黄显清 - 上海交通大学 - 生命科学技术学院

个人简介

2005年4月毕业于上海交大生命学院生化与分子生物学专业，获理学博士学位，同年留校工作，07年12月起担任副教授。目前主要从事抗生素合成等微生物次级代谢的分子调控机理与代谢工程、微生物活性物质的基础及应用等方面的研究。作为负责人主持完成863探索导向课题(2007AA02Z215)、国家自然科学基金(30800009)各一项。相关研究成果在Journal of Bacteriology、Gene、Journal of Biotechnology等期刊上发表SCI收录学术论文20多篇。参与研究的“微生物源农药申嗪霉素”项目获得2007年度上海市科技进步一等奖、2011年度高等学校科技进步二等奖。2008年，入选上海交通大学晨星青年学者奖励计划与上海高校选拔培养优秀青年教师。参与编写全国工程硕士核心教材1本，《基因工程：原理、方法与应用》（清华大学出版社，2008年）。

研究领域

（1）抗生素合成等微生物次级代谢的分子调控机理与代谢工程研究；（2）微生物活性物质的基础及应用研究

近期论文

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Wang GH 1, Huang XQ 1, *, Li SN, Huang JF, Wei X, Li YQ, Xu YQ*. (2012) The RNA chaperone Hfq regulates antibiotic biosynthesis in the rhizobacterium Pseudomonas aeruginosa M18. Journal of Bacteriology (In press) (*Corresponding authors, 1Co-first authors) Wu DQ, Ye J, Ou HY, Wei X, Huang XQ, He YW, Xu YQ (2011) Genomic analysis and temperature-dependent transcriptome profiles of the rhizosphere originating strain Pseudomonas aeruginosa M18. BMC Genomics 12:438. Li YQ, Du XL, Lu ZJ, Wu DQ, Zhao YL, Ren B, Huang JF, Huang XQ, Xu YH, Xu YQ (2011) Regulatory Feedback Loop of Two phz Gene Clusters through 5 '-Untranslated Regions in Pseudomonas sp M18. PLoS One 6: e19413. Lu JS 1, Huang XQ 1, *, Li K, Li SN, Zhang MY, Wang Y, Jiang HX, Xu YQ* (2009) LysR family transcriptional regulator PqsR as repressor of pyoluteorin biosynthesis and activator of phenazine-1-carboxylic acid biosynthesis in Pseudomonas sp. M18. Journal of Biotechnology 143(1): 1-9. (*Corresponding authors, 1Co-first authors) Lu JS, Huang XQ *, Zhang MY, Li SN, Jiang HX, Xu YQ (2009) The distinct quorum sensing hierarchy of las and rhl in Pseudomonas sp. M18. Current Microbiology 59(6): 621-627 (*Corresponding authors) Huang JF, Xu YQ, Zhang HY, Li YQ, Huang XQ, Ren B, Zhang XH (2009) Temperature-dependent expression of phzM with its regulatory genes lasI and ptsP in rhizosphere isolated Pseudomonas sp. strain M18. Applied and Environmental Microbiology 75(20): 6568-6580. Huang XQ, Zhang XH, Xu YQ (2008) PltR expression modulated by the global regulators GacA, RsmA, LasI and RhlI in Pseudomonas sp. M18. Research in Microbiology 159(2): 128-136. Huang XQ, Zhang XH, Xu YQ (2008) Positive regulation of pyoluteorin biosynthesis in Pseudomonas sp. M18 by quorum-sensing regulator VqsR. J Microbiol Biotechnol 18: 828-836. Yan A, Huang XQ, Liu HM, Dong DX, Zhang DB, Zhang XH, Xu YQ (2007) An rhl-like quorum-sensing system negatively regulates pyoluteorin production in Pseudomonas sp. M18. Microbiology-SGM 153(1): 16-28. Huang XQ, Yan A, Zhang XH, Xu YQ (2006) Identification and characterization of a putative ABC transporter PltHIJKN required for pyoluteorin production in Pseudomonas sp. M18. Gene 376(1): 68-78. Huang XQ, Zhu DH, Ge YH, Hu HB, Zhang XH, Xu YQ (2004) Identification and characterization of pltZ, a gene involved in the repression of pyoluteorin biosynthesis in Pseudomonas sp. M18. FEMS Microbiol Lett 232: 197-202.