胡有天 - 上海交通大学 - 系统生物医学研究院

个人简介

学习经历 2003.09-2007.06 天津师范大学，化学与生命科学学院，生物科学专业，学士。 2007.09-2012.12 武汉大学，生命科学学院，微生物学专业，博士(硕博连读)。工作经历 2013.08-2014.08 美国约翰斯霍普金斯大学医学院。博士后，从事嗜酸性粒细胞食管炎痛觉过敏的机制研究。 2014.11-现在上海交通大学,系统生物医学研究院。助理研究员，从事胱硫醚-γ裂解酶CSE、鞘氨醇-1磷酸裂解酶SPL等靶点蛋白的小分子抑制剂开发。

研究领域

1.重大疾病靶点蛋白的新型高效分子探针或抑制剂的设计和发现。2.利用抑制剂作为工具，研究靶点蛋白在疾病发生中的作用。

近期论文

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(1) Youtian Hu, Xiaoyun Yu, Shaoyong Yu.* QX-314 inhibits acid-induced activation of esophageal nociceptive C fiber neurons. Neurogastroenterology & Motility 2019;e13543. (Epub ahead of print) (2) Youtian Hu, # Lu Wang, # Xu Han, # Yueyang Zhou, Tonghui Zhang, Li Wang, Ting Hong, Wei Zhang, Xun-Xiang Guo, Jielin Sun, Yingxing Qi, Jing Yu, * Hong Liu, * and Fang Wu.* Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine γ-Lyase. Journal of Medicinal Chemistry 2018. (Epub ahead of print) (3) Youtian Hu, Juan Feng, Fang Wu.* The Multiplicity of Polypeptide GalNAc-Transferase: Assays, Inhibitors and Structures. ChemBioChem 2018, 19(24):2503-2521. (4) ZongYun Chen,# Youtian Hu,# Wei Shan Yang, Ya Wen He, Jing Feng, Bin Wang, Rui Ming Zhao, Jiu Ping Ding, ZhiJian Cao, WenXin Li,* YingLiang Wu.* Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family. The Journal of Biological Chemistry 2012, 287(17):13813-13821. (5) Zongyun Chen,# Youtian Hu,# Jun Hu, # Weishan Yang, Jean-Marc Sabatierd, Michel De Waarde, Zhijian Cao, Wenxin Li, Song Han*, Yingliang Wu*.Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues. Biochemical and Biophysical Research Communications 2014, 447(1):70-76. (6) Jing Feng,# Youtian Hu,# Hong Yi,# Shijin Yin, Song Han, Jun Hu, Zongyun Chen, Weishan Yang, Zhijian Cao, Michel De Waard, Jean-Marc Sabatier, Wenxin Li and Yingliang Wu*. Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. The Journal of Biological Chemistry 2013, 288(18):12544-12553. (7) Zongyun Chen,# Youtian Hu,# Jing Hong,# Jun Hu, Weishan Yang, Fang Xiang, Fan Yang, Zili Xie, Zhijian Cao, Wenxin Li, Donghai Lin,* and Yingliang Wu.*Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel. Scientific Reports 2015, 5:9881. (8) Youtian Hu,# Zhenyu Liu,# Xiaoyun Yu, Pankaj J. Pasricha, Bradley J. Undem, and Shaoyong Yu*. Increased acid responsiveness in vagal sensory neurons in a guinea pig model of eosinophilic esophagitis. American journal of physiology Gastrointestinal and liver physiology 2014, 307(2):G149-157. (9) Zhenyu Liu,# Youtian Hu,# Xiaoyun Yu, Jiefeng Xi, Xiaoming Fan, Chung-Ming Tse, Allen C. Myers, Pankaj J. Pasricha, Xingde Li, and Shaoyong Yu*. Allergen challenge sensitizes TRPA1 in vagal sensory neurons and afferent C-fiber subtypes in guinea pig esophagus. American journal of physiology Gastrointestinal and liver physiology 2015, 308(6):G482-488. (10) Xiaoyun Yu,# Youtian Hu,# Fei Ru, Marian Kollarik, Bradley J. Undem, and Shaoyong Yu*. TRPM8 function and expression in vagal sensory neurons and afferent nerves innervating guinea pig esophagus. American journal of physiology Gastrointestinal and liver physiology 2015, 308(6):G489-496. (11) Youtian Hu,# Jing Chen, # Bin Wang, # Weishan Yang, Chuangeng Zhang, Jun Hu, Zili Xie, Zhijian Cao, Wenxin Li, Yingliang Wu*, Zongyun Chen*. Engineering a peptide inhibitor towards the KCNQ1/KCNE1 potassium channel (IKs). Peptides 2015, 71:77-83.