个人简介
学习经历 复旦大学药理学学士, 上海交通大学遗传学博士(2013) 工作经历 1.上海交通大学,系统生物医学研究院,研究员、博士生导师 (2018.1-) 2.Harvard Medical School,Postdoc (2015-2017) 3.国家人类基因组南方研究中心,助理研究员,副研究员
研究领域
1.泛素化修饰异常(ubiquitination)与肿瘤的发生发展 2.胃印戒细胞癌(signet-ring cell carcinoma)的发病机制
近期论文
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(1) Huang LY#,*, Zhao J#, Chen H, Wan L, Inuzuka H, Guo J, Fu X, Zhai Y, Lu Z, Wang X, Han ZG, Sun Y*, Wei W*. SCFFBW7-mediated Degradation of Brg1 Suppresses Gastric Cancer Metastasis. Nat Commun. 2018 (#First author,*Corresponding author) (IF=12.3) (2) Huang LY#, Wang X#, Cui XF#, Li H, Zhao J, Wu CC, Min L, Zhou Z, Wan L, Wang YP, Zhang C, Gao WQ, Sun Y, Han ZG. IRTKS is correlated with progression and survival time of gastric cancer patients. Gut. 2018 Aug;67(8):1400-1409. doi: 10.1136/gutjnl-2016-313478. (#First author) (IF=17.0) (3) Wan L†, Xu K†, Wei Y†, Zhang J†, Han T, Fry C, Zhang Z, Wang V, Huang LY, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Wu Y, Liu J, Jin VX, Li J, Dai X, Guo J, Liu J, Asara JM , Brown M, Huang MC, Wei W. Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. Mol Cell. 2018 Jan 18;69(2):279-291.e5. doi: 10.1016/j.molcel.2017.12.024. ( IF=14.2)