杨嘉龙 - 华东师范大学 - 生命科学学院

个人简介

杨嘉龙，国家“优秀青年科学基金”获得者。中国科学院海洋研究所博士，美国杜克大学博士后，现任华东师范大学“紫江优秀青年学者”，教授，博士生导师，入选“上海市浦江人才计划”。多年来一直从事比较免疫学的研究工作，研究对象涉及海洋无脊椎动物、硬骨鱼、和哺乳动物，形成了进化上相对系统的研究体系。对深入开展水生动物免疫学机制研究，探索免疫系统的进化规律具有重要的指导意义。以第一作者或通讯作者在Advanced Science、Blood、eLIFE、PLoS Pathogens、FASEB J、The Journal of Immunology、Journal of Biological Chemistry等期刊上发表SCI论文40余篇。目前主要以鱼类为对象，开展T、B细胞的免疫调控机制研究。教育经历 2008.9-2011.7：中国科学院海洋研究所，海洋生物学，博士 2005.9-2008.7：中国海洋大学，水产养殖学，硕士 2001.9-2005.7：中国海洋大学，水产养殖系，学士工作经历 2017.4-至今：华东师范大学生命科学学院，紫江优秀青年学者，教授 2012.9-2016.1：美国杜克大学医学中心(Duke University Medical Center)，博士后 2011.7-2012.7：中国科学院烟台海岸带研究所，助理研究员社会兼职华东师范大学“紫江优秀青年学者” 上海市“浦江人才计划” 青岛海洋科学与技术试点国家实验室，海洋生物学与生物技术功能实验室PI 河口海岸国家重点实验室PI 担任中国水产学会鱼病专业委员会学术委员、中国水产学会水生动物免疫学委员会学术委员担任Fish & Shellfish Immunology Report编委担任Advanced Science、Reviews in Aquaculture、The Journal of Immunology、Frontiers in Immunology、Frontiers in Cell and Developmental Biology、Developmental and Comparative Immunology、Fish & Shellfish Immunology等十余份SCI期刊的审稿人

研究领域

鱼类免疫学--鱼类T、B淋巴细胞激活、增殖、分化的调控机制，及在免疫防御中的作用比较免疫学--从系统发生的角度，研究处于不同进化地位的动物（水生动物为主）的免疫系统，总结免疫系统的进化规律

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

第一/通讯作者（更新至2023年4月） Glutamine Metabolism Underlies the Functional Similarity of T Cells between Nile Tilapia and Tetrapod. Li K, Wei X, Jiao X, Deng W, Li J, Liang W, Zhang Y, Yang J. Advanced Science. 2023 Mar 8:e2201164. TGF-β1 suppresses the T-cell response in teleost fish by initiating Smad3- and Foxp3-mediated transcriptional networks. Zhang Q, Geng M, Li K, Gao H, Jiao X, Ai K, Wei X, Yang J. J Biol Chem. 2023 Feb;299(2):102843. IL-10 Negatively Controls the Primary T Cell Response of Tilapia by Triggering the JAK1/STAT3/SOCS3 Axis That Suppresses NF-κB and MAPK/ERK Signaling. Li K, Li J, Wei X, Wang J, Geng M, Ai K, Liang W, Zhang J, Li K, Gao H, Yang J. J Immunol. 2023 Feb 1;210(3):229-244. IL-2-mTORC1 signaling coordinates the STAT1/T-bet axis to ensure Th1 cell differentiation and anti-bacterial immune response in fish. Ai K, Li K, Jiao X, Zhang Y, Li J, Zhang Q, Wei X, Yang J. PLoS Pathogens. 2022 Oct 25;18(10):e1010913. Activated T cells are the cellular source of IL-22 that enhances proliferation and survival of lymphocytes in Nile tilapia. Jiao X, Li K, Geng M, Li K, Liang W, Zhang J, Zhang Q, Gao H, Wei X, Yang J. Fish Shellfish Immunol. 2022 Aug 5;128:216-227. High-fat diet blunts T-cell responsiveness in Nile tilapia. Li K, Zhu J, Li K, Liang W, Zhang J, Zhang Q, Jiao X, Wang X, Wei X, Yang J. Dev Comp Immunol. 2022 Oct;135:104495. ZAP70 activation is an early event of T cell immunity that involved in the anti-bacterial adaptive immune response of Nile tilapia. Li J, Liang W, Li K, Jiao X, Ai K, Zhang Y, Wei X, Yang J. Dev Comp Immunol. 2021 Nov;124:104177. An atypical KLRG1 in Nile tilapia involves in adaptive immunity as a potential marker for activated T lymphocytes. Zhang Y, Li K, Li C, Liang W, Li K, Li J, Wei X, Yang J. Fish Shellfish Immunol. 2021 Jun;113:51-60. Fish NF-κB couples TCR and IL-17 signals to regulate ancestral T-cell immune response against bacterial infection. Wei X, Li C, Zhang Y, Li K, Li J, Ai K, Li K, Zhang J, Yang J. FASEB J. 2021 Apr;35(4):e21457. kt1/mTORC1 signaling modulates adaptive immune response of Nile tilapia by promoting lymphocyte activation and proliferation. Ai K, Yan J, Li K, Li C, Zhang Y, Liang W, Li J, Wei X, Yang J. Dev Comp Immunol. 2021 Jun;119:104042. The involvement of TNF-α and TNF-β as proinflammatory cytokines in lymphocyte-mediated adaptive immunity of Nile tilapia by initiating apoptosis. Li K, Qiu H, Yan J, Shen X, Wei X, Duan M, Yang J. Dev Comp Immunol. 2021 Feb;115:103884. DGK α and ζ Activities Control TH1 and TH17 Cell Differentiation. Yang J, Wang HX, Xie J, Li L, Wang J, Wan ECK, Zhong XP. Front Immunol. 2020 Jan 15;10:3048. The evolutionarily conserved MAPK/Erk signaling promotes ancestral T-cell immunity in fish via c-Myc-mediated glycolysis. Wei X, Zhang Y, Li C, Ai K, Li K, Li H, Yang J. J Biol Chem. 2020 Mar 6;295(10):3000-3016. Raptor/mTORC1 Acts as a Modulatory Center to Regulate Anti-bacterial Immune Response in Rockfish. Li K, Wei X, Zhang L, Chi H, Yang J. Front Immunol. 2019 Dec 18;10:2953. Ca2+-Calcineurin Axis-Controlled NFAT Nuclear Translocation Is Crucial for Optimal T Cell Immunity in an Early Vertebrate. Wei X, Li H, Zhang Y, Li C, Li K, Ai K, Yang J. J Immunol. 2020 Feb 1;204(3):569-585. IκBα phosphorylation and associated NF-κB activation are essential events in lymphocyte activation, proliferation, and anti-bacterial adaptive immune response of Nile tilapia. Li C, Yu J, Ai K, Li H, Zhang Y, Zhao T, Wei X, Yang J. Dev Comp Immunol. 2020 Feb;103:103526. Ancestral T Cells in Fish Require mTORC1-Coupled Immune Signals and Metabolic Programming for Proper Activation and Function. Wei X, Ai K, Li H, Zhang Y, Li K, Yang J. J Immunol. 2019 Sep 1;203(5):1172-1188. The bacteriolytic mechanism of an invertebrate-type lysozyme from mollusk Octopus ocellatus. Li H, Wei X, Yang J, Zhang R, Zhang Q, Yang J. Fish Shellfish Immunol. 2019 Oct;93:232-239. Involvement of H-Ras in the adaptive immunity of Nile tilapia by regulating lymphocyte activation. Wei X, Zhao T, Zhang Y, Ai K, Li H, Yang J. Fish Shellfish Immunol. 2019 Jun;89:281-289. c-Raf participates in adaptive immune response of Nile tilapia via regulating lymphocyte activation. Wei X, Zhao T, Ai K, Zhang Y, Li H, Yang J. Fish Shellfish Immunol. 2019 Mar;86:507-515. Role of scavenger receptor from Octopus ocellatus as a co-receptor of Toll-like receptor in initiation of TLR-NF-κB signaling during anti-bacterial response. Wei X, Zhao T, Ai K, Li H, Jiang X, Li C, Wang Q, Yang J, Zhang R, Yang J. Dev Comp Immunol. 2018 Jul;84:14-27. Peptidoglycan recognition protein of Solen grandis (SgPGRP-S1) mediates immune recognition and bacteria clearance. Wei X, Yang D, Li H, Zhao T, Jiang H, Liu X, Yang J. Fish Shellfish Immunol. 2018 Feb;73:30-36. Sialic acid-binding lectins (SABLs) from Solen grandis function as PRRs ensuring immune recognition and bacterial clearance. Wei X, Yang D, Li H, Jiang H, Liu X, Zhang Q, Yang J. Fish Shellfish Immunol. 2018 Jan;72:477-483. Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses. Yang J, Lin X, Pan Y, Wang J, Chen P, Huang H, Xue HH, Gao J, Zhong XP. Elife. 2016 Sep 30;5:e17936. Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation. Yang J, Zhang P, Krishna S, Wang J, Lin X, Huang H, Xie D, Gorentla B, Huang R, Gao J, Li QJ, Zhong XP. Oncotarget. 2016 Jun 7;7(23):33744-64. Critical roles of sea cucumber C-type lectin in non-self recognition and bacterial clearance. Wei X, Liu X, Yang J, Wang S, Sun G, Yang J. Fish Shellfish Immunol. 2015 Aug;45(2):791-9. CfLec-3 from scallop: an entrance to non-self recognition mechanism of invertebrate C-type lectin. Yang J, Huang M, Zhang H, Wang L, Wang H, Wang L, Qiu L, Song L. Sci Rep. 2015 May 15;5:10068. Involvement of a Serpin serine protease inhibitor (OoSerpin) from mollusc Octopus ocellatus in antibacterial response. Wei X, Xu J, Yang J, Liu X, Zhang R, Wang W, Yang J. Fish Shellfish Immunol. 2015 Jan;42(1):79-87. A nonsense mutation in IKBKB causes combined immunodeficiency. Mousallem T, Yang J, Urban TJ, Wang H, Adeli M, Parrott RE, Roberts JL, Goldstein DB, Buckley RH, Zhong XP. Blood. 2014 Sep 25;124(13):2046-50. （共同第一） A four-domain Kunitz-type proteinase inhibitor from Solen grandis is implicated in immune response. Wei X, Yang J, Yang J, Liu X, Liu M, Yang D, Xu J, Hu X. Fish Shellfish Immunol. 2012 Dec;33(6):1276-84. Identification and transcriptional analysis of two types of lectins (SgCTL-1 and SgGal-1) from mollusk Solen grandis. Wei X, Yang J, Liu X, Yang D, Xu J, Fang J, Wang W, Yang J. Fish Shellfish Immunol. 2012 Aug;33(2):204-12. A sigma-class glutathione S-transferase from Solen grandis that responded to microorganism glycan and organic contaminants. Yang J, Wei X, Xu J, Yang D, Liu X, Yang J, Fang J, Hu X. Fish Shellfish Immunol. 2012 Jun;32(6):1198-204. Cloning and transcriptional analysis of two sialic acid-binding lectins (SABLs) from razor clam Solen grandis. Yang J, Wei X, Liu X, Xu J, Yang D, Yang J, Fang J, Hu X. Fish Shellfish Immunol. 2012 Apr;32(4):578-85. Molecular cloning and mRNA expression of two peptidoglycan recognition protein (PGRP) genes from mollusk Solen grandis. Wei X, Yang J, Yang D, Xu J, Liu X, Yang J, Fang J, Qiao H. Fish Shellfish Immunol. 2012 Jan;32(1):178-85. Two C-type lectins from shrimp Litopenaeus vannamei that might be involved in immune response against bacteria and virus. Wei X, Liu X, Yang J, Fang J, Qiao H, Zhang Y, Yang J. Fish Shellfish Immunol. 2012 Jan;32(1):132-40. A TRAF and TNF receptor-associated protein (TTRAP) in mollusk with endonuclease activity. Yang J, Qiu L, Wang L, Huang M, Wang L, Zhang H, Song L. Dev Comp Immunol. 2011 Aug;35(8):827-34. An interleukin-2 enhancer binding factor 2 homolog involved in immune response from Chinese mitten crab Eriocheir sinensis. Yang J, Wang L, Huang M, Wang L, Gai Y, Qiu L, Zhang H, Song L. Fish Shellfish Immunol. 2011 Jun;30(6):1303-9. C-type lectin in Chlamys farreri (CfLec-1) mediating immune recognition and opsonization. Yang J, Wang L, Zhang H, Qiu L, Wang H, Song L. PLoS One. 2011 Feb 15;6(2):e17089. Peptidoglycan recognition protein of Chlamys farreri (CfPGRP-S1) mediates immune defenses against bacterial infection. Yang J, Wang W, Wei X, Qiu L, Wang L, Zhang H, Song L. Dev Comp Immunol. 2010 Dec;34(12):1300-7. CfLGBP, a pattern recognition receptor in Chlamys farreri involved in the immune response against various bacteria. Yang J, Qiu L, Wang L, Wei X, Zhang H, Zhang Y, Liu L, Song L. Fish Shellfish Immunol. 2010 Nov;29(5):825-31. An ancient C-type lectin in Chlamys farreri (CfLec-2) that mediate pathogen recognition and cellular adhesion. Yang J, Qiu L, Wei X, Wang L, Wang L, Zhou Z, Zhang H, Liu L, Song L. Dev Comp Immunol. 2010 Dec;34(12):1274-82. Purification, virulence and characterization of an extracellular peptidase produced by Aeromonas salmonicida ssp. masoucida isolated from cultured sea cucumber Apostichopus japonicus. Yang JL, Zhan WB, Zhou L, Xing J. Dis Aquat Organ. 2008 Dec 22;82(3):223-9. 共同作者（更新至2022年8月） Interleukin-2 inducible T cell kinase (ITK) may participate in the anti-bacterial immune response of Nile tilapia via regulating T-cell activation. Liang W, Li K, Zhang Q, Li K, Ai K, Zhang J, Jiao X, Li J, Wei X, Yang J. Fish Shellfish Immunol. 2022 Aug;127:419-426. S6K1/S6 axis-regulated lymphocyte activation is important for adaptive immune response of Nile tilapia. Li K, Shen X, Qiu H, Zhao T, Ai K, Li C, Zhang Y, Li K, Duan M, Wei X, Yang J. Fish Shellfish Immunol. 2020 Nov;106:1120-1130. Galactoside-binding lectin in Solen grandis as a pattern recognition receptor mediating opsonization. Zhao T, Wei X, Yang J, Wang S, Zhang Y. Fish Shellfish Immunol. 2018 Nov;82:183-189. Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages. Deng W, Yang J, Lin X, Shin J, Gao J, Zhong XP. J Immunol. 2017 Jan 1;198(1):492-504. Polymorphism in a serine protease inhibitor gene and its association with the resistance of bay scallop (Argopecten irradians) to Listonella anguillarum challenge. Siva VS, Wang L, Qiu L, Zhou Z, Liu C, Yang J, Yang C, Song L. Fish Shellfish Immunol. 2016 Dec;59:1-8. mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium. Lin X, Yang J, Wang J, Huang H, Wang HX, Chen P, Wang S, Pan Y, Qiu YR, Taylor GA, Vallance BA, Gao J, Zhong XP. Sci Rep. 2016 Oct 12;6:34939. Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature. Petrovski S, Parrott RE, Roberts JL, Huang H, Yang J, Gorentla B, Mousallem T, Wang E, Armstrong M, McHale D, MacIver NJ, Goldstein DB, Zhong XP, Buckley RH. J Clin Immunol. 2016 Jul;36(5):462-71. Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection. Krishna S, Yang J, Wang H, Qiu Y, Zhong XP. Infect Immun. 2014 Jul;82(7):3045-57. iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. Wu J, Yang J, Yang K, Wang H, Gorentla B, Shin J, Qiu Y, Que LG, Foster WM, Xia Z, Chi H, Zhong XP. J Clin Invest. 2014 Apr;124(4):1685-98. Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. Wu J, Shen S, Yang J, Xia Z, Zhong XP. PLoS One. 2013 Sep 20;8(9):e75202. Identification of a LPS-induced TNF-α factor (LITAF) from mollusk Solen grandis and its expression pattern towards PAMPs stimulation. Yang D, Wei X, Yang J, Yang J, Xu J, Fang J, Wang S, Liu X. Fish Shellfish Immunol. 2013 Oct;35(4):1325-8. Two Rab GTPases, EsRab-1 and EsRab-3, involved in anti-bacterial response of Chinese mitten crab Eriocheir sinensis. Wang L, Li L, Wang L, Yang J, Wang J, Zhou Z, Zhang H, Song L. Fish Shellfish Immunol. 2013 Sep;35(3):1007-15. Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA. Pan H, O'Brien TF, Wright G, Yang J, Shin J, Wright KL, Zhong XP. J Immunol. 2013 Jul 15;191(2):699-707. Identification and characterization of a serine protease inhibitor Esserpin from the Chinese mitten crab Eriocheir sinensis. Wang L, Ma Z, Yang J, Gai Y, Zhou Z, Wang L, Yue F, Song L. Fish Shellfish Immunol. 2013 Jun;34(6):1576-86. The expression of immune-related genes during the ontogenesis of scallop Chlamys farreri and their response to bacterial challenge. Yue F, Shi X, Zhou Z, Wang L, Wang M, Yang J, Qiu L, Song L. Fish Shellfish Immunol. 2013 Mar;34(3):855-64. A four-CRD C-type lectin from Chlamys farreri mediating nonself-recognition with broader spectrum and opsonization. Huang M, Wang L, Yang J, Zhang H, Wang L, Song L. Dev Comp Immunol. 2013 Apr;39(4):363-9. Association between the polymorphism of CfPGRP-S1 gene and disease susceptibility/resistance of zhikong scallop (Chlamys farreri) to Listonella anguillarum challenge. Siva VS, Yang C, Yang J, Wang L, Wang L, Zhou Z, Qiu L, Song L. Fish Shellfish Immunol. 2012 Oct;33(4):736-42. A novel C1qDC protein acting as pattern recognition receptor in scallop Argopecten irradians. Wang L, Wang L, Kong P, Yang J, Zhang H, Wang M, Zhou Z, Qiu L, Song L. Fish Shellfish Immunol. 2012 Aug;33(2):427-35. Association of CfLGBP gene polymorphism with disease susceptibility/resistance of Zhikong scallop (Chlamys farreri) to Listonella anguillarum. Siva VS, Yang C, Yang J, Wang L, Wang L, Zhou Z, Qiu L, Song L. Fish Shellfish Immunol. 2012 Jun;32(6):1117-23. A multi-CRD C-type lectin with broad recognition spectrum and cellular adhesion from Argopectenirradians. Wang L, Wang L, Yang J, Zhang H, Huang M, Kong P, Zhou Z, Song L. Dev Comp Immunol. 2012 Mar;36(3):591-601. A dopa decarboxylase modulating the immune response of scallop Chlamys farreri. Zhou Z, Yang J, Wang L, Zhang H, Gao Y, Shi X, Wang M, Kong P, Qiu L, Song L. PLoS One. 2011 Apr 13;6(4):e18596. A novel C-type lectin from bay scallop Argopecten irradians (AiCTL-7) agglutinating fungi with mannose specificity. Kong P, Wang L, Zhang H, Song X, Zhou Z, Yang J, Qiu L, Wang L, Song L. Fish Shellfish Immunol. 2011 Mar;30(3):836-44. A primitive Toll-like receptor signaling pathway in mollusk Zhikong scallop Chlamys farreri. Wang M, Yang J, Zhou Z, Qiu L, Wang L, Zhang H, Gao Y, Wang X, Zhang L, Zhao J, Song L. Dev Comp Immunol. 2011 Apr;35(4):511-20. A dopamine beta hydroxylase from Chlamys farreri and its induced mRNA expression in the haemocytes after LPS stimulation. Zhou Z, Wang L, Yang J, Zhang H, Kong P, Wang M, Qiu L, Song L. Fish Shellfish Immunol. 2011 Jan;30(1):154-62. A novel scavenger receptor-cysteine-rich (SRCR) domain containing scavenger receptor identified from mollusk mediated PAMP recognition and binding. Liu L, Yang J, Qiu L, Wang L, Zhang H, Wang M, Vinu SS, Song L. Dev Comp Immunol. 2011 Feb;35(2):227-39. A macrophage migration inhibitory factor like gene from scallop Chlamys farreri: Involvement in immune response and wound healing. Li F, Huang S, Wang L, Yang J, Zhang H, Qiu L, Li L, Song L. Dev Comp Immunol. 2011 Jan;35(1):62-71. The second anti-lipopolysaccharide factor (EsALF-2) with antimicrobial activity from Eriocheir sinensis. Zhang Y, Wang L, Wang L, Yang J, Gai Y, Qiu L, Song L. Dev Comp Immunol. 2010 Sep;34(9):945-52. AiC1qDC-1, a novel gC1q-domain-containing protein from bay scallop Argopecten irradians with fungi agglutinating activity. Kong P, Zhang H, Wang L, Zhou Z, Yang J, Zhang Y, Qiu L, Wang L, Song L. Dev Comp Immunol. 2010 Aug;34(8):837-46. Cflec-5, a pattern recognition receptor in scallop Chlamys farreri agglutinating yeast Pichia pastoris. Zhang H, Kong P, Wang L, Zhou Z, Yang J, Zhang Y, Qiu L, Song L. Fish Shellfish Immunol. 2010 Jul;29(1):149-56. AiCTL-6, a novel C-type lectin from bay scallop Argopecten irradians with a long C-type lectin-like domain. Zhang H, Song X, Wang L, Kong P, Yang J, Liu L, Qiu L, Zhang Y, Qiu L, Song L. Fish Shellfish Immunol. 2011 Jan;30(1):17-26. The construction of a cDNA library enriched for immune genes and the analysis of 7535 ESTs from Chinese mitten crab Eriocheir sinensis. Gai Y, Wang L, Zhao J, Qiu L, Song L, Li L, Mu C, Wang W, Wang M, Zhang Y, Yao X, Yang J. Fish Shellfish Immunol. 2009 Dec;27(6):684-94. The involvement of suppressors of cytokine signaling 2 (SOCS2) in immune defense responses of Chinese mitten crab Eriocheir sinensis. Zhang Y, Zhao J, Zhang H, Gai Y, Wang L, Li F, Yang J, Qiu L, Song L. Dev Comp Immunol. 2010 Jan;34(1):42-8.