郭勋祥 - 上海交通大学 - 系统生物医学研究院

个人简介

学习经历 2005-2008 日本京都大学博士 2001-2004 华东理工大学硕士 1993-1997 南京化工大学学士工作经历 2012-至今系统生物医学研究院副研究员 2010-2011 系统生物医学研究院助理研究员 2008-2010 日本东京大学博士后

研究领域

1. 生物活性小分子的高效合成2. 小分子抑制剂的设计与合成

近期论文

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1. Zhe-Yao Hu, Yan Zhang, Xin-Chang Li, Jing Zi, Xun-Xiang Guo*. Pd-Catalyzed Intramolecular Chemoselective C(sp2)-H and C(sp3)-H Activation of N-Alkyl-N-arylanthranilic Acids. Organic Letters, 2019, 21, 989-992. (*通讯作者) 2.Yan Zhang, Zhe-Yao Hu, Xin-Chang Li, Xun-Xiang Guo*. Cu-Catalyzed Decarboxylative N-Arylation of Indole-2-carboxylic Acids. Synthesis, 2019, DOI: 10.1055/s-0037-1611946. (In press) (*通讯作者) 3. Youtian Hu, Lu Wang, Xu Han, Yueyang Zhou, Tonghui Zhang, Li Wang, Ting Hong, Wei Zhang, Xun-Xiang Guo, Jielin Sun, Yingxing Qi, Jing Yu*, Hong Liu*, Fang Wu*. Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine γ-Lyase. Journal of Medicinal Chemistry, 2019, 62, 1677-1683. 4. Jing Zi, Da-Wei Gu, Yan Zhang, Zhe-Yao Hu, Xing-Quan Zhang, Xun-Xiang Guo*. Synthesis of Quinoxalines via Iodine-Catalyzed One-Pot Annulation of Alkynes with o-Phenylenediamines. Synthetic Communications, 2018, 48, 915-920. (*通讯作者) 5. Ning Xu, Da-Wei Gu, Jing Zi, Xin-Yan Wu, Xun-Xiang Guo*. Enantioselective Synthesis of 3-Alkynyl-3-hydroxyindolin-2-ones by Copper-Catalyzed Asymmetric Addition of Terminal Alkynes to Isatins. Organic Letters, 2016, 18, 2439-2442. (*通讯作者) (Highlighted by Synfacts 2016, 12, 704.) 6. Xun-Xiang Guo*, Da-Wei Gu, Zhengxing Wu, Wanbin Zhang*. Copper-Catalyzed C-H Functionalization Reactions: Efficient Synthesis of Heterocycles. Chemical Reviews, 2015, 115, 1622-1651. (*通讯作者) 入选“2015年中国百篇最具影响国际学术论文”。 7. Da-Wei Gu, Xun-Xiang Guo*. Synthesis of N-Arylcarboxamides by the Efficient Transamidation of DMF and Derivatives with Anilines. Tetrahedron 2015, 71, 9117-9122. (*通讯作者) 8. Ning Xu , Da-Wei Gu , Yan-Sheng Dong , Feng-Ping Yi , Liangzhen Cai , Xin-Yan Wu*, Xun-Xiang Guo*. Copper-Catalyzed Synthesis of 1,2-Diketones via Oxidation of Alkynes. Tetrahedron Letters, 2015, 56, 1517-1519. (*通讯作者) 9. Da-Wei Gu, Xun-Xiang Guo*. Copper-Catalyzed Annulation of Heteroaromatic β-Iodo-α,β-unsaturated Carboxylic Acids with Alkynes for the Synthesis of Indolo[2,3-c]pyrane-1-ones and Thieno[2,3-c]pyrane-7-ones. Organic & Biomolecular Chemistry, 2014, 12, 6114-6120. (*通讯作者) 10. Xun-Xiang Guo*. Synthesis of Isocoumarin Derivatives by Copper-Catalyzed Addition of o-Halobenzoic Acids to Active Internal Alkynes. The Journal of Organic Chemistry, 2013, 78, 1660-1664. (*通讯作者)