达林泰 - 上海交通大学 - 系统生物医学研究院

个人简介

学习经历 2005-2010 Ph.D. in Physical Chemistry with Prof. Yun-Dong Wu, Peking University. 2001-2005 B.Sc in Chemistry, Inner Mongolia University. 工作经历 2017.1-now Shanghai Jiaotong University 2014.05-2015.11 Postdoctoral with Prof. Huan-Xiang Zhou in Florida State University. 2013.09-2014.05 Postdoctoral with Prof. Xuhui Huang in Chemistry Department, Hong Kong University of Science and Technology. 2013.03-2013.09 Visiting scholar with Prof. Dong Wang in University of California, San Diego. 2010-2013.02 Postdoctoral with Prof. Xuhui Huang in Chemistry Department, Hong Kong University of Science and Technology.

研究领域

1. 计算机模拟生物大分子机器2. 天然产物生物合成机制及药物功能研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Lin-Tai Da*, Jin Yu Base-Flipping Dynamics from an Intrahelical to an Extrahelical State Exerted by Thymine DNA Glycosylase During DNA Repair Process. Nucleic Acids Research 2018 46, 5410-5425 (corresponding author). 2. Lin-Tai Da*, Yi Shi, Guodong Ning, Jin Yu*. Dynamics of the Excised Base Release in Thymine DNA Glycosylase during DNA Repair Process. Nucleic Acids Research 2018 46, 568-581 (corresponding author). 3. Lin-Tai Da*, Chao E, Yao Shuai, Shaogui Wu, Xiao-Dong Su, and Jin Yu*. T7 RNA polymerase translocation is facilitated by a helix opening on the fingers domain that may also prevent backtracking. Nucleic Acids Research 2017 45, 7909-7921 (corresponding author). 4. Lin-Tai Da, Fátima Pardo-Avila, Liang Xu, Daniel-Adriano Silva, Lu Zhang, Xin Gao, Dong Wang, Xuhui Huang. Bridge Helix Bending Promotes RNA Polymerase II Backtracking Through a Critical Threonine Residue. Nat. Commun. 2016 DOI: 10.1038/ncomms11244. 5. Lin-Tai Da, Chao E, Baogen Duan, Chuanbiao Zhang, Xin Zhou, Jin Yu. A Jump-from-Cavity Pyrophosphate Ion Release Assisted by a Key Lysine Residue in T7 RNA Polymerase Transcription Elongation. PLoS. Comp. Bio. 2015 11(11): e1004624. 6. Lin-Tai Da, Sheong, F.K., Silva, D., Huang, X. "Application of Markov State Models to Simulate Long Timescale Dynamics of Biological Macromolecules", Book Chapter, Protein Conformational Dynamics, Advances in Experimental Medicine and Biology. 805, 29-66, Springer, (2014) (Book Chapter). 7. Jin Yu, Lin-Tai Da, Xuhui Huang. Constructing kinetic models to elucidate structural dynamics of a complete RNA polymerase II elongation cycle. Physical Biology. 2015 102, 016004 8. Baogen Duan, Shaogui Wu, Lin-Tai Da, Jin Yu. A critical residue selectively recruits nucleotides for T7 RNA polymerase transcription fidelity control. Biophysical Journal. 2014 107, 2130-2140. 9. Xu, L., Lin-Tai Da, Plouffe, S.W., Chong, J., Kool, E., Wang, D. Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis. DNA Repair. 2014 19 71-83. 10. Changsun Eun, Juan Manuel Ortiz-Sánchez, Lin-Tai Da, Dong Wang, J Andrew McCammon. Molecular dynamics simulation study for the conformation of TFIIS and the insertion of the catalytic domain of TFIIS into RNA Polymerase II. PLoS One. 2014, 9(5): e97975. 11. Daniel-Adriano Silva, Dahlia Weiss, Fátima Pardo-Avila, Lin-Tai Da, Michael Levitt, Dong Wang, and Xuhui Huang. Millisecond Dynamics of RNA Polymerase II Translocation at Atomic Resolution. Proc. Nat. Acad. Sci. U.S.A. 2014 111(21): 7665-7670. Recommended on Faculty of 1000 Prime 12. Pardo-Avila, Fátima, Lin-Tai Da, Ying Wang, and Xuhui Huang. Theoretical Investigations on Elucidating Fundamental mechanisms of catalysis and dynamics involved in transcription by RNA polymerase. J. Theor. Comput. Chem. 2013 12(8): 1341005. 13. Lin-Tai Da, Pardo-Avila, Fátima, Dong Wang, and Xuhui Huang. A Two-State Model for the Dynamics of the Pyrophosphate Ion Release in Bacterial RNA Polymerase. PLoS. Comp. Bio. 2013 9(4): e1003020. Recommended on Faculty of 1000 Prime 14. Lin-Tai Da, Dong Wang, and Xuhui Huang. Dynamics of Pyrophosphate Ion Release and Its Coupled Trigger Loop Tip Motion from Closed to Open State in RNA Polymerase II. J. Am. Chem. Soc. 2012 134, 2399−2406. Recommended on Faculty of 1000 Prime 15. Yuning Hong, Luming Meng, Sijie Chen, Chris Wai Tung Leung, Lin-Tai Da, Mahtab Faisal, Daniel-Adriano Silva, Jianzhao Liu, Jacky Wing Yip Lam, Xuhui Huang, and Ben Zhong Tang. Monitoring and Inhibition of Insulin Fibrillation by a Small Organic Fluorogen with Aggregation-Induced Emission Characteristics. J. Am. Chem. Soc. 2012 134, 1680-1689. 16. Lin-Tai Da, and Yun-Dong Wu. Theoretical Studies on the Interactions and Interferences of HIV-1 Glycoprotein gp120 and Its Coreceptor CCR5. J. Chem. Inf. Model. 2011 51, 359–369. 17. Lin-Tai Da, Jun-Min Quan and Yun-Dong Wu. Understanding the Binding Mode and Function of BMS-488043 Against HIV-1 Viral Entry. Proteins. 2011 79, 1810–1819. 18. Lin-Tai Da, Jun-Min Quan and Yun-Dong Wu. Understanding of the Bridging Sheet Formation of HIV-1 Glycoprotein gp120. J. Phys. Chem. B. 2009 113, 14536–14543.