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研究领域

皮肤细胞的损伤与修复 皮肤抗衰、防皱、防晒、美白化妆品的研发 促毛发生长药物筛选及机制研究 影响黑色素生成的天然活性成分筛选与机制研究

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Xiaolin Ren, Weili Xia, Peng Xu, Hongyang Shen, Xing Dai, Mingyao Liu, Yuling Shi,Xiyun Ye*, Yongyan Dang. Lgr4 deletion delays the hair cycle and inhibits the activation of hair follicle stem cells. Journal of Investigative Dermatology, 2020, 140(9):1706-1712. Wu J,Li X,Li D,Ren X,Li Y,Herter EK,Qian M,Toma MA,Wintler AM,Sérézal IG,Rollman O,St?hle M,Wikstrom JD, Ye X*,Landén NX. MicroRNA-34 Family Enhances Wound Inflammation by Targeting LGR4. Journal of Investigative Dermatology, 2020, 140(2):465-476. Ting Fu,Bowen Chai,Yuling Shi,Yongyan Dang,Xiyun Ye*. Fargesin inhibits melanin synthesis in murine malignant and immortalized melanocytes by regulating PKACREB and P38MAPK signaling pathways. Journal of Dermatological Science, 2019,94:213–219. Qin Y, Qin X, Xu P, Zhi Y, Xia W, Dang Y, Gu J, Ye X*. Potential role of S100A8 in skin rejuvenation with the 1064-nm Q-switched Nd:YAG laser. Lasers Med Sci 2018; 33(3):581-588. Peng Xu, Yongyan Dang, Luyang Wang, Xia Liu, Xiaolin Ren, Jun Gu, Mingyao Liu, Xing Dai, Xiyun Ye*. Lgr4 is crucial for skin carcinogenesis by regulating MEK/ ERK and Wnt/β-catenin signaling pathways. Cancer Letters, 2016, 383: 161-170. Xiaolin Ren, Yuling Shi, Di Zhao, Mengyu Xu, Xiaolong Li, Yongyan Dang, Xiyun Ye*.Naringin protects ultraviolet B-induced skin damage by regulating p38 MAPK signal pathway. Journal of Dermatological Science,2016, 82(2):106–114. Xiaolin Ren, Minggai Ge, Xiaofeng Qin, Peng Xu, Pingya Zhu, Yongyan Dang, Jun Gu, Xiyun Ye*. S100a8/NF-κB signal pathway is involved in the 800-nm diode laser-induced skin collagen remodeling. Lasers in Medical Science,2016, 31:673–678. Pingya Zhu, Weihan Yin, Mengran Wang, Yongyan Dang,Xiyun Ye*. Andrographolide suppresses melanin synthesis through Akt/GSK3β/β-catenin signal pathway.Journal of Dermatological Science, 2015, 79:74-83. Yimiao Zhai, Yongyan Dang, Wenke Gao, Ye Zhang, Peng Xu, Jun Gu andXiyun Ye*.P38 and JNK signal pathways are involved in the regulation of phlorizin against UVB-induced skin damage. Experimental Dermatology,2015,24(4):275-279. Di Zhao, Yuling Shi, Yongyan Dang, Yimiao Zhai,Xiyun Ye*. Daidzein stimulates collagen synthesis by activating the TGF-β/smad signal pathway. Australasian Journal of Dermatology, 2015,56,e7–e14. Yongyan Dang, Bei Liu, Peng Xu, Pingya Zhu, Yimiao Zhai, Mingyao Liu,Xiyun Ye*. Gpr48 Deficiency Induces Polycystic Kidney Lesions and Renal Fibrosis in Mice by Activating Wnt Signal Pathway. PLoS ONE, 2014, 9(3): e89835-89844. Guoliang Li, Yundong He, Wenbo Zhou, Peng Wang, Yong Zhang, Weiguang Tong, Haigang Wu, Mingyao Liu,Xiyun Ye*, and Yihua Chen. Identification, synthesis and photo-protection evaluation of aryl thiazole derivatives as a novel series of sunscreens. HETEROCYCLES, 2014, 89(2): 453-464. Xiaoyun C heng, Wenke G ao, Yongyan Dang, Xia Liu, Yujuan Li, Xu Peng,Xiyun Ye*. Both ERK/MAPK and TGF-Beta/Smad Signaling Pathways Play a Role i n the Kidney Fibrosis of Diabetic Mice Accelerated by Blood Glucose Fluctuation. Journal of Diabetes Research, 2013:1-8. X. Ye*, X. Cheng, L. Liu, D. Zhao and Y. Dang. Blood glucose?uctuation affects skin collagen metabolism in the diabetic mouse by inhibiting the mitogen-activated protein kinase and Smad pathways. Clinical and Experimental Dermatology, 2013, 38(5):530–537. YD. He, YT. Liu, QX. Lin, J. Zhu, Y. Zhang, LY. Wang, X L. Ren,XY.Ye﹡. Polydatin suppresses ultraviolet B-induced cycooxygenase-2 expression in vitro and in vivo via reduced production of reactive oxygen species. British Journal of Dermatology, 2012, 167: 941-944. Xiyun Ye*,LuyangWang, Yongyan Dang, Bei Liu,DiZhao. Investigation of the 1064nm Q-Switched Nd:YAG Laser on Collagen Expression in an Animal Model.Photomedicine and laser surgery, 2012, 30(10):604-609. Zhao C,Wang Y,Su Y,Zhang H,Ding L,Yan X,Zhao D,Shao N,Ye X*,Cheng Y. Inclusion complexes of isoflavones with two commercially available dendrimers: solubility, stability, structures, release behaviors, and biocompatibility. International Journal of Pharmaceutics,2011,15; 421(2):301-309. Yongyan Dang, Bei Liu, Lianxi Liu ,Xiyun Ye*, Xinling Bi, Yong Zhang, Jun Gu. The 800-nm diode laser irradiation induces skin collagen synthesis by stimulating TGF-β/Smad signaling pathway,Lasers in Medical Science,2011,26(6):837-843. Yujing Weng,Yongyan Dang,Xiyun Ye*, Ning Liu, Zaichao Zhang, Qiushi Ren. Investigation of several non-ablative lasers irradiation on primary cultured skin fibroblasts,Clinical and Experimental Dermatology, 2011,36(6):655-660. Yongyan Dang,Xiyun Ye *,Yujing Weng,Zhi Tong,Qiushi Ren. Effects of the 532 nm and 1064 nm Q-switched Nd:YAG lasers on collagen turnover of cultured human skinfibroblasts : A comparative study. LasersMedical Science, 2010, 25:719-726. XiyunYe *, Zhi Tong, Yongyan Dang, Qian Tu, Yujing Weng, Jiang Liu, Zaichao Zhang. Effects of blood glucose fluctuation on skin biophysical properties, structure and antioxidant status in an animal model. Clinical and Experimental Dermatology, 2010, 35(1):78-82. 叶希韵 *. 紫外线致皮肤光老化研究进展. 生物学教学,2015, 40(11):2-5. 叶希韵 *,朱萍亚. 黑色素的合成与美白产品的研究进展. 华东师范大学学报(自然科学版),2016, 2016(2):1-8. 叶希韵 *,涂皘,童智,翁宇静,王耀发.葡萄糖浓度波动损伤牛血管内皮细胞的机制.中华心血管杂志, 2010, 38(3): 264-267. 党永岩,叶希韵 *,申杰.葡萄糖浓度波动对人肝L02细胞损伤的实验研究.华东师范大学学报(自然科学版), 2010, 150(5): 142-148. 张再超,叶希韵 *,徐敏华,王耀发.葛根黄酮降血糖防治糖尿病并发症的实验研究.华东师范大学学报(自然科学版), 2010, 150(2): 77-81.

学术兼职

上海细胞生物学会理事,上海市普陀区营养学会副理事长

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