肖晗 - 上海交通大学 - 生命科学技术学院

个人简介

2007年获得四川农业大学理学学士学位；2012年获得中国科学院上海生命科学研究院微生物学博士学位；2012-2015年在美国伊利诺伊大学厄巴纳香槟分校从事博士后研究；2015年至今任上海交通大学副研究员。主持来自国家自然科学基金委、教育部、上海市科学技术委员会等各项科研项目，发表SCI论文17篇，其中包括本领域主流期刊Nature Biotechnology, Trends in Biotechnology, Biotechnology Advances, Metabolic Engineering和ACS Synthetic Biology等，他引380余次。2018年，获上海交通大学晨星优秀青年学者副教授支持计划（B类）。

研究领域

目前主要从事抗肿瘤次级代谢物灵芝酸的高效生物合成以及蘑菇真菌基因编辑平台的开发。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zehua Bao, Mohammad HamediRad, Pu Xue, Han Xiao, Ipek Tasan, Ran Chao, Jing Liang and Huimin Zhao* (2018). Genome-scale engineering of Saccharomyces cerevisiae with single nucleotide precision. Nature Biotechnol, doi: 10.1038/nbt.4132. 2. Wen-Fang Wang, Han Xiao* (co-first author) and Jian-Jiang Zhong* (2018). Biosynthesis of a ganoderic acid in Saccharomyces cerevisiae by expressing a cytochrome P450 gene from Ganoderma lucidum. Biotechnol Bioeng, doi: 10.1002/bit.26583. 3. Hao Qin, Han Xiao* (co-first author), Gen Zou, Zhihua Zhou and Jian-Jiang Zhong* (2017). CRISPR-Cas9 assisted gene disruption in the higher fungus Ganoderma species. Process Biochem 56: 57-61. 4. Jie Wang, Han Xiao, Zhigang Qian and Jian-Jiang Zhong* (2017). Bioproduction of antibody-drug conjugate payload precursors by engineered cell factories. Trends Biotechnol 35(5): 466-478. 5. Zhiqiang Du, Yuan Zhang, Zhigang Qian, Han Xiao and Jian-Jiang Zhong* (2017). Combination of traditional mutation and metabolic engineering to enhance ansamitocin P-3 production in Actinosynnema pretiosum. Biotechnol Bioeng 114(12): 2794-2806. 6. Han Xiao* and Jian-Jiang Zhong* (2016). Production of useful terpenoids by higher-fungus cell factory and synthetic biology approaches. Trends Biotechnol 34(3): 242-255. 7. Hao Qin, Junwei Xu, Jianhui Xiao, Yajie Tang, Han Xiao and Jian-Jiang Zhong* (2016). Cell factories of higher fungi for useful metabolite production. Adv Biochem Eng Biotechnol 155: 199-235. 8. Tong Si, Han Xiao (co-first author) and Huimin Zhao* (2015). Rapid prototyping of microbial cell factories via genome-scale engineering. Biotechnol Adv 33(7):1420-1432. 9. Zehua Bao, Han Xiao (co-first author), Jing Liang, Lu Zhang, Xiong Xiong, Ning Sun, Tong Si and Huimin Zhao* (2015). Homology-Integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae. ACS Synth Biol 4(5):585-594. （入选SCI高被引论文） 10. Han Xiao, Zehua Bao and Huimin Zhao* (2015). High throughput screening and selection methods for directed enzyme evolution. Ind Eng Chem Res 54(16): 4011-4020. 11. Han Xiao and Huimin Zhao* (2014). Genome-wide RNAi screen reveals the E3 SUMO-protein ligase gene SIZ1 as a novel determinant of furfural tolerance in Saccharomyces cerevisiae. Biotechnol Biofuels 7:78. 12. Han Xiao, Zengyi Shao, Yu Jiang, Sudhanshu Dole and Huimin Zhao* (2014). Exploiting Issatchenkia orientalis SD108 for succinic acid production. Microb Cell Fact 13:121. 13. Tong Si, Yunzi Luo, Han Xiao and Huimin Zhao* (2014). Utilizing an endogenous pathway for 1-butanol production in Saccharomyces cerevisiae. Metab Eng 22:60-68. 14. Zhilin Li, Han Xiao (co-first author), Weihong Jiang, Yu Jiang* and Sheng Yang* (2013). Improvement of butanol production from xylose mother liquor by engineering the xylose metabolic pathway in Clostridium acetobutylicum EA 2018. Appl Biochem Biotechnol 171(3): 555-568. 15. Han Xiao, Zhilin Li, Yu Jiang, Yunliu Yang, Weihong Jiang, Yang Gu* and Sheng Yang* (2012). Metabolic engineering of D-xylose pathway in Clostridium beijerinckii to optimize solvent production from xylose mother liquid. Metab Eng 14(5): 569-578. 16. Han Xiao, Yang Gu, Yuanyuan Ning, Yunliu Yang, W. J. Mitchell, Weihong Jiang*, Sheng Yang* (2011). Confirmation and elimination of xylose-metabolic bottlenecks in glucose-PTS-deficient Clostridium acetobutylicum to realize simultaneous utilization of glucose, xylose and arabinose. Appl Environ Microbiol 77(22): 7886-7895. 17. Yang Gu, Yu Jiang, Hui Wu, Xudong Liu, Zhilin Li, Jian Li, Han Xiao, Zhaobing Shen, Hongjun Dong, Yunliu Yang, Yin Li, Weihong Jiang and Sheng Yang (2011). Economical challenges to microbial producers of butanol: Feedstock, butanol ratio and titer. Biotechnol J 6(11): 1348-1357.