洪亮 - 上海交通大学 - 自然科学研究院

个人简介

工作经历 2022-至今上海交通大学药学院双聘教授 2015-至今上海交通大学物理与天文学院&自然科学研究院特聘教授，博士生导师 2010-2014 美国橡树岭国家实验室，博士后（Jeremy C. Smith）教育经历 2006-2010 美国阿克伦大学高分子科学系，博士(导师: Alexei P. Sokolov) 2004-2006 香港中文大学物理系，硕士 (导师：郝少康) 2000-2004 中国科学技术大学物理系，本科科研成果获得基金委重点项目，面上项目，上海市科委，教委重大项目，以及头部药企等多项科研资助。累计发表SCI论文50余篇（其中包括20篇高影响力论文：Nature, Nature Physics, Physical Review Letters, PNAS, Science Advances, Nature Communications, JACS, Chemical Science等）。

研究领域

分子生物物理、人工智能生物医药

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Weishu Zhao, Bozitao Zhong, Lirong Zheng, Pan Tan, Yinzhao Wang, Hao Leng, Nicolas de Souza, Zhuo Liu, Liang Hong, and Xiang Xiao. Proteome-wide 3D structure prediction provides insights into the ancestral metabolism of ancient archaea and bacteria. Nature Communications, 13, 7861 (2022). Bingxin Zhou, Outongyi Lv, Kai Yi, Xinye Xiong, Pan Tan, Liang Hong, Yu Guang Wang. Lightweight Equivariant Graph Representation Learning for Protein Engineering. Accepted at NeurIPS Workshop on Machine Learning for Structural Biology, 2022. L. Zheng, H. Lu, B. Zan, S. Li, H. Liu, Z. Liu, J. Huang, Y. Liu, F. Jiang, Q. Liu,* Yan Feng, and L. Hong*. Loosely-packed Dynamical Structures with Partially-melted Surface Being the Key for Thermophilic Argonaute Proteins Achieving High DNA-cleavage Activity. Nucleic Acids Research, gkac565, 2022. Y. Yu, C. Yang, M. Baggioli, A. E. Phillips, A. Zaccone, L. Zhang, R. Kajimoto, M. Nakamura, D. Yu, L. Hong*. The ω3 scaling of the vibrational density of states in quasi-2D nanoconfined solids. Nature Communications, 13, 3649 (2022). L. Zheng, Z. Liu, Q. Zhang*, S. Li, J. Huang, L. Zhang, B. Zan, M. Tyagi, H. Cheng*, T. Zuo, V. G. Sakai, T. Yamada,C. Yang, P. Tan, F. Jiang, H. Chen, W. Zhuang*, L. Hong*. Universal Dynamical Onset in Water at Distinct Material Interfaces. Chem. Sci., 2022, 13, 4341. X. Qian*, D. Han, L. Zheng, J. Chen, M. Tyag, Q. Li, F. Du, S. Zheng, X. Huang*, S. Zhang, J. Shi, H. Huang*, X. Shi, J. Chen, H Qin, J. Bernholc, X. Chen, L. Q Chen, L. Hong*, Q. M. Zhang. High-entropy polymer produces a giant electrocaloric effect at low fields. Nature, 600.7890 (2021): 664-669. Z. Liu, Sara Lemmonds, J. Huang, M. Tyagi, L. Hong* and N. Jain. Entropic Contribution to Enhanced Thermal Stability in the Thermostable P450 CYP119. Proceedings of the National Academy of Sciences,115.43 (2018): E10049-E10058. P. Tan, Y. Liang, Q. Xu, E. Mamontov, J. Li, X. Xing, and L. Hong*. Gradual crossover from subdiffusion to normal diffusion: A many-body effect in protein surface water. Physical Review Letters,120, 248101 (2018). Z. Liu, J. Huang, M. Tyagi, H. O’Neill, Q. Zhang, E. Mamontov, N. Jain, Yujie Wang, Jie Zhang, Jeremy C. Smith, and L. Hong*. Dynamical Transition of Collective Motions in Dry Protein. Physical Review Letters, 119 (2017), 048101.

学术兼职

上海交通大学张江高等研究院人工智能生物医药中心主任（https://zias.sjtu.edu.cn/xsjg1/rgznswyyzx.htm）上海交通大学重庆人工智能研究院副院长（https://www.sjtu.cq.cn/）上海人工智能实验室顾问科学家（http://www.shlab.org.cn/）上海交通大学-金赛药业数字医疗创新实验室主任