王兰 - 上海交通大学 - 系统生物医学研究院

个人简介

学习经历 2004. 9-2010. 7，复旦大学，遗传学，博士 2000. 9-2004. 7，合肥工业大学，生物工程，学士工作经历 2014. 3-至今, 上海交通大学, 系统生物医学研究院, 副研究员 2011. 8-2013.10, Mayo Clinic College of Medicine, Rochester, MN, USA, Department of Biochemistry and Molecular Biology, Postdoctoral research fellow 2011. 3-2011. 7, New York State University at Stony Brook, NY, USA, Department of Pathology, Postdoctoral research fellow

研究领域

肿瘤发生和发展的分子机制研究

近期论文

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1) Q. Wang, S. Bu, D. Xin, B. Li, L. Wang and D. Lai, Autophagy Is Indispensable for the Self-Renewal and Quiescence of Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties, Oxidative Medicine And Cellular Longevity, 10.1155/2018/7010472, 2018. 2) Y- He*, Yu Zhao*, Lan Wang*, Laura R. Bohrer, Yunqian Pan, Liguo Wang, Haojie Huang, LSD1 promotes S-phase entry and tumorigenesis via chromatin co-occupation with E2F1 and selective H3K9 demethylation. Oncogene. 2018 Jan 25;37(4):534-543. Doi: 10.1038/onc.2017.353. 3) Xianbin Su*, Yi Shi*, Xin Zou*, Zhao-Ning Lu*, Gangcai Xie, Jean Y.H. Yang, Chong-Chao Wu, Xiao-Fang Cui, Kun-Yan He, Qing Luo, Yu-lan Qu, Na Wang, Lan Wang, Ze-Guang Han*. Single-cell RNA-Seq analysis reveals dynamic trajectories during mouse liver development, BMC Genomics, 2017 Dec 4;18(1):946. 4) Sheng Cheng*, Lan Wang*#, Chuanhuai Deng, Shi-Chun Du, Ze-Guang Han, ARID1A represses hepatocellular carcinoma cell proliferation and migration through lncRNA MVIH. Biochem Biophys Res Commun. 2017 Sep 9;491(1): 178-182. 5) Rui Gao, Lan Wang, Hao Cai, Jingjing Zhu, Long Yu. E3 ubiquitin ligase RLIM negatively regulates c-Myc transcriptional activity and restrains cell proliferation. PLOS ONE. 2016 Sep 29; 11(9):e0164086. 6) Bing-Hao Wu, Hui Chen, Chun-Miao Cai, Jia-Zhu Fang, Chong-Chao Wu, Li-Yu Huang, Lan Wang and Ze-Guang Han. Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A. Oncotarget. 2016 Feb 9;7(6):6847-63. 7) Lan Wang*, Xianzhuo Zeng*, Shuai Chen*, Liya Ding, Jian Zhong, Jonathan C Zhao, Liguo Wang, Aaron Sarver, Antonius Koller, Jizu Zhi, Yupo Ma, Jindan Yu, Junjie Chen and Haojie Huang#. BRCA1 is a negative modulator of the PRC2 complex. EMBO J. 2013. 32; 1584-1597. 8) Lan Wang* and Haojie Huang. EZH2 takes the stage when BRCA1 loses. Cell Cycle. 2013 Dec. 1; 12(23):3575-6. 9) Lan Wang*, Guifen He, Pingzhao Zhang, Xiang Wang, Mei Jiang, Long Yu. Interplay between MDM2, MDMX, Pirh2 and COP1-the Negative Regulators of p53. Mol Biol Rep. 2011. 38 (6): 229-36. 10) Lan Wang*, Rui Gao, Long Yu. Combined analysis of association between p73 G4C14-to-A4T14 polymorphisms and cancer risk. Mol Biol Rep. 2012. Feb; 39(2):1731-8. 11) Guifen He, Qian Wang, Yuqi Zhou, Xiaohua Wu, Lan Wang, Nadire Duru, Xiangtao Kong, Pingzhao Zhang, Bo Wan, Long Sui, Qisang Guo, Jian-Jian Li and Long Yu. 2011. YY1 is a novel potential therapeutic target for the treatment of HPV infection-induced cervical cancer by arsenic trioxide. Int J Gynecol Cancer, 21 (6): 1097-1104. 12) Qian Wang, Ying Yang, Lan Wang, Pingzhao Zhang, Long Yu. 2008. Acidic domain is indispensable for MDM2 to negatively regulate the acetylation of p53. Biochem Biophys Res Commun. 26;374(3): 437-41.