当前位置: X-MOL首页全球导师 国内导师 › 肖华

个人简介

肖华,博士,研究员,博士生导师,中共党员,科技部青年科学家。现任国际蛋白质组组织会员、中国蛋白质组学专业委员会委员、青年学者委员会委员,上海市科委自然科学基金评审专家和创新行动计划项目评审专家,教育部青年长江评审专家。 2007年毕业于中国科学院大连化学物理研究所,获分析化学博士学位。自2007年至2013年,先后在美国加州大学欧文分校、加州大学洛杉矶分校和密西根大学安娜堡分校从事研究工作。2013年加盟上海交通大学生命科学技术学院。2014年入选科技部863首批“青年科学家专题”。 近年来,主要围绕生物分离分析新技术和癌症的分子诊断开展研究。发展了复杂蛋白质分离新理论新技术;建立了体液和细胞外泌体分离分析新方法;构筑了亚细胞蛋白质组研究新方法;开拓了无创癌症分子诊断新策略。先后在Mol. Cell. Proteomics,Anal. Chem.,ACS Appl. Mater. Interfaces, Chem. Commun.,Oral Oncol.,Cell. Mol. Life Sci.,Lab Chip,Anal. Chim. Acta,Talanta,J. Proteome Res.,J. Chromatogr. A等国际重要学术期刊发表论文40余篇,SCI他引600余次,其中第一或共同通讯近30篇;申请中国发明专利12项、美国发明专利2项,获得授权6项;参与2本中英文专著章节撰写;担任20余种国际学术期刊论文评阅人。

研究领域

1、生物分离分析新技术新方法研究 围绕生物对象开展分离分析新技术新方法新材料研究,特别是针对蛋白质与核酸的分离新材料等,发展修饰蛋白的分离、定性、定量和结构解析新技术和新方法,为蛋白质组学、蛋白质翻译后修饰及其功能研究提供技术支持。 2、体液与细胞外泌体研究 外泌体在癌症的发生发展过程中起着非常重要的作用,同时也是潜在的癌症诊断标志物和治疗载体。针对体液与细胞外泌体,发展分离分析新技术,开展外泌体蛋白质组及其翻译后修饰研究,拓展外泌体的功能研究与临床应用。 3、癌症分子诊断技术创新 无创分子诊断对癌症的筛查、诊断和治疗非常关键,是生物分离分析的重要研究方向。在已有分离分析新技术新方法以及外泌体研究等技术基础上,结合国家战略需求和实际临床需要,发展用于癌症早期诊断、早期预警和早期干预治疗的新技术新途径。 4、亚细胞蛋白质组研究新方法 随着蛋白质组学研究的深入,迫切需要发展针对亚细胞蛋白质组的分离分析新技术。根据不同亚细胞蛋白质组的特点,结合纳米材料构建亚细胞蛋白质组研究核心方法。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1.Shang, Z. †, Qiao, L.Q. †, Liu, S., Niu, X.M., Qiao, Z., Sun, Y., Zhang, Y., Fan, L.Y., Guan, X.*, Cao, C.X. *, Xiao, H.* Graphene Oxide Facilitated Comprehensive Analysis of Cellular Nucleic Acid Binding Proteins for Lung Cancer. ACS Appl. Mater. Interfaces, 2018, DOI: 10.1021/acsami.8b05428. 2.Sun, Y., Huo, C.H., Qiao, Z., Shang, Z., Uzzaman, A., Liu, S., Jiang, X.T., Fan, L.Y., Ji, L.Y., Guan, X.*, Cao, C.X.*, and Xiao, H.* Comparative proteomic analysis of exosomes and microvesicles in human saliva for lung cancer, J. Proteome Res., 2018, 17(3):1101-1107. 3.Uzzaman, A., Shang, Z., Qiao, Z., Cao, C.X.*, and Xiao, H.* Graphene and graphene oxide serve as solid matrix for extraction of membrane and membrane-associated proteins, Microchim. Acta, 2018, 185: 123. 4.Sun, Y., Liu, S., Qiao, Z., Shang, Z., Xia, Z.J., Niu, X.M., Qian, L.Q., Zhang, Y., Fan, L.Y., Cao, C.X.*, Xiao, H.*, Systematic comparison of exosomal proteomes from human saliva and serum for the detection of lung cancer, Anal. Chim. Acta 2017, 982:84-95. 5.He, Y.C., Kong, F.Z., Fan, L.Y., Wu, J.Y., Liu, X.P., Li, J., Sun, Y., Zhang, Q., Yang, Y., Wu, X.J., Xiao, H.*, Cao, C.X.*, Preparation of intact mitochondria using free-flow isoelectric focusing with post-pH gradient sample injection for morphological, functional and proteomics studies, Anal. Chim. Acta 2017, 982:200-208. 6.Xia, Z.J., Liu, Z., Kong, F.Z., Fan, L.Y., Xiao, H.*, Cao, C.X.*, Comparison of antimicrobial peptide purification via free-flow electrophoresis and gel filtration chromatography. Electrophoresis. 2017, 38(24):3147-3154. 7.Liu, Z., Xia, Z.J., Fan, L.Y., Xiao, H.*, Cao, C.X.*, An Ionic Coordination Hybrid Hydrogel for Bioseparation. Chem. Commun. 2017, 53, 5842-5845. 8.Zhang, Q., Fan, L.Y., Li, W.L., Cong, F.S., Zhong, R., Chen, J.J., He, Y.C., Xiao, H.*, Cao, C.X.*, A stable and convenient protein electrophoresis titration device with bubble removing system. Electrophoresis. 2017, 38(13-14):1706-1712. 9.Pratush, A., Zhang, Q., Cao, Y.R., Zhang, L.X., Li, G.Q., Liu X.P., Li, J., Jahan, S., Cong, F.S., Xiao, H.*, Fan, L.Y., Cao, C.X.*, A simple, openable and electroosmotic flow-free PMMA chip for electrophoretic titration of moving reaction boundary. Microchem. J. 2017, 132:20-27. 10.Jahan, S., Zhang, Q., Pratush, A., Xie, H.Y., Xiao, H.*, Fan, L.Y., Cao, C.X.*. In-Vial Temperature Gradient Headspace Single Drop Microextraction Designed by Multiphysics Simulation. Anal. Chem. 2016, 88:10490-10498. 11.Zhong, R., Xie, H.Y., Kong, F.Z., Zhang, Q., Jahan, S., Xiao, H.*, Fan, L.Y., Cao, C.X.*, Enzyme catalysis–electrophoresis titration for multiplex enzymatic assay via moving reaction boundary chip. Lab Chip, 2016, 16:3538-47. 12.Sun, Y., Xia, Z.J., Shang, Z., Sun, K.B., Niu, X.M., Qian, L.Q., Fan, L.Y., Cao, C.X.*, Xiao, H.*, Facile preparation of salivary extracellular vesicles for cancer proteomics. Sci. Rep. 2016, 6:24669. 13.Xiao, H.*, Zhang, Y., Kim, Y., Kim, S., Kim, J. J., Kim, K. M., Yoshizawa, J., Fan, L.-Y., Cao, C.-X., Wong, D.T.W.*, Differential proteomic analysis of human saliva using tandem mass tags quantification for gastric cancer detection. Sci. Rep. 2016, 6:22165. 14.Liu, Z., Fan, L.-Y., Xiao, H.*, Cao, C.-X.*, A multiple covalent crosslinked soft hydrogel for bioseparation. Chem. Commun. 2016, 52:3247-3250. 15.Xiao, H.*,†, Langerman, A.†, Zhang, Y., Khalid, O., Hu, S., Cheng-Xi Cao, Lingen, M.W., Wong, D.T.W.* Quantitative proteomic analysis of microdissected oral epithelium for cancer biomarker discovery. Oral Oncol. 2015, 51: 1011-1019. 16.Guo, C.G., Shang, Z., Yan, J., Li, S., Li, G.Q., Liu, R.Z., Qing, Y., Fan, L.Y., Xiao, H.*, and Cao, C.X.*. A tunable isoelectric focusing via moving reaction boundary for two-dimensional gel electrophoresis and proteomics. Talanta. 2015, 137:197-203. 17.Shen, Q.Y., Guo, C.G., Yan, J., Zhang, Q., Xie, H.Y., Jahan, S., Fan, L.Y., Xiao, H.*, and Cao, C.X.* Target Protein Separation and Preparation by Free-Flow flow Electrophoresis coupling with Charge-to-mass Ratio Analysis. J. Chromatogr. A. 2015, 1397:73-80. 18.Xiao, H.*, Zhang, L., Zhou, H., Lee, J.M., Garon, E.B., Wong, D.T.W.* Proteomic analysis of human saliva from lung cancer patients using two-dimensional difference gel electrophoresis and mass spectrometry. Mol. Cell. Proteomics 2012, 11:M111.012112. 19.Xiao, H.*, Wong, D.T.W.* Proteomic Analysis of Microvesicles in Human Saliva by GeLC-MS/MS. Anal. Chim. Acta 2012, 723, 61-67. 20.Xiao, H.*, Wong, D.T.W.* Method Development for Proteome Stabilization in Human Saliva. Anal. Chim. Acta 2012, 722, 63-69.

推荐链接
down
wechat
bug