个人简介
教育经历
2006,09 - 2009,11 华东师范大学 和 Wake Forest University School of Medicine, 联合培养博士
2003,09 - 2006,07 华东师范大学 生命科学学院 硕士 (导师: 孙心德 教授)
工作经历
2013.03 - 至今: 华东师范大学 生命科学学院
2009,12 - 2012.10 Wake Forest University School of Medicine, 博士后
研究领域
我的研究兴趣在于揭示大脑如何对感觉信号进行编码，多种感觉信号（视、听、体感等）如何相互影响和整合，及其如何转化成高级感知和运动指令；我的另一个研究目标还将投向与之相关的疾病研究，如外力所致的脑创伤，脑中风，抑郁症和婴幼儿时期生长环境异常所致的感觉-运动功能下降等疾病。目前开展的研究将主要运用多通道神经电生理记录、结合光遗传学和行为训练等方法来研究大脑多个部位如何进行感知觉信息分辨和决策，同时构建计算模型。具体为：
1. 大脑听觉及听-视多感觉整合的神经机制研究
2. 大脑的决策机制研究
3. 探索大脑对视、听、视-听线索的空间定位机制，构建计算模型为类脑人工智能提供神经原理
4. 大脑感知觉的康复机制研究
近期论文
查看导师新发文章
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Chang S, Xu J, Zheng M, Keniston L, Zhou X, Zhang J, Yu L#; Combining visual information into the auditory cortex promotes sound discrimination through choice-related multisensory integration.The Journal of Neuroscience.2022 (in press)
Han X, Xu J, Chang S, Keniston L, Yu L#. Multisensory-Guided Associative Learning Enhances Multisensory Representation in Primary Auditory Cortex. Cereb Cortex. 2022 Aug 10:bhab264.
Yu L, Hu J, Shi C, Zhou L, Tian M, Zhang J, Xu J.The causal role of auditory cortex in auditory working memory.Elife.2021;10:e64457.
Zheng M, Xu J, Keniston L, Wu J, Chang S, Yu L#. Choice-dependent cross-modal interaction in the medial prefrontal cortex of rats. Mol Brain. 2021;14(1):13
Yu L, Cuppini C., Xu J., Rowland BA, Stein BE. Cross-modal competition: The default computation for multisensory processing. Journal of Neuroscience. 2019
Xu J., Bi T., Wu J., Meng F., Wang K., Hu J., Han X.,Zhang J., Zhou X., Keniston L., Yu L.# Spatial receptive field shift by preceding cross-modal stimulation in cat superior colliculus. The Journal of Physiology. 2018
Xu,J., Bi,T., Keniston,L.,Zhang,J., Zhou,X., Yu,L.# Deactivation of Association CorticesDisrupted the Congruence of Visual and Auditory Receptive Fields in SuperiorColliculus Neurons. Cerebral Cortex; 2017
Yu, L., Xu, J., Rowland, B.A., and Stein, B.E. Multisensory Plasticity in Superior Colliculus Neurons is Mediated by Association Cortex. Cerebral cortex. 2016
Xu, J.*, Yu, L.*, Stanford, T.R., Rowland, B.A., and Stein, B.E. What does a neuron learn from multisensory experience? Journal of neurophysiology, 2015.
Xu j.,Sun X., Zhou X., Zhang J., and Yu L.# (2014) The cortical distribution of multisensory neurons was modulated by multisensory experience. Neuroscience 272,1-9.
Yu, L., Xu, J. Rowland, B.A., & Stein, B.E. （2013）Development of cortical influences on superior colliculus multisensory neurons: Effects of dark-rearing. Eur. J. Neurosci. 1011:1–8.
Yu, L., Rowland, B.A., Xu, J. & Stein, B.E. （2013）Multisensory plasticity in adulthood: cross-modal experience enhances neuronal excitability and exposes silent inputs. J Neurophysiol, 109, 464-474.
Xu J,Yu L, Rowland BA, Stanford TR and Stein BE (2012) Incorporating cross-modal statistics in the development and maintenance of multisensory integration. J. Neurosci.32: 2287-2298.
Yu L, Rowland BA, Stein BE (2010) Initiating the development of multisensory integration by manipulating sensory experience. J. Neurosci. 30:4904-4913.
Xu J, Yu L, Zhang J, Cai R, Sun X (2010) Early continuous white noise exposure alters l-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunit glutamate receptor 2 and gamma-aminobutyric acid type a receptor subunit beta3 protein expression in rat auditory cortex. J. Neurosci. Res. 88:614-619.
Yu L, Stein BE, Rowland BA (2009) Adult plasticity in multisensory neurons: short-term experience-dependent changes in the superior colliculus. J. Neurosci. 29:15910-15922.
Yu L*, Xu J*, Cai R, Zhang J, Sun X (2009) Early auditory enrichment with music enhances auditory discrimination learning and alters NR2B protein expression in rat auditory cortex. Behav. Brain Res. 196:49-54. (Co-first author).
Xu J, Yu L, Cai R, Zhang J, Sun X (2009) Early continuous white noise exposure alters auditory spatial sensitivity and expression of GAD65 and GABAA receptor subunits in rat auditory cortex. Cereb. Cortex 20:804-812.
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