个人简介
1991年获华东师范大学生物学理学博士学位毕业后留校任教。1994年在华东师范大学晋升为副教授,2002年晋升为教授、博士生导师。2006年任生命医学系主任,2007年兼任生命医学研究所副所长,2012-2017年任生命科学学院副院长等。同时任美国免疫学会会员、《现代免疫学》杂志常务编委、《高校生物学教学研究》杂志常务编委等。曾先后担任教育部高等学校教学指导委员会委员、2届上海市科委上海科技发展重点领域预见专家、司法部司法鉴定科学技术研究所上海市法医学重点实验室学术委员会委员,以及中国免疫学会理事、上海市免疫学学会理事兼副秘书长。
近年来一直从事:(1)G蛋白偶联受体(GPCR)在固有免疫应答尤其感染、炎症以及肿瘤免疫微环境中的调控功能和机制研究,成功建立了细菌及病毒感染、炎症以及肿瘤发生及转移等体内外疾病模型,并对嘌呤受体家族成员在细菌、病毒感染、炎症及肿瘤免疫中的重要作用进行了系统研究,进一步丰富了胞外核苷酸作为危险信号分子在固有免疫调控中的重要作用。(2)建立了具有自主产权的纳米抗体库,并获得多个肿瘤特异性抗体和免疫检查点抗体,实验表明基于这些抗体具有较好的靶向治疗效果,获得了原创性成果。近年来,作为课题负责人承担了国家自然科学基金项目、国家高等学校骨干教师项目、上海市科委和上海市教委重点项目等24项,参与了十余项国家重大专项、“863”项目等。在国内外学术刊物上发表论文140余篇,主编国家“十一五”规划教材《免疫学原理与技术》和《免疫生物学》(主译),参与2部专著的编撰,申请中国发明专利15项,其中已获得授权专利6项。
教育经历
1988.9~1991.7 上海华东师范大学生物学系理学博士
1983.9~1986.7 上海华东师范大学生物学系理学硕士
1979.9~1983.7 上海华东师范大学生物学系理学学士
工作经历
200208~ 今 华东师范大学生命科学学院教授
199408~200208 华东师范大学生物学系副教授
199107~199408 华东师范大学生物学系讲师
198607~198809 苏州铁道师范学院生物学系讲师
研究领域
G-蛋白偶联受体在固有免疫中的调控及分子机理
炎症反应在感染、肿瘤中的作用及机制
新型抗体药物的筛选及开发
近期论文
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Xiong Qingqing ?,Huang Hongjun?,Wang Ning,Chen Ruoyu,Chen Naiyang,Han Honghui,Wang Qin,Siwko Stefan,Liu Mingyao,Qian Min and Du Bing*.Metabolite-Sensing G Protein Coupled Receptor TGR5 Protects HostFrom Viral Infection Through Amplifying Type I Interferon Responses.Frontiers in Immunology,2018,Oct 2,9:2289
Hongjun Huang#,Qingqing Xiong#, NingWang#,Ruoyu Chen,Hua Ren,Stefan Siwko,Honghui Han,Mingyao Liu,Min Qian* and Bing Du*.Kisspeptin/GPR54 signaling restricts antiviral innate immuneresponse through regulating calcineurin phosphatase activity.Science Advances,2018,Vol. 4, no. 8, eaas9784
Tan Binghe,Xiujuan Shi,Jie Zhang,Juliang Qin,Na Zhang,Hua Ren,Qian Min,Stefan Siwko,Kendra Carmon,Qingyun Liu,Honghui Han,Bing Du* and Mingyao Liu*.Inhibitionof Rspo-Lgr4 facilitates checkpoint blockade therapy by switching macrophagepolarization.CancerResearch,2018,Jul 2
Yaru Shi , Zhenlong Li , RanChen , Jiang Zhang , Xuefei Hu , Cong He , Qiong Su , Hongdou Ma , Hua Ren ,Min Qian , Shufang Cui,Wenzheng Jiang*.Immethridine, histamine H3-receptor (H3R) agonist, alleviatedexperimental autoimmune encephalomyelitis via inhibiting the function ofdendritic cells.Oncotarget,2017,8:75038-75049.
Hongjun Huang,Na Zhang,Qingqing Xiong,Ruoyu Chen,Chengfei Zhang,Ning Wang,Li Wang,Hua Ren,Mingyao Liu,Min Qian,Bing Du*.Elimination of GPR146-mediated antiviral function throughIRF3/HES1-signaling pathway.Immunology,2017,Sep,152(1):102-114
Xiaoyu Zhang,Juliang Qin,Junyan Zou,Zhangsheng Lv,Binghe Tan,Jueping Shi,Yihan Zhao,Hua Ren,Mingyao Liu,Min Qian,Bing Du*.Extracellular ADP facilitates monocyte recruitment inbacterial infection via ERK signaling.Cellular &Molecular Immunology,2016,Nov 21,
Qin Juliang,Zhang Xiaoyu,Wang Ziqiang,Li Jinju,Zhang Zhen,Ren Hua,Qian Min,Du Bing*.Presenilin 2 deficiency facilitates Aβ-induced neuroinflammationand injury by upregulating P2X7 expression.SCIENCE CHINA LifeSciences,2016,Dec 21
Xiaobin Ma,Xinhua Pan,Yinglei Wei,Binhe Tan,Linli Yang,Hua Ren,Min Qian,Bing Du*.Chemotherapy-induced uridine diphosphate release promotesbreast cancer metastasis through P2Y6 activation.Oncotarget,2016,7(20):29036-29050
Xiaoyu Zhang,Juliang Qin,Yihan Zhao,Jueping Shi,Rong Lan,Yunqiu Gan,Hua Ren,Bing Zhu,Min Qian,Bing Du*.Long-term ketogenic diet contributes to glycemic control butpromotes lipid accumulation and hepatic steatosis in type 2 diabetic mice.Nutrition Research,2016,36(4):349-58
Jueping Shi,Xiaoyu Zhang,Shaoying Wang,Jinjin Wang,Bing Du,Zhugang Wang,Mingyao Liu,Wenzheng Jiang,Min Qian,Hua Ren*.Gpr97 is dispensable for metabolic syndrome but is involved inmacrophage inflammation in high-fat diet-induced obesity in mice.Scientific Report,2016,Apr 19,6:24649.
Jueping Shi,Shaoying Wang,Lili Chen,Xiaoyu Zhang,Yihan Zhao,Bing Du,Wenzheng Jiang,Min Qian,Hua Ren*.P2Y6 contributes to ovalbumin-induced allergic asthma by enhancingmast cell function in mice.Oncotarget,2016,Aug 31.
Juliang Qin,Guangxu Zhang,Xiaoyu Zhang,Binghe Tan,Zhangsheng Lv,Mingyao Liu,Hua Ren,Min Qian,Bing Du*.TLR-activated Gap Junction Channels Protects Mice againstBacterial Infection through Extracellular UDP Release.Journal of Immunology,2016,Feb15,196(4):1790-1798
Jinju Li,Guangxu Zhang,Dalong Cheng,Hua Ren,Min Qian,Bing Du*.Molecularcharacterization of RIG-I, STAT-1 and IFN-beta in the horseshoe bat. Gene,2015,Apr 25,561(1):115-123
Wei Gao,Zhewei Tang,Yi-Fan Zhang,Mingqian Feng,Min Qian,Dimiter S. Dimitrov & Mitchell Ho*.Immunotoxin targeting glypican-3 regresses liver cancer via dualinhibition of Wnt signalling and protein synthesis.Nature Communications,2015,6(3):1-12
Shi Jueping,Xiaoning Li,Xiaoyu Zhang,Bing Du,Wenzheng Jiang,Mingyao Liu,Jinjin Wang,Zhugang Wang,Hua Ren,Min Qian*.Gpr97 Is Dispensablefor Inflammation in OVA-Induced Asthmatic Mice.PLoS One,2015,Jul 1,10(7):e0131461
Bing Du,Weijia Luo,Ruimei Li,Binghe Tan,Honghui Han,X Lu,Dali Li,Min Qian,Dekai Zhang,Y Zhao,Mingyao Liu*.Lgr4/Gpr48 negatively regulates TLR2/4 associated patternrecognition and innate immunity by targeting CD14 expression.The Journal of Biological Chemistry,2013,May 24;288(21):15131-41
Zhao Fang,Meixia Zhang,Zhenghui Yi,Chengping Wen,Min Qian and Tieliu Shi*.Replacements of Rare Herbs and Simplifications of TraditionalChinese Medicine Formulae Based on Attribute Similarities and PathwayEnrichment Analysis.Evidence-BasedComplementary and Alternative Medicine,2013, 2013:136732. . Epub 2013 Feb 21
Jiani Du,Xiaoyu Wu,Fengying Long,Jiejun Wen,Wenli Hao,Ran Chen,Xiaobo Kong,Min Qian and Wenzheng Jiang.Improvement in Efficacy of DNA Vaccine Encoding HIV-1 Vif by LIGHTGene Adjuvant.Viral Immunol.,2013,Feb;26(1):68-74.
Tang Zhewei, Mingqian Feng,Wei Gao, Yen Phung, Weizao Chen, Amit Chaudhary, Brad St. Croix, Min Qian, Dimiter S. Dimitrov, Mitchell Ho*. A humansingle-domain antibody elicits potent anti-tumor activity by targeting anepitope in mesothelin close to the cancer cell surface. Mol Cancer Therapeutics,2013, Jan 31;12(4): 416-426
Tang Zhewei,Min Qian,MitchellHo*.The Role ofMesothelin in Tumor Progression and Targeted Therapy.Anti-cancer Agents inMedicinal Chemistry.2013,13:276-280
Zhao Qufei, Qian Yu, Li Ruimei, TanBinghe, Han Honghui, Liu Mingyao, Qian Min* and Du Bing*. Norcantharidin facilitatesLPS-mediated immune responses by up-regulation of AKT/NF-κBsignaling in macrophages. PLOSONE,2012,7(9):e44956
Wang Zhiqiang,JiangWei,ZhangZhi,QianMin,DuBing*. Nitidine Chloride inhibits LPS-induced inflammatory cytokines productionvia MAPK and NF-kappaB pathway in RAW 264.7 cells. Journal ofEthnopharmacology.2012,Oct31;144(1):145-50.
学术兼职
任美国免疫学会会员、《现代免疫学》杂志常务编委、《高校生物学教学研究》杂志常务编委等
曾先后担任教育部高等学校教学指导委员会委员、2届上海市科委上海科技发展重点领域预见专家、司法部司法鉴定科学技术研究所上海市法医学重点实验室学术委员会委员,以及中国免疫学会理事、上海市免疫学学会理事兼副秘书长
担任普陀区第十一届、十二届政协委员、普陀区第十五届人大代表,以及华东师范大学第五届、第六届民盟副主委