, Shao Y, Fang H, Liao X, Li HS, Liu MG, Xu TL, Diao M, Li D, Meng B, Tang B, Zhang Z, Liao L. WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death. Autophagy. 2019 Jun 23:1-17.
Zheng R, Fang X, He L, Shao Y, Guo N, Wang L, Liu M, Li D*, Geng H*. Generation of a primary hyperoxaluria type 1 disease model via CRISPR/Cas9 system in rats. Curr Mol Med. 2018 Dec 11.
Zhang YL, Zhao LW, Zhang J, Le R, Ji SY, Chen C, Gao Y, Li D, Gao S, Fan HY. DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. EMBO J. 2018 Sep 14;37(18).
Yang L, Zhang X, Wang L, Yin S, Zhu B, Xie L, Duan Q, Hu H, Zheng R, Wei Y, Peng L, Han H, Zhang J, Qiu W, Geng H, Siwko S, Zhang X, Liu M, Li D*. Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants. Protein Cell. 2018 Sep;9(9):814-819. (Cover story, Highlight by Protein & Cell Volume 9, Issue 9, pp 752–753)
Shao Y, Wang L, Guo N, Wang S, Yang L, Li Y, Wang M, Yin S, Han H, Zeng L, Zhang L, Hui L, Ding Q, Zhang J, Geng H, Liu M*,Li D*. Cas9-nickase-mediated genome editing corrects hereditary tyrosinemia in rats. J Biol Chem. 2018, 293(18):6883-6892
Zhao Y, Yang Y, Xing R, Cui X, Xiao Y, Xie L, You P, Wang T, Zeng L, Peng W, Li D*, Chen H*, Liu M*. Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats. Atherosclerosis. 2018, 271:26-35.
Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D*, Yu X*, Sun JP*. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility. Elife. 2018 Feb 2;7. pii: e33432
Wen H, Ma H, Cai Q, Lin S, Lei X, He B, Wu S, Wang Z, Gao Y, Liu W, Liu W, Tao Q, Long Z, Yan M, Li D, Kelley KW, Yang Y, Huang H, Liu Q. Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma. Nat Med. 2018 Jan 1. doi: 10.1038/nm.4456.
Yue Z, Yuan Z, Zeng L, Wang Y, Lai L, Li J, Sun P, Xue X, Qi J, Yang Z, Zheng Y, Fang Y, Li D, Siwko S, Li Y, Luo J, Liu M. FASEB J. 2017 Dec 21.
Wei Y, Zhang XH, Li DL*. The new favorite of gene editing technology-single base editors. Yi Chuan. 2017 Dec 20;39(12):1115-1121. （invited review）
Peng W, Li M, Li H, Tang K, Zhuang J, Zhang J, Xiao J, Jiang H, Li D, Yu Y, Sham PC, Nattel S, Xu Y. Dysfunction of Myosin Light-Chain 4 (MYL4) Leads to Heritable Atrial Cardiomyopathy With Electrical, Contractile, and Structural Components: Evidence From Genetically-Engineered Rats. J Am Heart Assoc. 2017 Oct 28;6(11).
Sun M, Ding J, Li D, Yang G, Cheng Z, Zhu Q. NUDT21 regulates 3'-UTR length and microRNA-mediated gene silencing in hepatocellular carcinoma. Cancer Lett. 2017 Dec 1;410:158-168.
Liu XM, Zhang YL, Ji SY, Zhao LW, Shang WN, Li D, Chen Z, Tong C, Fan HY. Mitochondrial Function Regulated by Mitoguardin-1/2 Is Crucial for Ovarian Endocrine Functions and Ovulation. Endocrinology. 2017 Nov 1;158(11):3988-3999
Liu Y, Fan C, Zhang Y, Yu X, Wu X, Zhang X, Zhao Q, Zhang H, Xie Q, Li M, Li X, Ding Q, Ying H, Li D, Zhang H. RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice. Cell Death Differ. 2017 Aug;24(8):1459-1469
Zhang X, Wang L, Liu M, Li D*. CRISPR/Cas9 system: a powerful technology for in vivo and ex vivo gene therapy. Sci China Life Sci. 2017 May;60(5):468-475 （invited review）
Zhang L, Li L, Gao G, Wei G, Zheng Y, Wang C, Gao N, Zhao Y, Deng J, Chen H, Sun J, Li D*, Zhang X*, Liu M*. Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress. Int J Cancer. 2017 Jun 15;140(12):2734-2747 （Cover story）
Chen Y, Ma J, Lu W, Tian M, Thauvin M, Yuan C, Volovitch M, Wang Q, Holst J, Liu M, Vriz S, Ye S*, Wang L*, Li D*. Heritable expansion of the genetic code in mouse and zebrafish. Cell Res. 2017 Feb;27(2):294-297.
Lu J, Shao Y, Qin X, Liu D, Chen A, Li D*, Liu M*, Wang X*.CRISPR knockout rat cytochrome P450 3A1/2 model for advancing drug metabolism and pharmacokinetics research.Sci Rep. 2017 Feb 20;7:42922..
Chen R, Zhang Q, Duan X, York P, Chen GD, Yin P, Zhu H, Xu M, Chen P, Wu Q, Li D, Samarut J, Xu G, Zhang P, Cao X, Li J, Wong J. The 5-hydroxymethylcytosine (5hmC) reader Uhrf2 is required for normal levels of 5hmC in mouse adult brain and spatial learning and memory.J Biol Chem. 2017 Jan 23. pii: jbc.M116.754580
Wei Y, Chen Y, Qiu Y, Zhao H, Liu G, Zhang Y, Meng Q, Wu G, Chen Y, Cai X, Wang H, Ying H, Zhou B, Liu M, Li D, Ding Q. Prevention of Muscle Wasting by CRISPR/Cas9-mediated Disruption of Myostatin In Vivo.Mol Ther. 2016 Nov;24(11):1889-1891.
You P, Hu H, Chen Y, Zhao Y, Yang Y, Wang T, Xing R, Shao Y, Zhang W, Li D*, Chen H*, Liu M*. Effects of Melanocortin 3 and 4 Receptor Deficiency on Energy Homeostasis in Rats. Sci Rep. 2016 Oct 7;6:34938.
Chen Y, Liu X, Zhang Y, Wang H, Ying H, Liu M, Li D, Lui KO, Ding Q. A Self-restricted CRISPR System to Reduce Off-target Effects. Mol Ther. 2016 Sep;24(9):1508-10.
Zhang L, Shao Y, Li L, Tian F, Cen J, Chen X, Hu D, Zhou Y, Xie W, Zheng Y, Ji Y, Liu M, Li D*, Hui L*. Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I. Sci Rep. 2016 Aug 11;6:31460
Chen Y, Lu W, Gao N, Long Y, Shao Y, Liu MZ, Chen H, Ye S, Ma X, Liu M*, Li D*. Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene. Sci China Life Sci. 2016 60(2):152-157.
Luo J, Yang Z, Ma Y, Yue Z, Lin H, Qu G, Huang J, Dai W, Li C, Zheng C, Xu L, Chen H, Wang J, Li D, Siwko S, Penninger JM, Ning G, Xiao J, Liu M. LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption. Nat Med. 2016 May;22(5):539-46
Zhang Y, Zeng Z, Zhao J, Li D, Liu M, Wang X.Measurement of Rhodamine 123 in Three-Dimensional Organoids: A Novel Model for P-Glycoprotein Inhibitor Screening.Basic Clin Pharmacol Toxicol. 2016 Apr 6.
Guan Y, Ma L, Li Q, Sun Z, Ma Li, Wu L, Wang L, Zeng L, Shao Y, Chen Y, Ma N, Lu W, Hu K, Han H, Yu Y, Huang Y, Liu M*, Li D*. CRISPR/Cas9 mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse. EMBO MOL MED. 2016 May 2;8(5):477-88.
Wang X*, Tang Y, Lu J, Shao Y, Qin X, Li Y, Wang L, Li D*,Liu M*. Characterization of novel cytochrome P450 2E1 knockout rat model generated by CRISPR/Cas9. Biochem Pharmacol. 2016 Apr 1;105:80-90.
Liu XM, Zhang YP, Ji SY, Li BT, Tian X, Li D, Tong C, Fan HY. Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions. Oncotarget. 2016 Jan 12;7(2):1155-67.
Wang L, Shao Y, Guan Y, Li L, Wu L, Chen F, Liu M, Chen H, Ma Y, Ma X, Liu M*, Li D*. Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos.Sci Rep. 2015 Dec 1;5:17517
Bai M, Li Q, Shao Y, Huang Y, Li D*, Ma Y*. Generation of site-specific mutant mice using the CRISPR/Cas9 system.Yi Chuan. 2015 Oct;37(10):1029-35.
Guan Y, Zhang L, Li X, Zhang X, Liu S, Gao N, Li L, Gao G, Wei G, Chen Z, Zheng Y, Ma X, Siwko S, Chen JL, Liu M*, Li D*.Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models. J Immunol. 2015 May 29. pii: 1303356
Liu XM, Zhang YP, Ji SY, Li BT, Tian X,Li D, Tong C, Fan HY. Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions.Oncotarget. 2015 doi: 10.18632/oncotarget.6713
Deng L, Jiang C, Chen L, Jin J, Wei J, Zhao L, Chen M, Pan W, Xu Y, Chu H, Wang X, Ge X, Li D, Liao L, Liu M, Li L, Wang P. The Ubiquitination of RagA GTPase by RNF152 Negatively Regulates mTORC1 Activation. Mol Cell. 2015 Jun 4;58(5):804-18
Fan G, Sun L, Shan P, Zhang X, Huan J, Zhang X, Li D, Wang T, Wei T, Zhang X, Gu X, Yao L, Xuan Y, Hou Z, Cui Y, Cao L, Li X, Zhang S, and Wang C. Loss of KLF14 triggers centrosome amplification and tumorigenesis. Nat Commun 2015 Oct 6;6:8450
Fang P, Xu W, Li D, Zhao X, Dai J, Wang Z, Yan X, Qin M, Zhang Y, Xu C, Wang L, Qiao Z. A novel acrosomal protein, IQCF1, involved in sperm capacitation and the acrosome reaction. Andrology. 2015 Mar;3(2):332-44.
Guan Y, Shao Y, Li D*，Liu M*. Generation of Site-Specific Mutations in the Rat Genome Via CRISPR/Cas9. Methods Enzymol. 2014 ;546:297-317
Shao Y, Guan Y, Wang L, Qiu Z, Liu M, Chen Y, Wu L, Li Y, Ma X, Liu M*, Li D*. Genome editing in the rat using CRISPR-Cas and injection of RNAs into one-cell embryos. Nature Protocols. 2014 (10):2493-512
Cui H, Wang Y, Huang H, Yu W, Bai M, Zhang L, Bryan BA, Wang Y, Luo J, Li D*, Ma Y*, Liu M*.GPR126 Regulates Developmental and Pathological Angiogenesis through Modulation of VEGFR2 Signaling. J Biol Chem.2014 Sep 12. pii: jbc.M114.571000
Guan X, Duan Y, Zeng Q, Pan H, Qian Y, Li D*, Cao X*, Liu M*. Lgr4 Deficiency Induces Ataxia-like Phenotype in Mice and Impairs Long-term Depression at Cerebellar Parallel fiber-Purkinje Cell Synapses.J Biol Chem. 2014 Sep 19;289(38):26492-504.
Pan H, Cui H, Liu S, Qian Y, Wu H, Li L, Guan Y, Guan X, Zhang L, Fan HY, Ma Y, Li R, Liu M*,Li D*. Lgr4 gene regulates Corpus Luteum Maturation through Modulation of the WNT mediated EGFR-ERK Signaling Pathway. Endocrinology. 2014 May 30:en20132183.
Yi T, Weng J, Siwko S, Luo J, Li D, Liu M.LGR4/GPR48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects. J Biol Chem. 2014 Mar 28;289(13):8767-80
Li D*, Qiu Z, Shao Y, Chen Y, Guan Y, Liu M, Li Y, Gao N, Wang L, Lu X, Zhao Y*, Liu M*. Heritable gene targeting in the mouse and rat using a CRISPR-Cas system. Nature Biotechnol. 2013 ;31(8):681-3.
Qiu Z, Liu M, Chen Z, Shao Y, Pan H, Wei G, Yu C, Zhang L, Li X, Wang P, Fan HY, Du B, Liu B, Liu M, Li D*. High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Nucleic Acids Res. 2013 Jun;41(11):e120.
Liu S, Qian Y, Li L, Wei G, Guan Y, Pan H, Guan X, Zhang L, Lu X, Zhao Y, Liu M*, Li D*.Lgr4 deficiency increases susceptibility and severity of dextran sodium sulphate induced inflammatory bowel disease in mice. J Biol Chem. 2013 288: 8794-8803. [paper of the week]
Qian Y, Liu S, Guan Y, Pan H, Guan X, Qiu Z, Li L, Gao N, Zhao Y, Li X, Lu Y, Liu M*, Li D.* Lgr4 mediated Wnt/β-catenin signaling in peritubular myoid cells is essential for spermatogenesis. Development. 2013;140(8):1751-61.
Luo W, Rodriguez M, Valdez JM, Zhu X, Tan K, Li D, Siwko S, Xin L, Liu M. Lgr4 is a Key Regulator of Prostate Development and Prostate Stem Cell Differentiation. Stem Cells. 2013;31(11):2492-505.
Wang Y, Dong J, Li D, Lai L, Siwko S, Li Y, Liu M. Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2. Stem Cells. 2013;31(9):1921-31.
Du B, Luo W, Li R, Tan B, Han H, Lu X, Li D, Qian M, Zhang D, Zhao Y, Liu M. Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression. J Biol Chem. 2013; 288(21):15131-41.
年以前
Yu W, Qiu Z, Gao N, Wang L, Cui H, Qian Y, Jiang L, Luo J, Yi Z, Lu H, Li D*, and Liu M* PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53-MDM2 loop, Nucleic Acids Res 2010 39(6):2234-48.
Yang Z, Li C, Wang X, Zhai C, Yi Z, Wang L, Liu B, Du B, Wu H, Guo X, Liu M, Li D*, Luo J*. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010 Oct;225(1):266-75.
Li, D., Yu, W. and Liu, M. (2009) Regulation of KiSS1 gene expression. Peptides, 30, 130-138.
Li, D*., Niu, Z., Yu, W., Qian, Y., Wang, Q., Li, Q., Yi, Z., Luo, J., Wu, X., Wang, Y. Schwartz RJ, Liu M. (2009) SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin. Nucleic Acids Res, 37, 7059-7071.
Li, D., Mitchell, D., Luo, J., Yi, Z., Cho, S.G., Guo, J., Li, X., Ning, G., Wu, X. and Liu, M. (2007) Estrogen regulates KiSS1 gene expression through estrogen receptor alpha and SP protein complexes. Endocrinology, 148, 4821-4828.
Cho SG, Li D, Tan K, Siwko SK, Liu M. KiSS1 and its G-protein-coupled receptor GPR54 in cancer development and metastasis. Cancer Metastasis Rev. 2012；31(3-4):585-91.
Dai F, Chen Y, Song Y, Huang L, Zhai D, Dong Y, Lai L, Zhang T, Li D, Pang X, Liu M, Yi Z. A natural small molecule harmine inhibits angiogenesis and suppresses tumour growth through activation of p53 in endothelial cells. PLoS One. 2012;7(12):e52162
Cho SG, Wang Y, Rodriguez M, Tan K, Zhang W, Luo J, Li D, Liu M Haploinsufficiency in the prometastasis Kiss1 receptor Gpr54 delays breast tumor initiation, progression, and lung metastasis. Cancer Res. 2011 15;71(20):6535-46.
Dong Y, Lu B, Zhang X, Zhang J, Lai L, Li D, Wu Y, Song Y, Luo J, Pang X, Yi Z, Liu M. Cucurbitacin E, a Tetracyclic Triterpenes Compound from Chinese Medicine, Inhibits Tumor Angiogenesis through VEGFR2 Mediated Jak2/STAT3 Signaling Pathway.Carcinogenesis.2010 Aug 23
Yi, T., Tan, K., Cho, S.G., Wang, Y., Luo, J., Zhang, W.,Li, D. and Liu, M. Regulation of embryonic kidney branching morphogenesis and glomerular development by KISS1 receptor (GPR54) through NFAT2 and SP1 mediated bmp7 expression. J Biol Chem. 285(23):17811-20
Li, X.Y., Lu, Y., Sun, H.Y., Wang, J.Q., Yang, J., Zhang, H.J., Fan, N.G., Xu, J., Jiang, J.J., Liu, R.Y., Li,D. et al. (2010) G protein-coupled receptor 48 upregulates estrogen receptor alpha expression via cAMP/PKA signaling in the male reproductive tract. Development, 137, 151-157.
Li, C., Yang, Z., Zhai, C., Qiu, W., Li, D., Yi, Z., Wang, L., Tang, J., Qian, M., Luo, J. et al. Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor alpha by inhibiting NF-kappaB signaling pathway. Mol Cancer, 9, 73
Yi, Z.F., Cho, S.G., Zhao, H., Wu, Y.Y., Luo, J., Li, D., Yi, T., Xu, X., Wu, Z. and Liu, M. (2009) A novel peptide from human apolipoprotein(a) inhibits angiogenesis and tumor growth by targeting c-Src phosphorylation in VEGF-induced human umbilical endothelial cells. Int J Cancer, 124, 843-852.
Wang, L., Kuang, L., Pan, X., Liu, J., Wang, Q., Du, B., Li, D., Luo, J., Liu, M., Hou, A. et al. (2010) Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1. Int J Cancer. 127(5):1220-9
Luo, J., Zhou, W., Zhou, X., Li, D., Weng, J., Yi, Z., Cho, S.G., Li, C., Yi, T., Wu, X. et al. (2009) Regulation of bone formation and remodeling by G-protein-coupled receptor 48. Development, 136, 2747-2756.
Cho, S.G., Yi, Z., Pang, X., Yi, T., Wang, Y., Luo, J., Wu, Z., Li, D. and Liu, M. (2009) Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activation. Cancer Res, 69, 7062-7070.
Cho, S.G., Li, D., Stafford, L.J., Luo, J., Rodriguez-Villanueva, M., Wang, Y. and Liu, M. (2009) KiSS1 suppresses TNFalpha-induced breast cancer cell invasion via an inhibition of RhoA-mediated NF-kappaB activation. J Cell Biochem, 107, 1139-1149.
Yu, W., Li, Y., Zhou, X., Deng, Y., Wang, Z., Yuan, W., Li, D., Zhu, C., Zhao, X., Mo, X. et al. (2008) A novel human BTB-kelch protein KLHL31, strongly expressed in muscle and heart, inhibits transcriptional activities of TRE and SRE.Mol Cells, 26, 443-453.
Weng, J., Luo, J., Cheng, X., Jin, C., Zhou, X., Qu, J., Tu, L., Ai, D., Li, D., Wang, J. et al.(2008) Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A, 105, 6081-6086.
Song, H., Luo, J., Luo, W., Weng, J., Wang, Z., Li, B., Li, D. and Liu, M. (2008) Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway. J Biol Chem, 283, 36687-36697.
Ma, W., Stafford, L.J., Li, D., Luo, J., Li, X., Ning, G. and Liu, M. (2007) GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis. J Cell Biochem, 100, 1376-1386.
Mitchell DC, Stafford LJ, Li D, Bar-Eli M, Liu M. (2007) Transcriptional regulation of KiSS-1 gene expression in metastatic melanoma by specificity protein-1 and its coactivator DRIP-130. Oncogene. 26(12):1739-47
Zhu Y, Wang Y, Xia C, Li D, Li Y, Zeng W, Yuan W, Liu H, Zhu C, Wu X, Liu M. WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway.J Cell Biochem. 2004 93(3):579-87
Huang C, Wang Y, Li D, Li Y, Luo J, Yuan W, Ou Y, Zhu C, Zhang Y, Wang Z, Liu M, Wu X. Inhibition of transcriptional activities of AP-1 and c-Jun by a new zinc finger protein ZNF394. Biochem Biophys Res Commun. 2004 320(4):1298-305.
Yi Z, Li Y, Ma W, Li D, Zhu C, Luo J, Wang Y, Huang X, Yuan W, Liu M, Wu X. A novel KRAB zinc-finger protein, ZNF480, expresses in human heart and activates transcriptional activities of AP-1 and SRE.Biochem Biophys Res Commun. 320(2):409-15.
Liu H, Zhu C, Luo J, Wang Y, Li D, Li Y, Zhou J, Yuan W, Ou Y, Liu M, Wu X. ZNF411, a novel KRAB-containing zinc-finger protein, suppresses MAP kinase signaling pathway.Biochem Biophys Res Commun. 2004;320(1):45-53.
Zeng W, Yuan W, Wang Y, Jiao W, Zhu Y, Huang C, Li D, Li Y, Zhu C, Wu X, Liu M. Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development.Biochem Biophys Res Commun. 2002 299(4):542-8.
京公网安备 11010802027423号