杨选明 - 上海交通大学 - 生命科学技术学院

个人简介

1998.9-2002.7：北京大学生命科学学院理学学士 2002.9-2009.5：中国科学院生物物理研究所感染与免疫研究中心博士 2009.6-2014.6：美国芝加哥大学病理学系博士后 2014.6-2014.10: 美国芝加哥大学助理研究员 2014.11至今：上海交通大学生命科学技术学院特别研究员

研究领域

1.研究肿瘤微环境中的各种细胞组分对肿瘤免疫的抑制机理，发现新的肿瘤治疗靶点； 2.发展基于抗体的靶向肿瘤免疫治疗手段； 3.发展基于T细胞修饰的细胞过继性肿瘤治疗手段； 4.发展基于重组蛋白以及免疫活化的肿瘤疫苗和病原微生物疫苗；

近期论文

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Xuanming Yang, Xunmin Zhang, Yonglian Sun, Tony Tu, Mendy Miller, Yang-Xin Fu. A BTLA-Mediated Bait and Switch Strategy Permits Listeria Expansion in CD8α(+) DCs to Promote Long-Term T Cell Responses. Cell Host & Microbe. 2014 Jul 9;16(1):68-80 Xiaohuan Guo, Ju Qiu, Tony Tu, Xuanming Yang, Liufu Deng, Robert A. Anders, Liang Zhou, Yang-Xin Fu. Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection. Immunity. 2014 Jan 7. pii: S1074-7613(13)00555-4. Xuanming Yang, Xunmin Zhang, May Lynne Fu, Ralph R. Weichselbaum, Thomas F. Gajewski, Yajun Guo, Yang-Xin Fu. Targeting the tumor microenvironment with interferon- bridges innate and adaptive immune responses. Cancer Cell. 2014 Jan 13;25(1):37-48. Ying He, Jikun Zha, Yamin Wang, Wenhua Liu, Xuanming Yang, and Ping Yu. Tissue damage-associated "danger signals" influence T-cell responses that promote the progression of preneoplasia to cancer. Cancer Res. 2013 Jan 15;73(2):629-39. Xuanming Yang, Xunmin Zhang, Eric Mortenson, Olga Radkevich-Brown, Yang Wang, Yang-Xin Fu. Cetuximab-mediated Tumor Regression Depends on Innate and Adaptive Immune Responses. Molecular Therapy. 2013 Jan;21(1):91-100 Xuanming Yang, Eric D Mortenson , Yang-Xin Fu. Targeting and utilizing primary tumors as live vaccines: changing strategies. Cell Mol Immunol. 2011 Nov 21. doi: 10.1038/cmi.2011.49. Qi Da*, Xuanming Yang*, Xiaoqi Li, Youli Xu, Guangxia Gao, Genhong Cheng and Hong Tang. TANK-Binding Kinase 1 Attenuates PTAP-Dependent Retroviral Budding through Targeting Endosomal Sorting Complex Required for Transport-I J Immunol 2011;186;3023-3030 (*, Co-first Author) SaeGwang Park, Zhujun Jiang, Eric D. Mortenson, Liufu Deng, Olga Radkevich-Brown, Xuanming Yang, Husain Sattar, Yang Wang, Nicholas K. Brown, Mark Greene, Yang Liu, Jie Tang, Shengdian Wang, Yang-Xin Fu. The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity. Cancer Cell. 2010 Aug 9;18(2):160-70. Xiaoqi Li, Xuanming Yang, Youli Xu, Xuejun Jiang, Fajun Nan, Hong Tang. Troglitazone inhibits cell proliferation by attenuation of Epidermal Growth Factor Receptor Signaling independent of Peroxisome Proliferator-activated Receptor gamma. Cell Research. 2009: 720-732). Jie Zhao, Xuanming Yang, Sogyong Auh, Kwang Dong Kim, Hong Tang and Yang-Xin Fu. Do adaptive immune cells suppress or activate innate immunity? Trends Immunol. 2009 Jan;30(1):8-12. Jie Zhao, Xuanming Yang, Peishuang Du, Hong Tang. T cells regulate initial inflammatory responses during acute infection. Progress in Biochemistry and Biophysics, 2008, 35(2):129-132 Jie Zhao*, Kwang Dong Kim*, Xuanming Yang*, Sogyong Auh, Yang-Xin Fu , Hong Tang. Hyper innate responses in neonates lead to increased morbidity and mortality after infection. Proc Natl Acad Sci U S A, 2008, May 27;105 (21):7528-33. (*, Co-first Author) Kwang Dong Kim, Jie Zhao, Sogyong Auh, Xuanming Yang, Peishuang Du, Hong Tang &Yang-Xin Fu. Adaptive immune cells temper initial innate responses. Nature Medicine, 2007, Oct;13 (10):1248-52.