个人简介
Deng Yuliang, Ph.D., Associate Professor. His research interests focus on precision diagnosis and personalized therapy based on micro-clininc human samples, mainly using microfluidic chip technology for 1）Rare cell (such as circulating tumor cells) seperation in blood, 2）Single cell gene detection and protein analysis, 3）Tumor microenvironment simulation and organ on a chip system construction, 4）Real-time POCT（Point-of-care testing）detection. His research were supported by National Natural Science Foundation of China （NSFC）, Shanghai Natural Science Foundation, the Doctoral Fund of the Ministry of Education, and the Open Fund of the Key Laboratory of the Ministry of Education. He also participated in the National Key Research and Development Program “Precision Medical Research” and other important projects. He has been granted four invention patents and had applied one PCT patent. His related work were published in academic journals such as PNAS, Advanced Materials, Lab on a chip, Analytical Chemistry, Scientific Reports, Analyst, Microfluidics and nanofluidics.
Research Interests: 1. CTC (circulating tumor cells) separation in blood based on biochip and nanostructure material; 2.Single cell gene detection and protein analysis based on microfluidic chip; 3.Tumor microenvironment simulation and organ on a chip construction based on chip technology； 4.Real-time POCT（Point-of-care testing）development；
邓宇亮，博士，副研究员，硕士生导师。研究方向聚焦于微量临床人体样本的个体化精准诊断与治疗相关研究，主要利用微流控芯片技术进行血液中稀有细胞分选、单细胞基因组与蛋白组研究、肿瘤微环境与类器官芯片构建、POCT即时检测等。主持国家自然科学基金、上海市自然科学基金、教育部博士点基金、教育部重点实验室开放基金等项目；参与国家重点研发计划“精准医学研究”等项目。获授权发明专利4项，申请PCT专利1项，相关工作发表在PNAS，Advanced Materials，Lab on a chip，Analytical Chemistry， Scientific Reports ，Analyst ，Microfluidics and nanofluidics等学术期刊。
PATENTS
1. Method for separating circulating tumor cells from blood, 2016.6.29, China, CN201310546026.1
2. Method for isolating high-purity circulating tumor cells from blood, 2016.8.17, China, CN201310547812.3
3. Microfluidic screening chip based on ultrasonic standing wave and its preparation method, 2012.5.2, China, CN201010519669.3
4. Microfluidic chip for microcapsule generation, 2012.8.8, China, CN201010526187.0
近期论文
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1. Wang, M.; Wang, Z.; Zhang, M.; Guo, W.; Li, N.; Deng, Y*.; Shi, Q*. Journal of Materials Chemistry B 2017, 5, 9114-9120. (*Corresponding author)
2. Tang, Y.; Wang, Z.; Li, Z.; Kim, J.; Deng, Y.; Li, Y.; Heath, J. R.; Wei, W.; Lu, S.; Shi, Q. Proceedings of the National Academy of Sciences 2017, 114, 2544-2549.
3. Yang, L.; Wang, Z.; Deng, Y.; Li, Y.; Wei, W.; Shi, Q. Anal. Chem. 2016, 88, 11077-11083.
4. Wang, Z.; Wu, W.; Wang, Z.; Tang, Y.; Deng, Y.; Xu, L.; Tian, J.; Shi, Q., Ex vivo expansion of circulating lung tumor cells based on one-step microfluidics-based immunomagnetic isolation. Analyst 2016, 141, 3621-3625.
5. Zhang, Y.; Tang, Y.; Sun, S.; Wang, Z.; Wu, W.; Zhao, X.; Czajkowsky, D. M.; Li, Y.; Tian, J.; Xu, L.; Wei, W.; Deng, Y.*; Shi, Q*., Single-Cell Codetection of Metabolic Activity, Intracellular Functional Proteins, and Genetic Mutations from Rare Circulating Tumor Cells. Anal. Chem. 2015, 87 (19), 9761-9768. (*Corresponding author)
6. Deng, Y.; Zhang, Y.; Sun, S.; Wang, Z.; Wang, M.; Yu, B.; Czajkowsky, D. M.; Liu, B.; Li, Y.; Wei, W.; Shi, Q., An Integrated Microfluidic Chip System for Single-Cell Secretion Profiling of Rare Circulating Tumor Cells. Scientific Reports 2014, 4, 7499
7. Liu, K.*; Zhang, N.G.; Wang, S.X.; Deng, Y*., An automatic microfluidic sample transfer and introduction system. Microfluid. Nanofluid. 2014, 16 (1), 101-108. (*Corresponding author)
8. Cheng, B.; He, Z.; Zhao, L.; Fang, Y.; Chen, Y.; He, R.; Chen, F.; Song, H.; Deng, Y.; Zhao, X., Transparent, biocompatible nanostructured surfaces for cancer cell capture and culture. International journal of nanomedicine 2014, 9, 2569-2579.
9. Sadeghi, S.; Liang, V.; Cheung, S.; Woo, S.; Wu, C.; Ly, J.; Deng, Y.; Eddings, M.; van Dam, R. M., Reusable electrochemical cell for rapid separation of [18F] fluoride from [18O] water for flow-through synthesis of 18F-labeled tracers. Applied radiation and isotopes 2013, 75, 85-94.
10. Zhang, N.#; Deng, Y#.; Tai, Q.; Cheng, B.; Zhao, L.; Shen, Q.; He, R.; Hong, L.; Liu, W.; Guo, S.; Liu, K.; Tseng, H.-R.; Xiong, B.; Zhao, X.-Z., Electrospun TiO2 Nanofiber-Based Cell Capture Assay for Detecting Circulating Tumor Cells from Colorectal and Gastric Cancer Patients. Adv. Mater. 2012, 24 (20), 2756-2760. (# Co-first author)
11. Liu, K#.; Deng, Y.#; Zhang, N..; Li, S. Z.; Ding, H. J.; Guo, F.; Liu, W.; Guo, S. S.; Zhao, X. Z., Generation of disk-like hydrogel beads for cell encapsulation and manipulation using a droplet-based microfluidic device. Microfluid. Nanofluid. 2012, 13 (5), 761-767. (# Co-first author)
12. Deng, Y.; Zhang, N.; Zhao, L.; Yu, X.; Ji, X.; Liu, W.; Guo, S.; Liu, K.; Zhao, X.-Z., Rapid purification of cell encapsulated hydrogel beads from oil phase to aqueous phase in a microfluidic device. Lab Chip 2011, 11 (23), 4117-4121.
学术兼职
Academic Organizations
Member: Chinese Society of Biomedical Engineering
Member: Shanghai Society of Microscopy
Journal Reviewer
Lab on a chip, RSC Advance, Scientific reports, Microfluidics and nanofluidics, Polymer testing, Genetics
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