张冰 - 上海交通大学 - 系统生物医学研究院

个人简介

学习经历 1996-2001年潍坊医学院临床医学学士 2001-2006年山东大学医学院博士（优秀博士生）工作经历 2006-2010 博士后，佐治亚大学生化与分子生物学系，复合多糖研究中心。美国 2010-2011 博士后, 哈佛大学波士顿儿童医院，美国。 2011-2015 讲师，哈佛大学医学院，哈佛大学波士顿儿童医院, 美国。 2015- 研究员，上海交通大学系统生物与医学研究院。 2017- 上海交通大学附属新华医院兼聘首席科学家

研究领域

1. 心血管系统发育与重大疾病关键分子机制2. 表观遗传与转录的分子调控网络3. 高通量测序技术研制和生物信息学软件及分析程序开发

近期论文

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1. Zhang Y, Liu XX, Zhang B, et al. (2004) Inhibition of prostate cancer cell PC-3 by rAd-ODC/Ex3as. Journal of Shandong University, 42(5):423 2. Zhang B, Liu XX, Gong L. (2004) The development of antisense technology(review). Oncology Section Foreign Medical Sciences.31 (9):674 3. Zhang B, Liu XX, Zhang Y, et al. (2005) The screening of the sensitive antisense targets in the ODC mRNA. Chinese Journal of Current Advances in General Surgery, 8(5):146 4. Zhang B, Liu XX, Zhang Y, et al. (2005) Construction of an antisense bicistronic recombinant adenovirus vector of ODC and SAMDC. Journal of Shandong University, 43(5):345 5. Zhang Y, Liu XX, Zhang B, et al. (2005) inhibition of Prostate Cancer Cells with Antisense RNA of Ornithine Decarboxylase Gene in Vitro. Chinese Journal of Biochemistry and Molecular biology, 21(1): 128 6. Hu HY, Liu XX, Zhang B et al. (2005) Ornithine decarboxylase gene is overexpressed in colorectal carcinoma. World J Gastroenterol April; 11 (15):2244-2248 7. Zhang Y, Liu XX, Zhang B, Hu HY, Gong L. (2005) Antitumor effect of antisense ODC adenovirus on human prostate cancer cells. Prostate Cancer Prostatic Dis.;8(3):280-6 8. Zhang B, Liu XX, Zhang Y, Jiang CY, Hu HY, Gong L, Liu M, Teng QS. (2006) Polyamine depletion by ODC-AdoMetDC antisense adenovirus impairs human colorectal cancer growth and invasion in vitro and in vivo. J Gene Med. Aug;8(8):980-9. 9. Zhang B, Liu XX, Zhang Y, Jiang CY, Teng QS, Hu HY, Wang W, Gong L. (2006)Adenovirus-mediated expression of both antisense ODC and AdoMetDC inhibited colorectal cancer cell growth in vitro. Acta Pharmacol Sin. Mar;27(3):353-9 10. Gong L, Jiang C, Zhang B, Hu H, Wang W, Liu X. (2006) Adenovirus-mediated expression of both antisense ornithine decarboxylase and s-adenosylmethionine decarboxylase induces G1 arrest in HT-29 cells. J Biochem Mol Biol. Nov 30;39(6):730-6. 11. Gong L, Zhang B, Zhang Y, Hu H, Zhao Z, Liu X. (2007) Cloning, expression and purification of human S-adenosylmethionine decarboxylase gene alpha subunit. Chin J Physiol. Feb 28;50(1):29-33. 12. Tian H, Liu X, Zhang B, Sun Q, Sun D. (2007) Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth. Acta Biochim Biophys Sin (Shanghai). Jun;39(6):423-30. 13. Song X, Tian H, Liu XX, Zhang B, Li WJ, Xu J. (2008) Ornithine Decarboxylase and S-adenosylmethionine Decarboxylase Bi-antisense Virus Inhibit Growth and Invasion of Esophageal Cancer Cell Line Eca109. Ai Zheng. Nov;27(11):1144-9. Chinese. 14. Zhang Bing, Ursula M. Dietrich, Jian-Guo Geng, Roy Bicknell, Jeffrey D.Esko and Lianchun Wang. (2009) Repulsive axon guidance molecule Slit3 is a novel angiogenic factor. Blood. 2009 Nov 5;114(19):4300-9 （IF>13) 15. Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise A, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT.Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest. 2011 May 2;121(5):1894-904. （IF>12) 16. He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou D, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, Pu WT. Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart. Circ Res. 2012 Feb 3;110(3):406-15. （IF>14) 17. Bing Zhang, Daniel S. Day, Joshua W. Ho, Lingyun Song, Jingjing Cao, Danos Christodoulou, Jonathan G. Seidman, Gregory E. Crawford, Peter J. Park, and William T. Pu. A dynamic H3K27ac signature defines VEGFA-regulated endothelial enhancers. Genome Res. 2013 Jun;23(6):917-27. （IF>12) 18. Zhang Bing, Pu WT. The mysterious origins of coronary vessels. Cell Res. 2013 Jul 9.doi:10.1038/ cr. 2013.90. （IF>14) 19. Zhang Bing, Wenyuan Xiao, Hong Qiu, Fuming Zhang, Eduard Condac, Cathy Cheng, Parastoo Azadi, John J. Greer, Dean Li, kelley Moremen, Robert Linhardt, Jeffrey D. Esko, Lianchun Wang. Congenital Diaphragmatic Hernia Results From Disruption of Developmental Angiogenesis mediated by Slit3-Robo4-Heparan Sulfate Signaling. J Clin Invest. 2014 Jan 2;124(1):209-21. （IF>12) 20. Zhang Bing, William. T. PU. Notching up vascular regeneration. Cell Research 2014; doi:10.1038/cr.2014. （IF>14)